Rchr
J-GLOBAL ID:200901064942678998   Update date: Jan. 31, 2024

Kohno Kenji

コウノ ケンジ | Kohno Kenji
Homepage URL  (1): http://www.naist.jp/iri/kouno/
Research field  (3): Molecular biology ,  Cell biology ,  Applied biochemistry
Research keywords  (9): 小胞体ストレス応答 ,  Protein Quality Control ,  新生鎖における翻訳ポージング ,  糖尿病と小胞体ストレス ,  毒素受容体を利用した標的細胞ノックアウト(TRECK) ,  肝再生移植 ,  疾患モデルマウス ,  転写・翻訳調節 ,  シグナル伝達
Research theme for competitive and other funds  (47):
  • 2015 - 2020 International Activities Supporting Group for Nascent Chain Biology
  • 2017 - 2020 細胞や生体の恒常性維持に必要な生理的小胞体ストレス応答機構の解明
  • 2014 - 2019 Nascent-Chain Biology
  • 2014 - 2019 mRNAの局在化に働く新生鎖の機能解析
  • 2012 - 2017 小胞体ストレス応答の分子機構とその破綻による疾患機序の解明
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Papers (175):
  • Ashuei Sogawa, Ryota Komori, Kota Yanagitani, Miku Ohfurudono, Akio Tsuru, Koji Kadoi, Yukio Kimata, Hiderou Yoshida, Kenji Kohno. Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α. Cell structure and function. 2023. 48. 2. 211-221
  • Takahiro Fukaishi, Yuko Nakagawa, Ayako Fukunaka, Takashi Sato, Akemi Hara, Keiko Nakao, Michiko Saito, Kenji Kohno, Takeshi Miyatsuka, Motoyuki Tamaki, et al. Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice. Diabetologia. 2021. 64. 12. 2803-2816
  • Jun Watanabe, Yuki Takayanagi, Masahide Yoshida, Tatsuya Hattori, Michiko Saito, Kenji Kohno, Eiji Kobayashi, Tatsushi Onaka. Conditional ablation of vasopressin-synthesizing neurons in transgenic rats. Journal of neuroendocrinology. 2021. 33. 12. e13057
  • Quynh Giang Le, Yuki Ishiwata-Kimata, Thi Huong Phuong, Shigeto Fukunaka, Kenji Kohno, Yukio Kimata. The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress. Scientific reports. 2021. 11. 1. 4506-4506
  • Caroline C Duwaerts, Kevin Siao, Russell K Soon Jr, Chris Her, Takao Iwawaki, Kenji Kohno, Aras N Mattis, Jacquelyn J Maher. Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α. Cell death and differentiation. 2020. 28. 5. 1455-1465
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MISC (35):
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Patents (2):
  • Knockout Animals
  • Knockout Animals
Works (6):
  • 毒素レセプターを利用した標的細胞ノックアウト法の開発と応用
    2002 -
  • Toxin receptor mediated conditional & targeted cell knockout method
    2002 -
  • 小胞体ストレスと神経細胞死
    2001 -
  • ER stress and neural degenerated disease
    2001 -
  • 普遍的な生体防御機構としてのストレス応答
    1996 - 2000
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Education (4):
  • 1977 - 1980 The university of Tokyo Graduate School of Agricultural and Life Sciences
  • 1975 - 1977 University of Tokyo Faculty of Agricultural Chemistry
  • 1973 - 1975 The University of Tokyo
  • 1971 - 1973 University of Tokyo
Professional career (1):
  • Dr. of Agriculture
Work history (10):
  • 2019/09 - 現在 兵庫県立大学大学院 生命理学研究科 特任教授
  • 2017/04 - 2020/03 Nara Institute of Science and Technology Institute for Research Initiatives Professor
  • 2005/04 - 2017/03 Nara Institute of Science and Technology Graduate School of Biological Sciences Professor
  • 2003 - 2011/03 The Open University of Japan
  • 1993/05 - 2005/03 Nara Institute of Science and Technology Research and Education Center of Genetic Information Professor
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Committee career (3):
  • 日本農芸化学会 関西支部評議員・参与・代議員・授賞選考委員会委員
  • 日本生化学会 評議員
  • 日本細胞生物学会 理事・代議員・評議員・運営委員
Awards (3):
  • 2013/04 - 文部科学省 科学技術分野の文部科学大臣表彰 科学技術賞(研究部門)
  • 2012/03 - 日本農芸化学会 日本農芸化学会賞
  • 2002/04 - 第2回バイオビジネスコンペJapan優秀賞
Association Membership(s) (13):
American Society for Biochemistry and Molecular Biology ,  日本農芸化学会 ,  日本分子生物学会 ,  日本生化学会 ,  日本細胞生物学会 ,  and Agrochemistry ,  Biotechnology ,  Japan Society for Bioscience ,  The Molecular Biology Society of Japan ,  The Japanese Biochemical Society ,  Japan Society for Cell Biology ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  American Society for Cell Biology
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