Research field (1)：
Healthcare management, medical sociology
Research theme for competitive and other funds (30)：
2021 - 2024 The Web System and Prognostic Model for Mental Support of Critically Ill Patients and Families
2020 - 2023 Construction and implementation research of PRO and feedback system to clarify QOL value after surgery
2018 - 2021 Renewal of severely damaged livers by activating hepatic progenitor cells
2017 - 2020 Translational research for clinical apply using liver stem cells from cell banking
2016 - 2020 Analysis of Intestinal disorder and liver damage resulting from cardiac arrest
2014 - 2017 Translational research of the regenerative treatment of using human hepatic stem cells which were frozen by super-freezing program
2014 - 2017 肝切除術後肝不全予防のための術中ビジリオモニタリングによる新規管理法の開発
2014 - 2016 Research for the establishment of human hepatocytic progenitor cells
2013 - 2016 Fundamental Researches for the Application of Human Small Hepatocytes in Clinical Treatment
2012 - 2015 Developing a novel vaccine therapy targeting cancer stem cells
2012 - 2015 Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids
2011 - 2013 A clinical and basic research for developing human small hepatocyte bank using super-cooling program and generating mass hybrid mouse.
2010 - 2012 Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.
2009 - 2011 Analysis on factors relating metastasis in human gastric cancer cell line focusing on the metastasis patterns
2009 - 2011 Basic research for the production of human hepatocytes and the transplantation of hepatic tissues
2008 - 2010 Development of hybrit mouse with humanized liver using superfreezing preserved human small hepatocytes.
2008 - 2009 免疫逃避克服による新規癌ペプチドワクチン療法の確立
2007 - 2009 Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver
2007 - 2008 The analysis of the gene cluster and biological function about the gastric cancer cell lines highly metastatic to liver and lymph node metastasis
2007 - 2008 Analysis of the hepatic transporter expression and the research regarding the control in the large animal hepatectomy model
2006 - 2007 Development of novel cocktail solutions for cryo-preserving human small hepatocytes and generation of humanoid mouse liver
2006 - 2007 高い有効性を誘導するための新たなる癌ペプチドワクチン療法適応決定因子の確立
2005 - 2007 Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids
2005 - 2006 Development of new therapy for prevention of fibrosis in liver cirrhosis or chronic pancreatitis.
2003 - 2005 Research of the mechanism of non-obstructive cholestasis in severe infection and of the treatment for hepatic insufficiency
2003 - 2004 活性型小型肝細胞と骨髄細胞とによる全肝再生置換細胞移植方法の確立
2002 - 2004 Identification of specific surface proteins in small hepatocytes and reconstruction of hepatic organoids ex vivo.
2001 - 2003 Basic research of the treatment for hepatic failure by hepatocyte transplantation
2000 - 2002 Study of analysis of bile stasis using the extracorporeal hepatic tissue model and of the effect of cell transplantation on hepatic failure
肝幹細胞移植による肝再生置換療法の確立
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Papers (90)：
Ryo Ito, Koji Miyanishi, Tomohiro Kubo, Kota Hamaguchi, Takahiro Osuga, Shingo Tanaka, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada, Minoru Nagayama, et al. Synergistic antitumor effect of histone deacetylase class IIa inhibitor with lenvatinib in hepatocellular carcinoma. Hepatology international. 2023. 17. 3. 735-744
