Rchr
J-GLOBAL ID:200901064272875614
Update date: Jan. 31, 2024
Kawabata Takeo
カワバタ タケオ | Kawabata Takeo
Affiliation and department:
Job title:
Professor
Research field (4):
Pharmaceuticals - chemistry and drug development
, Synthetic organic chemistry
, Bioorganic chemistry
, Structural/physical organic chemistry
Research keywords (12):
位置選択的官能基化
, remote asymmetric induction
, natural glycoside
, インターロック分子
, 動的不斉
, 有機合成化学
, Site-selective Catalysis
, Remote Asymmetric Induction
, Natural Glycoside
, Interlocked Molecule
, Dynamic Chirality
, Synthetic Organic Chemistry
Research theme for competitive and other funds (41):
- 2021 - 2024 Asymmetric construction of interlocked molecules by remote asymmetric induction
- 2017 - 2020 Asymmetric Synthesis of Supramolecules by Organocatalysis
- 2014 - 2019 Regioselective Molecular Transforamtion of Mutifunctionalized Molecules
- 1989 - 2018 生理活性物質の合成
- 1989 - 2018 Synthesis of Biologically Active Products
- 2013 - 2016 配糖体天然物の短段階位置選択的全合成
- 2011 - 2016 Regioselective Functionalization by Organocatalysis
- 2013 - 2015 Regioselective Cleavage of Peptides by Organocatalysis
- 2010 - 2015 An Approach to Novel Structural Design by Combining Discrete Methods and Kernel Methods
- 2009 - 2012 Fine Organic Synthesis based on Catalytic Regioselective Functionalization
- 2010 - 2011 有機触媒を用いる精密分子変換法の開発
- 2001 - 2010 RS型オリゴマーの構造と機能
- 2001 - 2010 Structure and Functions of RS-oligomers
- 2007 - 2009 New Methods for Designing Chemical Structures Using Graph Theory and Kernel Methods
- 2007 - 2008 水素結合を介するビナフチルの創製
- 2006 - 2008 Fine Organic Synthesis with Nucleophilic Catalysts
- 2005 - 2008 Development of Advanced Asymmetric Molecular Transformation with Functionalized Carbanions
- 1995 - 2008 求核触媒を用いる不斉反応
- 1990 - 2008 不斉記憶に基づく不斉誘導
- 1990 - 2008 Asymmetric Synthesis by Nucleophilic Catalysis
- 1990 - 2008 Asymmetric Induction based on Memory of Chirality
- 2005 - 2007 不斉記憶型環化を利用する多置換複素環の合成
- 2006 - 2006 酸・塩基複合型有機触媒の精密設計
- 2004 - 2005 C2-対称不斉求核触媒の開発及び不斉炭素-炭素結合形成反応への利用
- 2002 - 2004 Development of a New Generation of Nucleophilic Catalysts and their Use in Selective Reactions
- 2002 - 2003 新世代不斉求核触媒の開発
- 2002 - 2003 エノレートの動的不斉を利用する不斉環化反応
- 1999 - 2001 Asymmetric Synthesis with Chiral Nucleophilc Catalysts
- 1998 - 2000 Stereocontrol utilizing intermolecular interaction
- 1998 - 1999 抗腫瘍活性を志向した中国産植物成分の化学的研究
- 1997 - 1998 Development of Chiral Nucleophilic Catalysts
- 1996 - 1996 エノレートの動的不斉に基づく不斉反応の開発と解析
- 1994 - 1996 抗腫瘍活性ジテルペノイドの検索、構造並びに化学変換に関する研究
- 1995 - 1995 外部不斉源を用いないα-アミノ酸誘導体の不斉α-アルキル化反応
- 1994 - 1995 Creation of Novel Axially-Chiral Compounds : Developments toward Asymmetric Synthesis
- 1993 - 1993 キラルアジリジンを用いる生理活性天然物の合成
- 1992 - 1992 不斉記憶に基づくエノレートの不斉アルキル化反応
- 1991 - 1992 Basic Studies and Synthetic Application of Enzyme Functions
- 1991 - 1991 エナンチオ選択的ハロラクトン化反応
- 1990 - 1990 複数の活性中心を持つ抗癌医薬品の分子設計
- 1988 - 1989 Construction of Chiral Building Blocks through Enantioselective Protonation
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Papers (255):
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Koki Fujimura, Yoshihiro Ueda, Yousuke Yamaoka, Kiyosei Takasu, Takeo Kawabata. Rotaxane Synthesis by an End-Capping Strategy via Swelling Axle-Phenols. Angewandte Chemie (International ed. in English). 2023. e202303078
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Naruhiro Gondo, Koki Fujimura, Ryuichi Hyakutake, Yoshihiro Ueda, Takeo Kawabata. Organocatalytic regio- and enantioselective vinylogous aza-Morita-Baylis-Hillman reaction. Tetrahedron Letters. 2023. 115. 154306-154306
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Hisashi Hashimoto, Yoshihiro Ueda, Koki Fujimura, Kiyosei Takasu, Takeo Kawabata. Approach Toward Reversal of Chemoselectivity in Catalytic Silylation of Pyranosides. European Journal of Organic Chemistry. 2022. 2022. 37
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Takuya Murai, Yongning Xing, Mayu Kurokawa, Toshifumi Kuribayashi, Masanori Nikaido, Elghareeb E. Elboray, Shohei Hamada, Yusuke Kobayashi, Takahiro Sasamori, Takeo Kawabata, et al. One-Pot Preparation of (NH)-Phenanthridinones and Amide-Functionalized [7]Helicene-like Molecules from Biaryl Dicarboxylic Acids. Journal of Organic Chemistry. 2022. 87. 9. 5510-5521
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Hisashi Hashimoto, Yoshihiro Ueda, Kiyosei Takasu, Takeo Kawabata. Catalytic Substrate-Selective Silylation of Primary Alcohols via Remote Functional-Group Discrimination. Angewandte Chemie International Edition. 2022
