Rchr
J-GLOBAL ID:200901064221410498
Update date: Jun. 19, 2024
Yanai Hikaru
Yanai Hikaru
Affiliation and department:
Job title:
Associate Professor
Homepage URL (1):
https://tupls-matsumotoken.jimdofree.com/
Research field (3):
Pharmaceuticals - chemistry and drug development
, Synthetic organic chemistry
, Structural/physical organic chemistry
Research keywords (4):
Physical Organic Chemistry
, Organofluorine Chemistry
, Synthetic Organic Chemistry
, Acid Catalysis
Research theme for competitive and other funds (19):
- 2023 - 2026 Improvement of cell membrane permeability by fluorineted carbanion substitutents
- 2023 - 2026 Development of functional molecules bearing stable carbanion moieties
- 2020 - 2023 Development of novel cascade reactions for polysubstituted polycyclic aromatics
- 2022 - Development of novel fluorinated substituents deirected to medicinal chemistry
- 2019 - 2020 蛍光色素の水溶性と脂溶性を制御する新手法の開発
- 2017 - 2020 Structural chemistry on highly stabilized carbanions
- 2015 - 2019 強酸性炭素酸とその共役塩基に着目した新触媒の開発
- 2017 - 2018 連続反応を活用した多置換多環式芳香族化合物の合成
- 2015 - 2017 高度に分極したアルケンの構造と反応性に立脚した触媒作用の探求
- 2014 - 2017 Novel cascade reactions triggered by silyl acetal activation
- 2014 - 2016 Development of strongly acidic organocatalysts
- 2015 - 2016 新しい酸性官能基の開発と触媒作用の探求
- 2012 - 2014 Development of novel acidic functionality directed to design of organocatalysts
- 2012 - 2014 Development of superacidic carbon acids: synthesis, characterization, and catalyst activity
- 2010 - 2012 Development of new synthetic reactions based on novel acid catalysts
- 2011 - 2011 ビス(トリフルオロメチルスルホニル)メチル基を有する高活性酸触媒の開発
- 2008 - 2010 Preparation of functionalized organofluorine compounds toward drug discovery
- 2007 - 2009 Development of functional molecules on the basis of design of novel Lewis acid catalysts
- 2005 - 2007 Development of synthetic methodogies for organofluorine compounds in medicinal chemistry
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Papers (79):
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S. Hoshikawa, J. M. Alonso, T. Matsumoto, H. Yanai, P. Almendros. Gold-catalyzed orthogonal and chemocontrolled synthesis of [4-7-6] tricycles from 1,5-diynes. Advanced Synthesis & Catalysis. 2024. 366. accepted
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T. Kawazoe, H. Yanai, T. Fukuhara, Y. Kanatani, A. Imakhlaf, B. Witulski, T. Matsumoto. Ring rearrangement reactions of 4-alkenylisocoumarins and photophysical evaluation of multi-substituted anthracene products. Chemistry - A European Journal. 2024. 30. e202401965
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M. Ghashghaee, B. Kaboudin, F. Kazemi, M. Hassan, H. Fukaya, H. Yanai. Synthesis of 6H-chromeno[4,3-b]quinolin-7- ylphosphonates through three component phosphonylation of coumarin carbaldehyde and their antimicrobial and photophysical properties. The Journal of Organic Chemistry. 2024. 89. 11. 7662-7670
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H. Yanai, S. Kurogi, S. Hoshikawa, T. Matsumoto. HFIP-mediated desulfinative Friedel-Crafts cyclobutenylation reaction. Chemistry - A European Journal. 2024. 30. e202400843
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B. Kaboudin, H. Esfandiari, M. Kakavand, M. Sohrabi, E. Yousefian Amirkhiz, A. Nesha, T. Kawazoe, H. Fukaya, H. Yanai. Phosphite-imidazole catalyzed <i>N</i>-formylation and <i>N</i>-acylation of amines. Organic & Biomolecular Chemistry. 2023. 21. 40. 8182-8189
more...
