Akimoto Yoshihiro

アキモトヨシヒロ | Akimoto Yoshihiro

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.kyorin-u.ac.jp/univ/user/medicine/anat2/

Research field (1)： Anatomy

Research keywords (4)：糖鎖生物学 , 糖尿病 , 免疫組織細胞化学 , Immunohisto- & cytochemistry

Research theme for competitive and other funds (28)：

2022 - 2025 Elucidation of the localization and the role of O-GlcNAc-modified actin and phosphorylated actin in the nucleus
2018 - 2021 Study on the role of nuclear glycosylated actin in the diabetic complications
2016 - 2019 Mechanism of mucosal immunity activation by exosome
2016 - 2019 The functional analysis of glycocalyx on the vascular permeability
2015 - 2018 Studies on the efficacy of toxin neutralization and safety of Shiga toxin-specific secretory IgA type plantibody produced by practical plants

2015 - 2018 Integration of proteomics and metabolomics for drug discovery based on a search for the pathophysiology in glomerulosclerosis

2015 - 2017 プラズマ照射による組織細胞への分子レベルでの影響の超微形態学的解析

2013 - 2017 Analysis of the construction of extracellular environment and regulation of morphogenesis by extracellular arylsulfatase

2013 - 2016 Vulnerable effect of anesthetics on developing brain and vascular permeability

2013 - 2015 プラズマ照射による細胞、組織への影響の分子形態学的解析

2012 - 2015 Analysis on changes in the molecular structure of glomerulus accompanying with diabetic nephropathy

2010 - 2012 Analysis of the tissue-specific molecular structure and the regulatory mechanism in morphogenesis by extracellular arylsulfatase

2010 - 2012 Role of Ubiquitin specific protease 40 in Glomerulus

2009 - 2011 Functional analysis of glucocorticoid induced transcript 1(GLCCI1)

2008 - 2010 Analysis of the changes in the molecular structure of basement membrane accompanying by the diabetic keratopathy

2006 - 2007 Role of System LAmino Acid Transporter in Podocyte Cell Biology

2004 - 2005 Change in the molecular structure of extracellular matrix accompanied by diabetic keratopathy : Immunohistochemical study

1998 - 2000 O-グリコシド結合型N-アセチルグルコサミン転移酵素の組織、細胞における発現

1995 - 1995 皮膚分化過程にある細胞外マトリックスとインテグリンの発現......組織細胞化学的研究

1994 - 1994 表皮基底膜形成過程における内在性β-ガラクトシド結合性レクチンの発現

1993 - 1993 表皮基底膜形成過程における表皮と基底膜との接着機構に関する免疫組織化学的研究

1992 - 1992 表皮基底膜形成過程における表皮と基底膜との接着機構に関する免疫組織化学的研究

1991 - 1991 表皮基底膜の形成過程に関する免疫組織細胞化学的研究

1990 - 1990 表皮基底膜の形成過程に関する電顕細胞化学的研究

皮膚の発生における Homeobox 遺伝子の機能解析

O-GlcNAc転移酵素の糖尿病における役割

細胞外マトリックスに関する免疫組織細胞化学的研究

Immunohisto- & cytochemical study on extracellular matrix

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Papers (157)：

寺本直弥, 前澤善朗, 山口彩乃, 金子ひより, 南塚拓也, 加藤尚也, 井出真太郎, 井出佳奈, 北本匠, 越坂理也, et al. 腎症(4) 糖尿病性腎臓病のポドサイトにおける転写因子Tcf21の機能解析. 糖尿病合併症. 2023. 37. Suppl.1. 171-171
安藤直朗, 鵜澤康二, 吉川貴紘, 中澤春政, 森山潔, 秋元義弘, 萬知子, 牛山明. 出血性ショック時の血管内皮細胞障害に対するHES130早期投与の効果. Shock: 日本Shock学会雑誌. 2023. 37. 1. 84-84
Tadao Ando, Kohji Uzawa, Takahiro Yoshikawa, Shingo Mitsuda, Yoshihiro Akimoto, Tomoko Yorozu, Akira Ushiyama. The effect of tetrastarch on the endothelial glycocalyx layer in early hemorrhagic shock using fluorescence intravital microscopy: a mouse model. Journal of Anesthesia. 2023. 37. 1. 104-118
Jean Cacheux, Aurélien Bancaud, Daniel Alcaide, Jun-ichi Suehiro, Yoshihiro Akimoto, Hiroyuki Sakurai, Yukiko T. Matsunaga. Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport. 2023
Rie Nishida, Dai Suzuki, Yoshihiro Akimoto, Sachie Matsubara, Junri Hayakawa, Akira Ushiyama, Kiyohito Sasa, Yoichi Miyamoto, Takehiko Iijima, Ryutaro Kamijo. Exploring the pathophysiological mechanism of interstitial edema focusing on the role of macrophages and their interaction with the glycocalyx. Journal of oral biosciences. 2023. 65. 1. 111-118

