Ohta Toshio

オオタトシオ | Ohta Toshio

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://muses.muses.tottori-u.ac.jp/index.html

Research field (1)： Veterinary medicine

Research theme for competitive and other funds (36)：

2022 - 2025 Functional analysis of nociceptive channels as therapeutic targets for pain
2018 - 2022 Elucidation of pathological pain via nociceptors and its application to pain relief
2015 - 2018 Evaluation of roles of polymodal receptors in non-neural cells under the inflammatory conditions
2014 - 2018 Involvement of nociceptive channels as molecular basis of neuropathic pain development
2012 - 2015 Analysis of gaseous messenger functions in the spinal dorsal horn.

2010 - 2014 Elucidation of molecular mechanisms of pathophysiological pain via nociceptive channels and establishment of pain-evaluating system

2009 - 2011 Analysis of molecular mechanisms of neuropathic pain and neciceptive signaling

2006 - 2009 Regulatory mechanisms of vanilloid receptor on pain signaling

2006 - 2007 プリオンと銅イオン相互作用の新しいパルス電子スピン共鳴法を用いたアプローチ

2004 - 2006 神経因性疼痛発生の分子機構の解明と痛覚評価系の開発に関する研究

2003 - 2005 Role of store-operated Ca entry mechanism in signal transduction in gastrointestinal intrinsic neurons

2003 - 2004 Dysfunction of neutrophil during parturition and proteome analysis of placenta and serum in cow

2002 - 2004 Molecular mechanisms of pain signal transmission and evaluation of analgesias inn vitro

2002 - 2003 抗酸化物質を用いた新たな神経突起・神経細胞分化誘導法の開発

2001 - 2002 Analysis of functional role of capacitative Ca entry in enteric neurons

2000 - 2001 Development of new antitumor drugs and apoptotic signal transudation - Application to feline leukemia and canine lymphoma -

2000 - 2001 Functional and pathphysiological study in serotonin-containing chemorecptor cells

1999 - 2000 Analysis of the store-dependent Ca entry mechanisms in adrenal chromaffin cells

1998 - 1998 薬物残留の指標としての獣毛内畜産用抗菌剤の定量

1997 - 1998 単一副腎髄質細胞におけるイノシトール3燐酸によるCa放出機構と分泌反応の解析

1995 - 1996 Intracellular signal transduction of parathyroid hormone receptor activation and its pathphysiology

1994 - 1995 Control of adrenal catecholamine secretion by Ca^<2+> storing mechanisms

1994 - 1994 平滑筋細胞の興奮性制御における新しい筋小胞体依存性カルシウム流入機構の解明

1993 - 1993 消化管壁内神経細胞膜におけるイオンチャネルの性質と制御機構の解明

1992 - 1992 平滑筋細胞のムスカリン受容体-シグナル伝達におけるClイオンチャネルの生理的役割

1991 - 1992 CHARACTERISTIC OF INTRACELLULAR CALCIUM STORES RESPONSIBLE FOR CATECHOLAMINE SECRETION IN ADRENAL MEDULLARY CHROMAFFIN CELLS

1991 - 1992 Isolation and cloning of VIP receptors.

1990 - 1990 悪性高熱症ブタの骨格筋筋小胞体Ca放出チャンネルの遺伝子解析

1988 - 1989 The etiology and therapy of muscle rigidity in pig stress syndrome.

1986 - 1987 Phosphatidylinositol breakdown and catecholamine secretion in adrenal chromaffin cells

痛みの発現機構と痛覚受容体機能解析

平滑筋細胞のCa動員機構とイオンチャネル活性

副腎髄質細胞のCa動員機構

furctional changes in vascular cell system by oxidative stress.

Ca mobilizing mechanism and ionic channel activity of smooth muscle cell

Ca mobilizing mechanism of adrenal chromaffin cell

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Papers (113)：

A Yoshimura, S Saito, C T Saito, K Takahashi, M Tominaga, T Ohta. Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae). Biochemistry and biophysics reports. 2022. 31. 101315-101315
Oguma N, Takahashi K, Okabe S, Ohta T*. Inhibitory effect of polysulfide, an endogenous sulfur compound, on oxidative stress-induced TRPA1 activation. Neurosci Lett. 2021. 757. 135982
Uzura R, Takahashi K, Saito S, Tominaga M, Ohta T*. Reduction of extracellular sodium evokes nociceptive behaviors in the chicken via activation of TRPV1. Brain Research. 2020
Shimada T, Takahashi K, Tominaga M, Ohta T*. Identification of molecular targets for toxic action by persulfate, an industrial sulfur compound. Neurotoxicol. 2019. 72. 29-37
Nishizawa Y, Takahashi K, Oguma N, Tominaga M, Ohta T*. Possible involvement of transient receptor potential ankyrin 1 in Ca2+ signaling via T-type Ca2+ channel in mouse sensory neurons. J Neurosci Res. 2018. 96. 901-910

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MISC (44)：

Delgermurun Dugar, Shigeo Ito, Soichiro Yamaguchi, Toshio Ohta, Ken-ichi Otsuguro. Effects of 5-HT uptake inhibitors and amphetamine derivatives on 5-HT outflow from chicken aortic body. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S190-S190
Nagako Banzawa, Shigeru Saito, Kenji Takahashi, Makiko Kashio, Makoto Tominaga, Toshio Ohta. Identification of molecular basis determining inhibition/activation of nociceptive receptor TRPA1 by utilizing species differences. GENES & GENETIC SYSTEMS. 2014. 89. 6. 297-297
Shigeru Saito, Masashi Ohkita, Claire T. Saito, Naomi Fukuta, Toshio Ohta, Makoto Tominaga. Molecular basis for the functional change in the heat sensor TRPV1 between two Xenopus species inhabiting different thermal environments. GENES & GENETIC SYSTEMS. 2014. 89. 6. 298-298
Hitomi Ogawa, Yukari Hatakeyama, Kenji Takahashi, Makoto Tominaga, Hideo Kimura, Toshio Ohta. Nociceptive action of hydrogen sulfide through the activation of transient receptor potential ankyrin 1 (TRPA1). NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2014. 39. S13-S13
Tatsuki Kaimoto, Kenji Takahashi, Shigeru Saito, Makoto Tominaga, Toshio Ohta. Involvement of nociceptive TRPA1 channel in analgesic action of Limonene. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 155P-155P

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Education (4)：

- 1984 Hokkaido University
- 1984 Hokkaido University Graduate School, Division of Veterinary Medicine
- 1982 Hokkaido University School of Veterinary Medicine Veterinary Medicine
- 1982 Hokkaido University Faculty of Veterinary Medicine

Professional career (1)：

(BLANK) (Hokkaido University)

Work history (8)：

2019/04 - 現在 Tottori University
2009/04 - 現在 Yamaguchi University Graduate School The United Graduate School of Veterinary Sciences
2009/04 - 現在 Tottori University Faculty of Agriculture
2007/04 - 2009/03 Hokkaido University Graduate School of Veterinary Medicine
1997/07 - 2007/03 Hokkaido University Graduate School of Veterinary Medicine

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Committee career (3)：

2012/10 - 現在日本神経化学会評議員
日本薬理学会評議員
日本獣医学会評議員

Association Membership(s) (3)：

日本神経化学会 , 日本薬理学会 , 日本獣医学会

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