Imaoka Susumu

イマオカススム | Imaoka Susumu

Affiliation and department：
Job title： professor
Homepage URL (1)： http://sci-tech.ksc.kwansei.ac.jp/~imaoka/

Research field (4)： Pathobiochemistry , Pharmaceuticals - health and biochemistry , Structural biochemistry , Molecular biochemistry

Research keywords (10)：チトクロームP450 , 活性酸素 , 低酸素 , 薬物 , 酸素センサー , 環境ホルモン , active oxygen , drug metabolism , hypoxia , environmental endocrine disrupting chemical

Research theme for competitive and other funds (21)：

2019 - 2022 味の知覚に対する相互作用のモデル化と感性を考慮した推薦システムの構築
2017 - 2020 New regulation mechanism of Nrf2 (SKN-1) and Effects of these factors on lifespan elongation.
2016 - 2019 Analysis of biological functions and transcriptional regulation of soluble epoxide hydrolase (sEH) in diabetes
2013 - 2016 The mechanism behind the disruption of Thyroid hormone receptor (THR) activity via PDI by BPA
2011 - 2012 Protein interference in mammalian cells and analysis of biological functions of PDI and sEH

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Papers (171)：

Akiyoshi Tamura, Ferbian Milas Siswanto, Takumi Yoshimura, Ami Oguro, Susumu Imaoka. Hydrogen Peroxide Induces Ethanol-inducible CYP2E1 via the NF-kB-classical Pathway: CYP2E1 mRNA Levels are not High in Alcoholic Hepatitis. Current drug metabolism. 2024. 25. 5. 307-316
Ferbian Milas Siswanto, Kenta Okukawa, Akiyoshi Tamura, Ami Oguro, Susumu Imaoka. Hydrogen peroxide activates APE1/Ref-1 via NF-κB and Parkin: a role in liver cancer resistance to oxidative stress. Free Radical Research. 2023. 57. 3. 223-238
Ferbian Milas Siswanto, Maria Dara Novi Handayani, Rita Dewi Firmasyah, Ami Oguro, Susumu Imaoka. Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9). Current drug metabolism. 2023. 24. 9. 667-681
Ferbian Milas Siswanto, Yumi Mitsuoka, Misato Nakamura, Ami Oguro, Susumu Imaoka. Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia. Scientific reports. 2022. 12. 1. 21265-21265
Ferbian Milas Siswanto, Akiyoshi Tamura, Rika Sakuma, Susumu Imaoka. Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway. Molecular Pharmacology. 2022. 101. 4. 257-273

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MISC (130)：

Ami Oguro, Shoko Oida, Susumu Imaoka. Down-Regulation of Soluble Epoxide Hydrolase by Sp1 under High Glucose Condition. FREE RADICAL BIOLOGY AND MEDICINE. 2012. 53. S34-S34
Haruka Morimoto, Ami Oguro, Susumu Imaoka. Mechanism of Suppression of Nrf2 Under Hypoxia. FREE RADICAL BIOLOGY AND MEDICINE. 2012. 53. S31-S32
奥村正樹, 橋本翔子, 縄田万理奈, 油谷克英, 引間孝明, 浜田大三, 日高雄二, 伊藤廉, 志波公平, 今岡進, et al. 内分泌撹乱物質によるプロテインジスルフィドイソメラーゼの構造変化. 日本蛋白質科学会年会プログラム・要旨集. 2012. 12th
Susumu Imaoka, Ami Oguro, Sachiko Suzuki. Contribution of epoxyeicosatrienoic acids (EETs) to hypoxic response of cells. CHEMISTRY AND PHYSICS OF LIPIDS. 2011. 164. S35-S35
Ami Oguro, Koichi Sakamoto, Susumu Imaoka. Proliferation of cancer cells is mediated by EET production. CHEMISTRY AND PHYSICS OF LIPIDS. 2011. 164. S32-S33

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Books (2)：

P450の精製法ーその抗体調製法及び免疫定量法
薬物代謝酵素(廣川書店) 2001
血管作動物質の分子生物学(アラキドン酸からチトクロームP450によって産生される生理活性物質(HETE, EET)
日本臨牀増刊号高血圧(上)(日本臨牀社) 2000

Works (2)：

プラスミド導入による抗体作製
2004 -
ヒト血管再構築
2003 -

Education (4)：

- 1981 Osaka University
- 1981 Osaka University Graduate School, Division of Natural Science Organic Chemistry
- 1979 Osaka University School of Science Department of Chemistry
- 1979 Osaka University Faculty of Science Chemistry

Professional career (2)：

Ph.D. (Osaka University)
医学博士 (大阪市立大学)

Committee career (1)：

日本薬物動態学会評議員

Awards (2)：

1998 - 日本薬物動態学会奨励賞
1988 - 大阪市医学会市長賞

Association Membership(s) (4)：

日本トキシコロジー学会 , 日本薬物動態学会 , 日本分子生物学会 , 日本生化学会

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