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MISC (93)：

前澤善朗, 寺本直弥, 塚越彩乃, 南塚拓也, 加藤尚也, 金子ひより, 越坂理也, 遠藤裕介, 秋元義弘, 横手幸太郎. 糖尿病性腎臓病のポドサイトにおける転写因子Tcf21の役割. 糖尿病. 2022. 65. Suppl.1. S-149
寺本直弥, 前澤善朗, 遠藤裕介, 秋元義弘, 横手幸太郎. 糖尿病性腎臓病における転写因子Tcf21の機能解析. 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web). 2021. 53rd
UCHIDA Aya, SUZUKI Honoka, TAKASE Hinako M, HIRATE Yoshikazu, HIRAMATSU Ryuji, KUDO Akihiko, AKIMOTO Yoshihiro, KANAI Masami, KANAI Yoshiakira. Mouse rete testis regulates the formation of Sertoli valve epithelia and subsequent spermatogenesis. The Journal of Reproduction and Development Supplement. 2021. 114. OR-40-OR-40
Ikehara Sanae, Akimoto Yoshihiro, Yamaguchi Takashi, Sakakita Hajime, Hori Masaru, Ikehara Yuzuru. Understanding and application of the biological function of the glycosylation by through the low-temperature atmospheric pressure plasma technology. JSAP Annual Meetings Extended Abstracts. 2020. 2020.2. 101-101
三浦ゆり, 早川敦子, 早川敦子, 津元裕樹, 梅澤啓太郎, 川上恭司郎, 福井浩二, 秋元義弘, 遠藤玉夫. Mechanisms of renal diabetic fibrosis in Goto-Kakizaki rats. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)

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Books (19)：

Plasma Medical Science
Academic Press 2018
Essentials of Glycobiology. 3rd ed.
Cold Spring Harbor Laboratory Press 2017
Handbook of glycoconjugate application
2015
Glycoscience: Biology and Medicine.
Springer 2015
Pre-embedding electron microscopy methods for glycan localization in chemically fixed mammalian tissue using horseradish peroxidase-conjugated lectin. In: ImmunoelectronMicroscopy. (Schwartzbach SD,Osafune T eds.)
Humana Press 2010 ISBN:9781607617822

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Professional career (2)：

(BLANK) (Kyorin University)
(BLANK) (The University of Tokyo)

Work history (7)：

2014 - 現在 Kyorin University Faculty of Medicine
2007 - 2014 Kyorin University Faculty of Medicine
1998 - 2007 Kyorin University Faculty of Medicine
1997 - 1998 Kyorin University Faculty of Medicine
1995 - 1997 米国アラバマ大学医学部

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Committee career (8)：

2021/06 - 現在日本顕微鏡学会常務理事
2020/01 - 現在日本組織細胞化学会理事
2017/05 - 現在日本臨床分子形態学会評議員
2005/05 - 現在日本顕微鏡学会代議員
2002/01 - 現在日本組織細胞化学会評議員

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Awards (2)：

2006/08 - 日本組織細胞化学会論文賞
1999/01 - 風戸研究奨励賞

Association Membership(s) (5)：

THE JAPANESE SOCIETY FOR CLINICAL MOLECULAR MORPHOLOGY , 杏林医学会 , 日本組織細胞化学会 , THE JAPANESE SOCIETY OF MICROSCOPY , 日本解剖学会

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