MISC (7):
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H. Yanai. Hirshfeld Atom Refinement. Yuki Gosei Kagaku Kyokaishi. 2022. 80. 3. 281-281
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Hikaru Yanai. Development of novel synthetic reactions though specific properties of fluorine and fluorine-containing substituents. Chemical Industry. 2019. 70. 8. 8-14
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矢内 光. 連続反応を活用した多置換多環式芳香族化合物の合成. 上原記念生命科学財団研究報告集. 2018. 32. 108
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Yanai, H. Synthesis of carbanion-containing salts and their applications as novel organocatalysts. Chemical Industry. 2017. 68. 9. 73-78
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Yanai, H. Superacidic carbon acids: Synthesis and catalysis. Fine Chemicals. 2017. 46. 3. 21-28
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Patents (5):
Books (7):
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<i>Green Synthetic Approaches for Biologically Relevant Heterocycles</i> (Second Edition), Volume 2: Green Catalytic Systems and Solvents; G. Brahmachari (Ed.)
Elsevier 2021 ISBN:9780128207925
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Development of Organocatalysts and Their Application to Industry; T. Akiyama (Ed.)
CMC Publishing 2018 ISBN:9784781313238
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フッ素化学入門2015
三共出版 2015 ISBN:9784782707272
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<I>Green Synthetic Approaches for Biologically Relevant Heterocycles</I>; G. Brahmachari (Ed.)
Elsevier: Amsterdam 2014 ISBN:9780128000700
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パートナー薬品製造学 改訂第2版,野上靖純,田口武夫,長 普子(編集)
南江堂 2012 ISBN:4524402942
more...
Lectures and oral presentations (85):
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Controlling the solubility profiles of polycyclic aromatic compounds by carbanionic substituents
(International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023, Bali, Indonesia)
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Fluorinated stable carbanions as substituents for controlling the solubility profiles of organic compounds
(23rd International Symposium on Fluorine Chemistry, Québec City, Canada 2023)
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HFIP-mediated detriflylative allylic substitution reactions on the cyclobutene platform
(23rd International Symposium on Fluorine Chemistry, Québec City, Canada 2023)
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The fluorine magic in drug discovery
(Departmental seminar at Toyohashi University of Technology 2022)
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Ring-rearrangement strategy for selective synthesis of pseudo aromatic polyketides
(International Congress on Pure & Applied Chemistry (ICPAC), Kota Kinabalu, Malaysia 2022)
more...
Education (2):
- 2002 - 2005 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmaceutical Sciences
- 1998 - 2002 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Division of Pharmaceutical Sciences
Professional career (1):
- Doctor of Philosophy (Tokyo University of Pharmacy and Life Science)
Work history (7):
- 2016/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Associate Professor
- 2013/04 - 現在 Tokyo University of Agriculture and Technology Lecturer (part-time)
- 2018/09 - 2018/10 Université Caen-Normandie Invited Professor
- 2014/07 - 2016/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Senior Lecturer
- 2008/09 - 2014/06 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Assistant Professor
- 2013/10 - 2013/12 Université Claude Bernard Lyon 1-CNRS Visiting Researcher
- 2005/04 - 2008/07 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Research Assistant
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Committee career (9):
- 2023/08 - 現在 日本フッ素化学会 産学連携部会 学界会員
- 2023/08 - 現在 有機合成化学協会 第40回有機合成化学セミナー実行委員
- 2023/05 - 現在 日本フッ素化学会 企画委員
- 2023/03 - 現在 The Society of Synthetic Organic Chemistry, Japan Editorial Board of J. Synth. Org. Chem., Jpn.
- 2020 - 現在 The Society of Fluorine Chemistry, Japan Editorial Board of "Fluorine"
- 2022 - 2023 日本フッ素化学会 第11回フッ素化学若手の会実行委員長
- 2008 - 2015 日本薬学会 次世代を担う有機化学シンポジウム世話人
- 2010 - 2011 日本フッ素化学会 第1回フッ素化学若手の会実行委員
- 2009 - 2010 日本薬学会 第3回日本薬学会関東支部若手シンポジウム実行委員
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Awards (6):
Association Membership(s) (5):
THE CHEMICAL SOCIETY OF JAPAN
, American Chemical Society
, 日本フッ素化学会
, The Society of Synthetic Organic Chemistry, Japan
, The Pharmaceutical Society of Japan
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