Nishimatsu Shin-ichiro

ニシマツシンイチロウ | Nishimatsu Shin-ichiro

Affiliation and department：

Research field (1)： Functional biochemistry

Research theme for competitive and other funds (22)：

2020 - 2024 脳梗塞後リハビリテーションによる大脳基底核経路ネットワーク改変メカニズムの解明
2020 - 2024 Control of Head and neck cancer by inhibitory peptides for DKK3 functional domain.
2020 - 2023 nNOS活性化による筋ジストロフィー疾患修飾効果の検討
2018 - 2021 Development of an innovative biomarker for muscle cell damage
2017 - 2020 Therapeutic study of sarcopenia by TGF-beta inhibition strategy

2016 - 2020 Tumor control targeting specific cancer-associated gene, DKK3 in squamous cell carcinoma

2015 - 2018 Regulation of caveolin-3 on pathomechanisms leading to muscular dystrophies

2014 - 2017 Development of an inhibitory peptide for myostatin: its implications for muscular dystrophy and sarcopenia

2010 - 2012 Regulation of cellular behavior of cranial neural crest during medial cartilage formation of the skull base

2008 - 2010 Axial patterning by a prohormone converting enzyme, PC6

2007 - 2009 Roles of Tbx22 during early stage of secondary palate development.

2004 - 2006 Investigation of the mechanism of paraquat toxicity -Identification of the genes which are breakthrough for the toxicity-

2001 - 2003 Identification and their function of paraquat-induced unknown genes in rat lungs.

2001 - 2003 Signaling factor interaction affecting Shh, Wnt, and BMP expression during pattern formation in the developimg limb

2001 - 2002 Analysis of body axix formation using Xenopus egg fragments as assay system for investigating gene functions

2001 - 2001 四肢パターン形成におけるBMP,Wntシグナリングの役割

2000 - 2000 四肢形態形成におけるWntシグナリング

1998 - 2000 Determination of positional identity during limb development and regeneration

1999 - 1999 四肢パターン形成におけるWntおよびBMPシグナリング

1998 - 1998 四肢パターン形成におけるShh-Wnt-BMPの相互関係

1993 - 1993 両生類初期胚におけるアクチビン受容体の情報伝達機構の解析

1991 - 1992 Studies on the role of growth factors in embryonic inductions

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Papers (87)：

Naoki Katase, Shin-ichiro Nishimatsu, Akira Yamauchi, Shinji Okano, Shuichi Fujita. DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database. Journal of Oral Biosciences. 2023
Yutaka Ohsawa, Hideaki Ohtsubo, Asami Munekane, Kohei Ohkubo, Tatsufumi Murakami, Masahiro Fujino, Shin-Ichiro Nishimatsu, Hiroki Hagiwara, Hirotake Nishimura, Ryuki Kaneko, et al. Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia. The American journal of pathology. 2023. 193. 5. 591-607
片瀬直樹, 西松伸一郎, 山内明, 岡野慎士, 藤田修一. DKK3相補性ペプチドによる頭頸部癌制御. Medical Science Digest. 2023. 49. 4. 214-216
Naoki Katase, Shin-ichiro Nishimatsu, Akira Yamauchi, Shinji Okano, Shuichi Fujita. Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC). Cancer Cell International. 2022. 22. 1
Yutaka Ohsawa, Hideaki Ohtsubo, Yoshihiko Saito, Shinichiro Nishimatsu, Hiroki Hagiwara, Tatsufumi Murakami, Ichizo Nishino, Yoshihide Sunada. Caveolin 3 suppresses phosphorylation-dependent activation of sarcolemmal nNOS. Biochemical and Biophysical Research Communications. 2022

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MISC (40)：

片瀬直樹, 西松伸一郎, 山村真弘, 山内明. DKK3 regulates malignant property of head and neck squamous cell carcinoma via phosphorylation of Akt. 日本癌学会学術総会抄録集(Web). 2020. 79th
大澤裕, 丹田和恵, 深井雄太, 藤野雅広, 西松伸一郎, 砂田芳秀. マイオスタチンペプチド医薬によるデュシェンヌ型筋ジストロフィー治療法の基盤研究. 日本筋学会学術集会プログラム・抄録集. 2018. 4回. 178-178
砂田芳秀, 大澤裕, 西松伸一郎, 萩原宏毅, 後藤雄一, 太田成男. タウリンによるMELAS脳卒中様発作再発防止長期治験成績. 日本筋学会学術集会プログラム・抄録集. 2018. 4th. 77
深井雄太, 大澤裕, 大坪秀明, 西松伸一郎, 萩原宏毅, 野田亮, 笹岡俊邦, 村上龍文, 砂田芳秀. サルコグリカン欠損筋におけるβ-ジストログリカンプロセッシング. 日本筋学会学術集会プログラム・抄録集. 2018. 4th. 161
Tomoyuki Mukai, Takafumi Mito, Shunichi Fujita, Shoko Kodama, Akiko Nagasu, Teruki Sone, Shinichiro Nishimatsu, Yutaka Ohsawa, Yoshihide Sunada, Yoshitaka Morita. The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models. ARTHRITIS & RHEUMATOLOGY. 2017. 69

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Books (4)：

サルコペニアに対する新規治療薬の可能性を探る:マイオスタチン阻害薬「サルコペニアとフレイル」
医薬ジャーナル社 2015
四肢の発生と再生「発生・神経研究の最前線2000:実験医学増刊」
羊土社 2000 ISBN:4897060788
骨形成因子BMPと体軸形成「細胞増殖因子研究の最前線'97-'98:実験医学増刊」
羊土社 1997 ISBN:4897060567
Mesoderm induction in early amphibian embryos by activin A and its related gene products in Xenopus laevis「Frontiers in Muscle Research: Myogenesis, Muscle Contraction and Muscle Dystrophy」
Elsevier Science Publishers 1991 ISBN:044481390X

Lectures and oral presentations (117)：

Establishment of a newly isolated triploid clone of <I>Spirometra</I> (Cestoda: Diphyllobothriidae) as a powerful tool for studying the molecular and cellular bases of sparganosis
(14th International Congress of Parasitology 2018)
からだのサイズと細胞のサイズを調節するメカニズムの解明
(日本筋学会第4回学術集会 2018)
創傷治癒促進形質MRLはデュシェンヌ型筋ジストロフィーモデルの骨格筋病変を改善する
(日本筋学会第4回学術集会 2018)
タウリンによるMELAS脳卒中様発作再発防止長期治験成績
(日本筋学会第4回学術集会 2018)
サルコグリカン欠損筋におけるβ-ジストログリカンプロセッシング
(日本筋学会第4回学術集会 2018)

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Education (2)：

1986 - 1990 University of Tsukuba Graduate School, Division of Agriculture
1982 - 1986 University of Tsukuba Second Cluster of College

Work history (3)：

1994 - 1997 Researcher
1990 - 1994 Research Assistant
1990 - 1990 Researcher

Awards (2)：

2012/06 - 川崎医科大学澤山賞
1993/10 - 財団法人筑波学都資金財団教育研究特別表彰

Association Membership(s) (8)：

Japan Society for Medical Education , Japanease Cancer Association , Japan Muscle Society , The Zoological Society of Japan , Society for Developmental Biology , 日本発生生物学会 , 日本生化学会 , 日本分子生物学会

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