2019 - 2021 High-throughput verification of pathways regulating kidney diseases
2017 - 2020 Active control of 3D arrangement on mesoscopic particles and their application to biological imaging
2016 - 2020 Neurons network analysis with a bull's eye-pattern plasmonic chip
2016 - 2019 Application of hybrid nano-assembly for in-vitro synthetic biology tool
2016 - 2018 Synthesis of organic nanocrystals with the function of molecular recognition via material-binding proteins
2013 - 2017 Study of sensitive immunosensor with the ZnO-coated plasmonic chip
2013 - 2016 Challenge to the development of small tetraspecific and tetravalent antibody as innovative cancer therapeutic antibodies
2013 - 2016 Bio-MEMS with reversible antibody on sensor chip
2010 - 2016 Comprehensive Research on Fusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control
2012 - 2016 Bio-design for interface molecules in nano scale
2012 - 2014 nanomanipulationof antibody based on liquid-binding peptide
2011 - 2012 DNAグロビュール構造を核とした多元積層ナノクラスターの構築
2011 - 2012 Promotion of the 4Rs in animal experiments by the development of a production process for polyclonal antibodies using a goldfish
2010 - 2012 Study of sensitive biosensor chip including periodic structure coated with silver and zinc oxide
2010 - 2012 ナノ世界のインターフェイス構築へのタンパク質工学的デザイン学
2008 - 2012 Synthesis of organic-inorganic hybrid nanoparticles by supercritical fluid and thermodynamics and unit operation of hybrid nanoparticles
2009 - 2011 Dynamic nanocrystal clusters on compacted DNA structure by means of biomineralization
2008 - 2009 EGFR陽性がんの標的治療を目指す低分子抗体の創製
2008 - 2008 有機無機ハイブリッドナノ粒子の超臨界水熱反応工学の確立
2007 - 2008 磁気マリモ・リング構造の創製と磁場中ダイナミクス
2006 - 2008 Peptide and protein engineering for spontaneous assembly of ceramic nanocrystals
2006 - 2008 Bioassisted Room-Temperature Synthesis and Structural Control of Advanced Nanomaterials
2004 - 2008 Protein Engineering for Construction of Bio-interfaces
2007 - 2007 金材料特異的抗体から発想される革新的ワンポット蛋白質ネットワークアッセイ
2006 - 2007 左手系ナノハイブリッド材料の創生に向けて
2005 - 2007 Development of a novel system for solubilization and preparation of proteins based on the aggregation suppression effects of arginine on proteins
2005 - 2007 Supercritical synthesis of organic-monolayer modified nanocrystals and organic-inorganic hybrid nanomaterials
2006 - 2006 高分解動態イメージングを可能にする超臨界ハイブリッドナノ結晶プローブの創生
2004 - 2005 蛋白質活性再生における添加剤効果の解明と汎用的蛋白質調製系の構築
2004 - 2004 生体分子表面修飾によるナノ粒子の多様で動的な構造形成
2002 - 2004 Elucidation of chemical synthesis from sugar and solvent effect on the reaction using supercritical microreactor
2000 - 2003 Application of multi-dimensional NMR to biomolecules and proteins
2003 - 2003 超臨界水中での有機無機複合ナノ粒子合成
2002 - 2003 蛋白質の大量発現で形成される封入体の固体核磁気共鳴法による構造解析
2001 - 2003 GENERATION AND UTILIZATION OF NOVEL HUMAN ANTIBODY MOLECULES BASED ON GENETIC INFORMATION
2001 - 2003 Recovery of chemicals from sugar in supercritical fluids for oligochemistry cycle
2002 - 2002 ホメオスタシス社会システムの構築とそのための化学工学の新学理
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Papers (232):
Wijak Yospanya, Akari Matsumura, Yukihiro Imasato, Tomoyuki Itou, Yusuke Aoki, Hikaru Nakazawa, Takashi Matsui, Takeshi Yokoyama, Mihoko Ui, Mitsuo Umetsu, et al. Design of Cyborg Proteins by Loop Region Replacement with Oligo(ethylene glycol): Exploring Suitable Mutations for Cyborg Protein Construction Using Machine Learning. Bulletin of the Chemical Society of Japan. 2024
Andrejs Tučs, Tomoyuki Ito, Yoichi Kurumida, Sakiya Kawada, Hikaru Nakazawa, Yutaka Saito, Mitsuo Umetsu, Koji Tsuda. Extensive antibody search with whole spectrum black-box optimization. Scientific Reports. 2024. 14. 1
Yutaka Tamaru, Shuji Nakanishi, Kenya Tanaka, Mitsuo Umetsu, Hikaru Nakazawa, Aruto Sugiyama, Tomoyuki Ito, Naofumi Shimokawa, Masahiro Takagi. Recent research advances on non-linear phenomena in various biosystems. Journal of Bioscience and Bioengineering. 2023. 136. 2. 75-86
Hikaru Nakazawa, Taiji Katsuki, Takashi Matsui, Atsushi Tsugita, Takeshi Yokoyama, Tomoyuki Ito, Sakiya Kawada, Yoshikazu Tanaka, Mitsuo Umetsu. Synthesis of epitope-targeting nanobody based on native protein-protein interactions for FtsZ filamentation suppressor. Biotechnology journal. 2023. e2300039
Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu. Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning. mAbs. 2023. 15. 1. 2168470-2168470