Rchr
J-GLOBAL ID:200901062521011380   Update date: Feb. 01, 2024

Sugita Masahiko

スギタ マサヒコ | Sugita Masahiko
Research field  (3): Allergies and connective tissue disease ,  Immunology ,  Bacteriology
Research keywords  (10): ,  結核 ,  ワクチン ,  脂質 ,  生体防御 ,  cancer ,  tuberculosis ,  vaccine ,  lipid ,  Host defense
Research theme for competitive and other funds  (30):
  • 2021 - 2024 New vaccine strategies by the use of lipid immunity
  • 2020 - 2023 Identification of HLA class I molecules with the capacity of mediating lipopeptide presentation
  • 2019 - 2021 Basic mechanisms underlying lipopeptide antigen presentation
  • 2018 - 2021 Vaccine development against tuberculosis and AIDS by the use of lipid immunity
  • 2018 - 2020 Novel functions of human lipopeptide immunity in viral infection and autoimmunity
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Papers (96):
  • Daisuke Morita, Minori Asa, Masahiko Sugita. Engagement with the TCR induces plasticity in antigenic ligands bound to MHC class I and CD1 molecules. International immunology. 2023. 35. 1. 7-17
  • Tatsuaki Mizutani, Toshiaki Ano, Yuya Yoshioka, Satoshi Mizuta, Keiko Takemoto, Yuki Ouchi, Daisuke Morita, Satsuki Kitano, Hitoshi Miyachi, Tatsuaki Tsuruyama, et al. Neutrophil S100A9 supports M2 macrophage niche formation in granulomas. iScience. 2023. 106081-106081
  • Asa Minori, Morita Daisuke, Sugita Masahiko. T Cell activation and responses(human and Vitro)(Dynamic B-pocket remodeling is a basis for HLA class I molecules to bind peptides and lipopeptides). 日本免疫学会総会・学術集会記録. 2022. 51. Proceedings. WS26-O/P
  • Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita. Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding. Journal of Biological Chemistry. 2022. 298. 7. 102100-102100
  • Ei'ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, et al. TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation. Nature communications. 2021. 12. 1. 2299-2299
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MISC (67):
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Education (4):
  • - 1991 Kyoto University
  • - 1991 Kyoto University Graduate School, Division of Medical Science Internal Medicine
  • - 1984 Kyoto University Faculty of Medicine Department of Medical Science
  • - 1984 Kyoto University Faculty of Medicine Medicine
Work history (9):
  • 2001 - 2004 Nippon Medical School
  • 2001 - 2004 Professor, Nippon Medical School
  • 2004 - - 京都大学ウイルス研究所 教授
  • 2004 - - Professor, Institute for Virus Research,
  • 1999 - 2001 Harvard University
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Association Membership(s) (4):
日本内科学会 ,  日本免疫学会 ,  The Japanese Society of Internal Medicine ,  Japanese Society for Immunology
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