Rchr
J-GLOBAL ID：200901065184059730   Update date: Feb. 16, 2024

Kusuhara Hiroyuki

クスハラ ヒロユキ | Kusuhara Hiroyuki
Affiliation and department：
The University of Tokyo Graduate School of Pharmaceutical Sciences, Department of Pharmaceutical Technology

About The University of Tokyo Graduate School of Pharmaceutical Sciences, Department of Pharmaceutical Technology


Job title： Professor
Homepage URL  (1)： http://www.f.u-tokyo.ac.jp/~molpk
Research field  (4)： Clinical pharmacy ,  Pharmaceuticals - chemistry and drug development ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (4)： Clinical Pharmacokinetics ,  トランスポーター ,  生物薬剤学 薬物動態 ,  Biopharmaceutics drug disposition transporter
Research theme for competitive and other funds  (37)：
  • 2021 - 2024 Development of a handy system for rapid drug monitoring from tiny amounts of blood
  • 2020 - 2023 Pharmacokinetic study on transporters in the xenobiotic detoxification among the liver, small intestine and kidney
  • 2020 - 2022 Development of an implantable sensory system that can approach safe and effective therapeutic interventions for neuropsychiatric disorders
  • 2019 - 2021 Development of lead optimization method using novel profile data analysis method
  • 2018 - 2021 Development of portable drug concentration measurement system for contributing to a personalized treatment.
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Papers (317)：
  • Yoshiki Hashimoto, Kazuya Maeda, Osamu Shimomura, Yoshihiro Miyazaki, Shinji Hashimoto, Akiko Moriyama, Tatsuya Oda, Hiroyuki Kusuhara. Evaluation of the risk of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors with cultured intestinal stem cells originated from crypts in humans and monkeys. Toxicology in vitro : an international journal published in association with BIBRA. 2023. 93. 105691-105691
  • Ryutaro Tamura, Yusuke Sabu, Tadahaya Mizuno, Seiya Mizuno, Satoshi Nakano, Mitsuyoshi Suzuki, Daiki Abukawa, Shunsaku Kaji, Yoshihiro Azuma, Ayano Inui, et al. Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis. Nature communications. 2023. 14. 1. 6763-6763
  • Hiromi Sato, Rika Marutani, Ryota Takaoka, Daniel Mori-Fegan, Xinying Wang, Kazuya Maeda, Hiroyuki Kusuhara, Hiroshi Suzuki, Hideki Yoshioka, Akihiro Hisaka. Model-based meta-analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism. CPT: pharmacometrics & systems pharmacology. 2023. 12. 8. 1132-1142
  • Takuro Saiki, Genki Ogata, Seishiro Sawamura, Kai Asai, Olga Razvina, Kota Watanabe, Rito Kato, Qi Zhang, Koei Akiyama, Sasya Madhurantakam, et al. A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip. Heliyon. 2023. e15963-e15963
  • Akihiko Goto, Syunsuke Yamamoto, Tomoko Igari, Shin-Ichi Matsumoto, Ikumi Chisaki, Koichi Iida, Miyu Nakayama, Akira Oda, Yuuichi Kakoi, Akio Uchida, et al. Quantitative Model Analysis and Simulation of Pharmacokinetics and Malat1 RNA Knockdown Effect After Systemic Administration of Cholesterol-conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice. The Journal of pharmacology and experimental therapeutics. 2022
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MISC (247)：
  • 出口清香, 出口清香, 津田真弘, 小杉香織, 前田和哉, 楠原洋之, 水口裕之, 水口裕之, 山下富義, 鳥澤勇介, et al. Generation and application of polydimethylsiloxane-based liver-on-a-chip for pharmacokinetic studies. 日本薬学会年会要旨集(Web). 2021. 141st
  • 古屋詩乃, 寺島花野, 前田和哉, 樋口裕一郎, 米田直央, 上原正太郎, 末水洋志, 楠原洋之. In vitro evaluation of biliary excretion of drugs with sandwich cultured hepatocytes originated from humanized liver mice. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
  • 道場一祥, 前田和哉, 楠原洋之. Investigation for the development of an in vitro system with differentiated cells derived from mouse intestinal stem cells to evaluate drug intestinal absorption. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
  • 齋木琢郎, 齋木琢郎, 緒方元気, 澤村晴志朗, ラズビナ オリガ, 渡邊航太, 加藤里都, 浅井開, 松本吉史, 森山雅人, et al. ダイヤモンド電極を用いた電気化学測定による薬物血中濃度の迅速測定. 日本生理学雑誌(Web). 2021. 83. 2
  • 道場一祥, 前田和哉, 楠原洋之. マウス消化管組織より単離したcrypt細胞由来分化細胞を用いた消化管における薬物輸送特性の基礎検討. HAB研究機構学術年会プログラム・要旨集. 2020. 27th
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Patents (1)：
  • 生物応答の解析方法、解析プログラム、及び解析装置
Books (2)：
  • 臨床薬物動態学(改訂第5版)
    2017
  • 分子薬物動態学
    南山堂 2008
Lectures and oral presentations  (51)：
  • Orthogonal Linear Separation Analysis (OLSA): an Approach to Decompose the Comlex Effects of a Drug to Understand its Pharamacological Properties
    (CBI学会2018年大会 2018)
  • Progress in development of endogenous biomarkers to assess transporter-mediated drug-drug interactions
    (2018 International Meeting on 22nd MDO and 33rd JSSX 2018)
  • Identification of N1-methyladenosine as a surrogate biomarker for drug interaction studies involving OCT2
    (2018 International Meeting on 22nd MDO and 33rd JSSX 2018)
  • Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs
    (2018 International Meeting on 22nd MDO and 33rd JSSX 2018)
  • Investigation of SLC35F2 drug transport function in mouse brain and primate BBB models
    (日本薬物動態学会 第33回年会 2018)
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Education (3)：
  • 1995 - 1997 University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1993 - 1995 University of Tokyo Faculty of Pharmaceutical Sciences
  • 1991 - 1993 University of Tokyo
Professional career (2)：
  • PhD (The University of Tokyo)
  • 薬学博士 (東京大学)
Work history (5)：
  • 2012/05 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences Professor
  • 2007/04 - 2012/04 The University of tokyo Graduate School of Pharmaceutical Sciences Associate Professor
  • 2005/04 - 2007/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Associate Professor
  • 2004/01 - 2005/03 The University of Tokyo Graduate School of Pharmaceutical Sciences Associate Professor
  • 1998/01 - 2003/12 The University of Tokyo Graduate School of Pharmaceutical Sciences Assistant Professor
Awards (10)：
  • 2018 - Japan Research Foundation for Clinical Pharmacology Japan Research Foundation for Clinical Pharmacology Award
  • 2016 - 臨床薬理学会 第27回臨床薬理研究振興財団賞学術奨励賞 トランスポーターの分子基盤に基づいた臨床薬物動態学研究
  • 2012 - Japan Research Foundation for Clinical Pharmacology Japan Research Foundation for Clinical Pharmacology Award
  • 2009 - ISSX Asian Pacific New Investigator Award
  • 2006 - 日本薬剤学会奨励賞
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Association Membership(s) (11)：
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS ,  日本薬剤学会 ,  日本薬学会 ,  日本薬物動態学会 ,  JAPANESE SOCIETY FOR ALTERNATIVES TO ANIMAL EXPERIMENTS ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  American Society for Clinical Pharmacology and Therapeutics ,  The American Society for Pharmacology and Experimental Therapeutics ,  International Society for the Study of Xenobiotics ,  レギュラトリーサイエンス学会
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