Kataoka Naoyuki

カタオカナオユキ | Kataoka Naoyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.vm.a.u-tokyo.ac.jp/seika/

Research field (1)： Molecular biology

Research keywords (7)： Epigenetics , Signal Transduction , 遺伝子発現調節 , RNA病 , 転写後調節 , RNA輸送 , RNAスプライシング

Research theme for competitive and other funds (22)：

2024 - 2027 Immunopathology of visceral leishmaniasis
2023 - 2026 Elucidation of post-transcriptional regulation mechanism regulated by amino-acid metabolic signal
2023 - 2026 Regulation of insulin-like activities using signaling complexes formed by RNA and IRS-1.
2022 - 2025 生体の糖脂質代謝スイッチを誘導するオルニチン情報伝達経路の同定とその制御
2022 - 2024 Establishment of a novel Developmental RNA Biology field under hypoxia by using dual fluorescent color based splicing reporters

2021 - 2024 Immunopathology of visceral leishmaniasis

2021 - 2022 代謝性アミノ酸シグナルによる疾患治療法開発に向けた基礎研究

2021 - 2022 代謝制御性アミノ酸シグナルによる転写後調節機構の解明

2021 - 2022 A novel approach to taget aberrant epigenetic regulation caused by misregulation of RNA splicing with mutated splicing factors

2018 - 2021 Elucidation of a novel mechanism for regulation of signal transduction through Insulin receptor alternative splicing

2015 - 2018 Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significance

2013 - 2018 Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex

2014 - 2016 Elucidation of the molecular mechanisms of STAT3-alternative splicing and the physiological functions of STAT3-splicing isoforms

2013 - 2015 Identification and elucidation of the roles of RNAs associated with insulin receptor substrate

2012 - 2015 Identification of a small molecule that induces autophagy-mediated degradation of TAU

2011 - 2013 スプライシング異常に起因する「RNA病」の解明と治療

2010 - 2012 Analysis of abnormal splicing mechanism and application for thetreatment of Muscular Dystrophy

2009 - 2011 選択的スプライシングを介したシナプス形成調節機構の解明

2007 - 2008 転写と共役したDNA修復とmRNAスプライシングとの連携の解析

2004 - 2007 Analysis of mRNA localization mechanism in neuronal cells mediated by splicing-dependent complex, EJC

2005 - 2006 核内におけるイントロン分解とスプライシング因子のリサイクル機構の解明

2003 - 2004 核内におけるイントロン分解とスプライシング因子のリサイクル機構の解明

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Papers (82)：

Miki Kise, So Masaki, Naoyuki Kataoka, Kenji Suzuki. RNA binding protein CUGBP2/ETR-3 regulates STAT3 alternative splicing. Biochemical and biophysical research communications. 2024. 739. 151000-151000
Miki Kise, So Masaki, Naoyuki Kataoka, Kenji Suzuki. Identification of Entinostat as a Novel Modifier of STAT3 Pre-mRNA Alternative Splicing. Biological & pharmaceutical bulletin. 2024. 47. 9. 1504-1510
Naoyuki Kataoka. The Nuclear Cap-Binding Complex, a multitasking binding partner of RNA polymerase II transcripts. Journal of biochemistry. 2023. 175. 1. 9-15
Haruka Furuta, Yina Sheng, Ayaka Takahashi, Raku Nagano, Naoyuki Kataoka, Claire Marie Perks, Rachel Barker, Fumihiko Hakuno, Shin-Ichiro Takahashi. The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3. International journal of molecular sciences. 2023. 24. 20
Satoru Shinriki, Mayumi Hirayama, Akiko Nagamachi, Akihiko Yokoyama, Takeshi Kawamura, Akinori Kanai, Hidehiko Kawai, Junichi Iwakiri, Rin Liu, Manabu Maeshiro, et al. DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells. Leukemia. 2022. 36. 11. 2605-2620

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MISC (113)：

正木聡, 片岡直行. Development of cure for sarcopenia focusing on glycolytic enzymes. 三井住友海上福祉財団研究結果報告書集. 2024. 28
片岡直行. 代謝性アミノ酸シグナルによる疾患治療法開発に向けた基礎研究. 医科学応用研究財団研究報告(CD-ROM). 2024. 41
松本英里, 千葉友希, 田中智, 片岡直行. Analysis of the mechanism of Myelodysplastic Syndromes (MDS) caused by ZRSR2 mutation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
正木聡, 土田真緒, 西山菜摘, 末永朝美, 片岡直行, 鈴木健二. Elucidation of the physiological significance of PKM splicing focusing on oxidative stress responses. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
正木聡, 土田真緒, 末永朝美, 西山菜摘, 片岡直行, 鈴木健二. Elucidation of molecular functions of PKM splicing isoforms in myogenic differentiation. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (1)：

遺伝性疾患の予防・改善剤

Education (3)：

1991 - 1995 Kyoto University
1989 - 1991 Kyoto University Graduate School of Science
1984 - 1989 Kyoto University

Professional career (1)：

Ph.D. (Kyoto University)

Work history (6)：

2019/07 - 現在 The University of Tokyo
2016/04 - 2019/06 The University of Tokyo
2011/10 - 2016/03 Kyoto University
2011/04 - 2011/09 Kyoto University
2007/03 - 2011/03 Tokyo Medical and Dental University Medical Research Institute

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Committee career (2)：

2016/04 - 2018/03 日本RNA学会評議員
2014/04 - 2016/03 日本RNA学会評議員

Awards (2)：

2011/03 - 東京医科歯科大学・難治疾患研究所平成22年度若手研究者研究発表会第一位
2009/03 - 東京医科歯科大学・難治疾患研究所平成20年度若手研究者研究発表会第一位

Association Membership(s) (4)：

The RNA Society , THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE RNA SOCIETY OF JAPAN

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