Rchr
J-GLOBAL ID：200901065005977919
Update date: Jun. 30, 2020
Naomi Shimokawa
チバ ナオミ | Naomi Shimokawa
Research field (2)：
Immunology
, Molecular biology
Research theme for competitive and other funds (3)：
YidCによる透過孔に依存しないタンパク質膜組込機構:YidCが膜内に作り出す親水性微小環境とその重要性
High-affinity receptor for IgE (FcRI) which is composed of -chain, -chain and - chain, is expressed on mast cell and plays important roles in allergic reactions. Previously, we found that transcription fa・・・
これまでに我々は高親和性IgE 受容体(FcRI)鎖の遺伝子発現において転写因子GATA-1,PU.1が協調的に働き細胞特異的な発現が制御されていること、PU.1 の発現量がマスト細胞と樹状細胞(DC)などの単球系細胞の分岐点を決定することを明らかにした。本研究ではこれら系列の細胞分化におけるGATA-1の機能を解明するため、GATA-1の発現増強がDCに及ぼす影響を調べる。
MISC (22)：
Naomi Shimokawa-Chiba, Kaoru Kumazaki, Tomoya Tsukazaki, Osamu Nureki, Koreaki Ito, Shinobu Chiba. Hydrophilic microenvironment required for the channel-independent insertase function of YidC protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015. 112. 16. 5063-5068
Mutsuko Hara, Hokuto Yokoyama, Kanako Fukuyama, Nao Kitamura, Naomi Shimokawa, Keiko Maeda, Shunsuke Kanada, Tomonobu Ito, Yoshihiko Usui, Hideoki Ogawa, et al. Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells. MOLECULAR IMMUNOLOGY. 2013. 53. 3. 295-301
Yuki Nakamura, Daisuke Harama, Naomi Shimokawa, Mutsuko Hara, Ryuyo Suzuki, Yu Tahara, Kayoko Ishimaru, Ryohei Katoh, Ko Okumura, Hideoki Ogawa, et al. Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction. The Journal of allergy and clinical immunology. 2011. 127. 4. 1038-45
Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ishimaru K, Ikegami S, Makino S, Kitamura M, Nakao A. Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. Immunol Cell Biol. 2011. 89. 7. 817-22
Naomi Shimokawa, Chiharu Nishiyama, Nobuhiro Nakano, Keiko Maeda, Ryuyo Suzuki, Mutsuko Hara, Tatsuo Fukai, Tomoko Tokura, Hiroaki Miyajima, Atsuhito Nakao, et al. Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells. IMMUNOGENETICS. 2010. 62. 7. 421-429
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Lectures and oral presentations (7)：
大腸菌由来毒素であるSubABは、UPRを惹起することでLPS誘導性の炎症反応を抑制する.
(第39回日本免疫学会総会・学術集会 2009)
Role of a transcription factor GATA-1 in commitment between dentritic cells and mast cells.
(第38回日本免疫学会総会・学術集会 2008)
Cigarette smoke extract induce TSLP expression ,leading to allergic airway inflammation.
(第58回日本アレルギー学会秋季学術大会 2008)
IL-12/23 p40 遺伝子のプロモーター領域における遺伝子多型の機能解析
(第58回日本アレルギー学会秋季学術大会 2008)
Role of a transcription factor GATA-1 in commitment between dentritic cells and mast cells.
(第37回日本免疫学会総会・学術集会 2007)
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Education (1)：
- 2005 京都大学大学院
Professional career (1)：
博士(理学) (京都大学)
Work history (1)：
University of Yamanashi Department of Research Interdisciplinary Graduate School of Medicine and Engineering, Basic Cinical Medicine,
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