FURUSE MIKIO

フルセミキオ | FURUSE MIKIO

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.nips.ac.jp/dcs/

Research field (1)： Cell biology

Research keywords (5)：上皮極性 , tricellular junction , tight junction , cell adhesion , epithelial cells

Research theme for competitive and other funds (26)：

2021 - 2024 細胞間結合タイトジャンクションの形態形成メカニズムの解明
2020 - 2023 脳内環境を守るクモ膜バリアの分子基盤と生理的意義の解明に向けた萌芽的研究
2018 - 2021 Elucidation of the molecular mechanism of the paracellular barrier at triellular junctions
2016 - 2021 先端バイオイメージング支援プラットフォーム
2016 - 2019 Reconstitution of paracellular transport by establishment of a claudin-deficient epithelial cell line.

2015 - 2018 Dynamic mechanisms of regurating cell-cell junction and cell shape of epithelial cells unravelled by protein structure information

2014 - 2017 The molecular mechanism underlying the epithelial barrier formation by tricellular tight junctions

2013 - 2017 Roles of claudins in kidney water and electrolyte transport

2013 - 2017 Targeted disruption of a gene that encodes a signaling molecule for a neurite branching.

2005 - 2009 Molecular mechanisms of cell-cell adhesion in cancer cells

2006 - 2007 Identification and functional analyses of novel proteins involved in the regulation of epithelial cell-cell adhesion

2003 - 2004 Identification and characterication of novel proteins involved in epithelial morphogenesis

2002 - 2004 Claudins in the epithelium/endothelium barrier dysfucrition

2000 - 2004 Molecular mechanism for cell-cell adhesion in canceration and metastasis

2000 - 2004 Mechanism of the paracellular molecular transport

2001 - 2002 個体におけるタイトジャンクションの機能解析

2001 - 2002 Regulation of the tight junction barrier by synthetic peptides: Towards the development of a new drug delivery method

1999 - 2001 The claudin family : Its involvement in interecellular sealing and epithelial polarity

1999 - 2000 タイトジャンクションの膜タンパク質クローディンの機能解析

1999 - 2000 CLAUDINS AND OCCLUDIN : COMPARISON WITH CONNEXIN

1998 - 1999 Development of a new drug delivery method by the use of occludin molecules

1997 - 1999 タイトジャンクションの構成分子オクルディンの高次構造と結合タンパク質の研究

1998 - 1998 βカテニンの分解によるシグナル伝達機構

1997 - 1998 Structure and function of occludin in tight junctions : comparison with connexin gap junctions

1996 - 1998 The structure and functions of occludin

1996 - 1996 オクルディンの機能阻害によるタイトジャンクション機能の解析

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Papers (149)：

Thanh Phuong Nguyen, Tetsuhisa Otani, Motosuke Tsutsumi, Sachiko Fujiwara, Tomomi Nemoto, Toshihiko Fujimori, Mikio Furuse. Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex. 2023
Shintaro Miyazaki, Tetsuhisa Otani, Kei Sugihara, Toshihiko Fujimori, Mikio Furuse, Takashi Miura. Mechanism of interdigitation formation at apical boundary of MDCK cell. iScience. 2023. 106594-106594
Tomohito Higashi, Akira C Saito, Yugo Fukazawa, Mikio Furuse, Atsuko Y Higashi, Masahiro Ono, Hideki Chiba. EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. The Journal of cell biology. 2023. 222. 1
Mikio Furuse, Daiki Nakatsu, Wendy Hempstock, Shiori Sugioka, Noriko Ishizuka, Kyoko Furuse, Taichi Sugawara, Yugo Fukazawa, Hisayoshi Hayashi. Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells. Cell structure and function. 2022
Sima Jonusaite, Nathalie Oulhen, Yasushi Izumi, Mikio Furuse, Takashi Yamamoto, Naoaki Sakamoto, Gary Wessel, Andreas Heyland. Identification of the genes encoding candidate septate junction components expressed during early development of the sea urchin, Strongylocentrotus purpuratus, and evidence of a role for Mesh in the formation of the gut barrier. Developmental Biology. 2022

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MISC (144)：

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Professional career (1)：

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