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MISC (302):
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藤村光揮, 上田善弘, 高須清誠, 川端猛夫, 川端猛夫. Synthesis of rotaxanes via halogenation of axle component. 日本薬学会年会要旨集(Web). 2022. 142nd
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上田善弘, 橋本悠, 高須清誠, 川端猛夫, 川端猛夫. Catalytic Substrate-Selective Silylation of Primary Alcohols via Remote Functional Group Recognition. 日本薬学会年会要旨集(Web). 2022. 142nd
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橋本悠, 繁田尭, 平田篤志, 吉田圭祐, 今吉亜由美, 上田善弘, 川端猛夫. 分子認識型触媒を用いる長鎖σ-対称ジオール及びジアミンの遠隔位不斉非対称化. シンポジウム「モレキュラー・キラリティー」講演要旨集. 2018. 2018
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上田善弘, 繁田尭, 橋本悠, GHOSH Harisadhan, 藤本匠, 平田篤志, 吉田圭祐, 今吉亜由美, 川端猛夫. 官能基間距離認識によるσ-対称ジオールの触媒的遠隔位不斉非対称化. 反応と合成の進歩シンポジウム講演要旨集. 2018. 44th
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繁田尭, 吉田圭佑, 古田巧, 川端猛夫. 遠隔位認識型アシル化触媒を用いたσ-対称鎖状ジオールの不斉非対称化. 次世代を担う有機化学シンポジウム講演要旨集. 2014. 12th
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Patents (10):
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アルドール反応触媒
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METHOD FOR PRODUCING OPTICALLY ACTIVE α-FLUORO AMINO ACID COMPOUND OR SALT THEREOF
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β-ラクタム化合物およびその製造方法
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酸化触媒
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アミノ酸誘導体およびその製造方法
more...
Books (5):
-
evelopment of Organocatalysts and Their Application to Industry
CMC Publishing CO., LTD 2018 ISBN:9784781313238
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Synthesis Technology of Peptides, Nucleic Acids and Sugar Chains for Medium Molecule Drug Discovery
CMC Publishing CO., LTD 2018 ISBN:9784781313207
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Springer Interntional Publishing
Springer Interntional Publishing 2016 ISBN:9783319263335
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Sustainable Catalysis
RSC Green Chemistry, Sustainable Catalysis 2015 ISBN:9781782620587
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進化を続ける有機触媒 有機合成を確信する第三の触媒
化学同人 2009 ISBN:9784759807516
Lectures and oral presentations (369):
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N-Cbzアミノ酸誘導体のenentiodivergentな分子内不斉アルキル化反応
(The 140th Annual meeting of the Pharmaceutical Society of Japan 2020)
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官能基間距離認識を基盤とする長鎖σ対称ジオールの触媒的シリル化による遠隔位不斉非対称化
(The 140th Annual Meeting of the Pharmaceutical Society of Japan 2020)
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C(sp2)-H結合アミノ化による不斉非対称化に基づく分子不斉カリックスアレーンの触媒的不斉合成
(The 140th Annual Meeting of the Pharmaceutical Society of Japan 2020)
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Pdドミノカップリングによるアミド官能化[7]ヘリセンの簡便合成
(The 140th Annual Meeting of the Pharmaceutical Society of Japan 2020)
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C(sp2)-H結合アミノ化によるmechanically planar chiralロタキサンの不斉合成
(The 140th Annual Meeting of the Pharmaceutical Society of Japan 2020)
more...
Works (2):
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光学活性異常アミノ酸の合成
2000 - 2006
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Synthesis of optically active unusual amino acids
2000 - 2006
Education (2):
- 1978 - 1983 Kyoto University
- 1974 - 1978 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1):
- Doctor of Pharmaceutical Science (Kyoto University)
Work history (8):
- 2021/03 - 現在 International University of Health and Welfare
- 2004/04 - 2021/03 京都大学化学研究所、教授
- 1998/06 - 2004/03 京都大学化学研究所、助教授
- 1989/04 - 1998/05 京都大学化学研究所、助手
- 1985 - 1989 相模中央化学研究所,研究員
- 1985 - 1989 Sugami Chemical Resarch Center, Researcher
- 1983 - 1985 米国インディアナ大学博士研究員
- 1983 - 1985 Dostdoctoral Fellow, Indiana University
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Committee career (1):
Awards (6):
- 2018/04 - MEXT Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
- 2017/03 - The pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award '17
- 2012/06 - Molecular Chirality Research Organization Molecular Chirality Award
- 2006/09 - Tetrahedron Letters Elsevier Limited Tetrahedron Letters Most Cited Paper 2003-2006 Award
- 1996/04 - The Society of Synthetic Organic Chemistry, Japan Eisai's Planning Award
- 1995/03 - The pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award for Young Scientists '95
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Association Membership(s) (5):
アメリカ化学会
, 有機合成化学協会
, 日本化学会
, 日本薬学会
, American Chemical Society
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