Sawa Hitoshi

サワヒトシ | Sawa Hitoshi

Affiliation and department：
Job title：教授
Other affiliations (1)：

総合研究大学院大学教授

Homepage URL (1)： http://square.umin.ac.jp/Nemalab/Home.html

Research field (3)： Molecular biology , Cell biology , Developmental biology

Research keywords (24)： C.elegans , Frizzled , 微小管 , Hox , 紡錘体 , 線虫 , TCF , 非対称細胞分裂 , βcatenin , cell diversity , cell differentiation , transcription , imaging , chromatin , cell fate , cell polarity , stem cell , epigenetics , Wnt , 発生 , 非対称分裂 , Development , astmmetic celldivision , Celegans

Research theme for competitive and other funds (12)：

2021 - 2025 Coordination of Cell polarity by Hox genes and graded expression of Wnt receptors
2016 - 2022 Coordinated cell polarization mediated by Wnts
2016 - 2019 Mechanism for mirro-symmetric organogenesis
2015 - 2016 Visualization of DNA binding proteins bound to specific loci in vivo
2010 - 2016 Management of the research group on logic for biological pattern formation

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Papers (47)：

Takefumi Negishi, Saho Kitagawa, Natsumi Horii, Yuka Tanaka, Nami Haruta, Asako Sugimoto, Hitoshi Sawa, Ken-Ichiro Hayashi, Masahiko Harata, Masato T Kanemaki. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans. Genetics. 2021. 220. 2
Takefumi Negishi, Masayo Asakawa, Masato Kanemaki, Hitoshi Sawa. Modified auxin improves the auxin-inducible degradation (AID) system for laid C. elegans embryos. microPublication. Biology. 2019. 2019
Kenji Sugioka, Lars-Eric Fielmich, Kota Mizumoto, Bruce Bowerman, Sander Van Den Heuvel, Akatsuki Kimura, Hitoshi Sawa. Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division. Proceedings of the National Academy of Sciences of the United States of America. 2018. 115. 5. E954-E963
Shinji Ihara, Sohei Nakayama, Yoshiko Murakami, Emiko Suzuki, Masayo Asakawa, Taroh Kinoshita, Hitoshi Sawa. PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis. JOURNAL OF CELL SCIENCE. 2017. 130. 3. 602-613
Arata Y, Hiroshima M, Pack CG, Ramanujam R, Motegi F, Nakazato K, Shindo Y, Wiseman PW, Sawa H, Kobayashi TJ, et al. Cortical Polarity of the RING Protein PAR-2 Is Maintained by Exchange Rate Kinetics at the Cortical-Cytoplasmic Boundary. Cell reports. 2016. 17. 1. 316-316

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MISC (28)：

伊原伸治, 中山創平, 村上良子, 鈴木えみ子, 浅川昌代, 大石あかね, 木下タロウ, 澤斉. PIGNは小胞体のATP量を維持する事で、タンパク質の分泌を制御している. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4T17p-07(3P0364)]
伊原伸治, 中山創平, 吉田直樹, 澤斉. 線虫における基底膜動態の維持に関わる糖脂質GPIの役割. 日本細胞生物学会大会講演要旨集. 2014. 66回. 112-112
Sawa H, Korswagen HC. Wnt signaling in C. elegans. WormBook : the online review of C. elegans biology. 2013. 1-30
Kenji Sugioka, Hitoshi Sawa. Formation and functions of asymmetric microtubule organization in polarized cells. CURRENT OPINION IN CELL BIOLOGY. 2012. 24. 4. 517-525
Hitoshi Sawa. Control of Cell Polarity and Asymmetric Division in C. elegans. PLANAR CELL POLARITY DURING DEVELOPMENT. 2012. 101. 55-76

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Lectures and oral presentations (13)：

Regulation of cell polarity and asymmetric division by Wnts in C. elegans
(56th Annual Meeting of the Japanese Society of Developmental Biologists 2023)
Wnts may control cell polarity independent of Wntless and CRD of the receptors
(2022)
Regulation of cell polarity and asymmetric division by Wnts in C. elegans
(The 68th NIBB Conference "Principles of Cell Communication in the Tissue" 2022)
細胞極性化におけるWntと受容体局在の相互制御
(第43回日本分子生物学会年会 2020)
細胞多様性を産み出す基本的原理を探して
(虫の夕べ 2020)

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Education (3)：

1986 - 1991 Kyoto University
1982 - 1986 Kyoto University Faculty of Science
Kyoto University

Professional career (1)：

Ph. D.

Work history (6)：

2011/10 - 現在 National Institute of Genetics
2001/04 - 2011/09 理化学研究所 CDB チームリーダー
1998/10 - 2001/09 Osaka University Faculty of Medicine
1997/04 - 1998/09 Osaka University Faculty of Medicine
1994 - 1997 MIT Biology

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Committee career (5)：

2012/01 - 現在日本発生生物学会運営委員
2011/10 - 現在 F1000 Faculty
2011/01 - 現在 Caenorhabditis Genetics Center Advisory Board
2011 - 現在 Developmental Dynamics Editorial Board
2002/09 - 現在ナショナルバイオリソースプロジェクト「実験動物線虫」運営委員

Association Membership(s) (5)：

JAPAN SOCIETY FOR CELL BIOLOGY , 日本分子生物学会 , 日本発生生物学会 , The Molecular Biology Society of Japan , The Japanese Society of Developmental Biologist

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