Oike Masahiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmacology

Research keywords (10)： in silico drug development , 上皮間葉変換 , 機械刺激感知機構 , カルシウム , 血管内皮 , 血管平滑筋 , mechanosensitivity , calcium , vascular endothelium , vascuar smooth muscle

Research theme for competitive and other funds (15)：

2013 - 2015 In silico screening of small molecule compounds for substitution of neutralizing antibodies.
2007 - 2008 Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production
2006 - 2007 内皮由来血管組織化因子の同定
2006 - 2007 Mechanosensory molecules and mechanical stress-induced primary responses in vascular endothelial cells.
2005 - 2006 Pharmacological study on the mechano-sensitive molecules involved in vascular smooth muscle and endothelial cells.

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Papers (32)：

Chiwaka Kimura, Shuhei Konishi, Maki Hasegawa, Masahiro Oike. Development of vascular smooth muscle contractility by endothelium-derived transforming growth factor beta proteins. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2014. 466. 2. 369-380
Kimura C, Hayashi M, Mizuno Y, Oike M. Endothelium-dependent epithelial-mesenchymal transition of tumor cells: Exclusive roles of transforming growth factor β1 and β2. Biochimica et biophysica acta. 2013. 1830. 10. 4470-4481
Chiwaka Kimura, Masayuki Hayashi, Yuri Mizuno, Masahiro Oike. Endothelium-dependent epithelial-mesenchymal transition of tumor cells: Exclusive roles of transforming growth factor beta(1) and beta(2). BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2013. 1830. 10. 4470-4481
Yuko Matsunaga, Satoru Fukuyama, Toshiaki Okuno, Fumiyuki Sasaki, Takehiko Matsunobu, Yukari Asai, Koichiro Matsumoto, Kazuko Saeki, Masahiro Oike, Yukari Sadamura, et al. Leukotriene B-4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB JOURNAL. 2013. 27. 8. 3306-3314
Yuko Matsunaga, Satoru Fukuyama, Toshiaki Okuno, Fumiyuki Sasaki, Takehiko Matsunobu, Yukari Asai, Koichiro Matsumoto, Kazuko Saeki, Masahiro Oike, Yukari Sadamura, et al. Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB Journal. 2013. 27. 8. 3306-3314

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MISC (63)：

大池正宏. コンピューターシミュレーションによる動物実習の代替. 2014
Masahiro Oike, Maki Hasegawa, Chiwaka Kimura. Maintenance of the contractility of vascular smooth muscle by endothelium-derived proteins. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 202P-202P
Masahiro Oike, Chiwaka Kimura. Organization of vascular smooth muscle cells by endothelium-derived protein. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 157P-157P
Masahiro Oike, Chiwaka Kimura. Transforming growth factor beta(1)-induced epithelial-mesenchymal transition alters calcium mobilizing properties and endogenous ATP release in A549 cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 220P-220P
Masayuki Hayashi, Masahiro Oike. Activation and release of TGF beta(1) from confluent endothelial cells by intercellular communications. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 79P-79P

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Books (3)：

ベッドサイドの薬理学
丸善出版 2018
Annual Review 2006 呼吸器「気道平滑筋の生物学」
中外医学社 2006
Histamine Research in the New Millenium. "Glucose overload attenuates histamine H2 receptor-mediated Ca2+ mobilization due to protein kinase C production in bovine cerebral endothelial cells."
Elsevier 2001

Lectures and oral presentations (4)：

国産無償創薬ソフトを使った臨床からの新薬再開発の提案
(第55回日本生物物理学会 2017)
myPrestoを用いた医学生へのインシリコ創薬教育とその意義
(第90回日本薬理学会年会 2017)
インシリコ手法による新規機序の低分子TGFβ1阻害薬開発の試み
(第89回日本薬理学会年会 2016)
SARS-CoV-2スパイク蛋白の受容体結合部位と結合する人工抗体の開発
(第95回日本薬理学会年会 2022)

Works (1)：

血管内皮細胞の機械的刺激感受性に及ぼす重力の影響に関する研究
1996 - 2002

Professional career (1)：

Ph.D.

Committee career (1)：

日本薬理学会学術評議員

Association Membership(s) (2)：

THE CHEM-BIO INFORMATICS SOCIETY , 日本薬理学会

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