Matsumoto Gen

マツモトゲン | Matsumoto Gen

Affiliation and department：
Job title： Associate Professor

Research field (3)： Neuropathology , Molecular biology , Neuroanatomy and physiology

Research keywords (8)： autophagy receptor , selective autophagy , neurodegenerative disease , 包括脳ネットワーク , リン酸化 , p62 , ライブセルイメージング , アグリソーム

Research theme for competitive and other funds (22)：

2022 - 2027 Molecular mechanism for aggrephagy induction
2022 - 2025 Elucidation of alpha-synuclein aggregation inhibition mechanism by lysophospholipids and development of drug discovery for neurodegenerative diseases
2024 - 2025 タンパク質凝集体分解促進剤(ADI)による神経変性疾患治療薬の開発
2022 - 2024 Novel aggrephagy pathway for Tau amyloid degradation
2022 - 2024 アグリファジー誘導化合物の標的分子探索とタウオパチー治療薬開発

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Papers (43)：

Rin Yanai, Tomoki T Mitani, Etsuo A Susaki, Takeharu Minamihisamatsu, Masafumi Shimojo, Yuri Saito, Hiroshi Mizuma, Nobuhiro Nitta, Daita Kaneda, Yoshio Hashizume, et al. A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology. Brain Communications. 2024. 6. 5
Shigeo Sakuragi, Tomoya Uchida, Naoki Kato, Boxiao Zhao, Akito Hattori, Yoshihiro Sakata, Yoshiyuki Soeda, Akihiko Takashima, Hideaki Yoshimura, Gen Matsumoto, et al. Inducing aggresome and insoluble tau aggregation using an optogenetic tool. 2024
Taku Hatano, Ayami Okuzumi, Gen Matsumoto, Tsunemi Taiji, Nobutaka Hattori. α-Synuclein: A Promising Biomarker for Parkinson's Disease and Related Disorders. Journal of movement disorders. 2024
Hiroko Bannai, Akihiko Takashima, Yoshiyuki Soeda, Hideaki Yoshimura, Gen Matsumoto, Naruhiko Sahara, Michio Hiroshima, Mitsuru Hattori, Takeharu Nagai. Research on the molecular mechanism of singularity phenomenon in neurological disorders. Biophysics and Physicobiology. 2024
奥住文美, 波田野琢, 松本弦, 服部信孝. α-シヌクレインシードの伝播凝集メカニズム. 神経治療学. 2023. 40. 6. S254-S254

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MISC (25)：

Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-Ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, et al. Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nature medicine. 2023. 29. 6. 1448-1455
奥住文美, 波田野琢, 松本弦, 服部信孝, 服部信孝. α-シヌクレインシードの伝播凝集メカニズム. 神経治療学(Web). 2023. 40. 6
村井清人, 佐伯和信, 遠藤大輔, 遠藤大輔, 高村敬子, 高村敬子, 松本弦, 田口紘平, 弦本敏行, 弦本敏行. 組織中における管腔走行の可視化を目的とした組織透明化法の検討. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
Cellar model of Tau fibrils and dementia study. Cosmo Bio News. 2020. 168. 1-3
松本弦, 森望. 超解像蛍光顕微鏡でみるアグリファジーと凝集化タウ. Dementia Japan. 2018. 32. 1. 2-11

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Patents (3)：

Books (2)：

Lectures and oral presentations (19)：

Enhanced intracellular degradation of Tau fibrils by aggrephagy induction
(2021)
Development of fibrillar tau cell line and tau aggregation suppressor compounds
(The 64th Annual Meeting of the Japanese Society for Neurochemistry 2021)
Aggrephagic degradation of intracellular fibrillar Tau
(2020)
超解像顕微鏡による細胞内タンパク質凝集体の形態解析
(第62回日本顕微鏡学会九州支部会・学術講演会 2020)
p62/SQSTM1リン酸化促進剤による新規オートファジー制御機構
(新学術領域研究「マルチモードオートファジー」第2回班会議 2020)

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Education (1)：

Professional career (1)：

Work history (9)：

2024/04 - 現在 Osaka Metropolitan University Graduate School of Medcine Department of Basic Medical Science
2023/04 - 現在 National Institutes for Quantum and Radiological Science and Technology
2021/07 - 現在 Juntendo University
2014/09 - 2024/03 Nagasaki University Graduate School of Biomedical Sciences
2013/04 - 2015/03 Juntendo University Graduate School of Medicine

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Committee career (1)：

Association Membership(s) (4)：

日本解剖学会 , 日本神経科学会 , 日本分子生物学会 , 日本細胞生物学会

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