Shimizu Akira

2020 - 2023 内皮細胞のheterogeneityに着目した糸球体毛細血管網の維持機構の解明

2019 - 2023 自然・獲得免疫系を繋ぐ肺胞マクロファージの機序解明による同種・異種肺移植成績向上

2020 - 2023 The identification of the antigen and deposition proteins in glomerulonephritis and glomerular deposition diseases

2019 - 2022 Integrated omics analysis for drug discovery of intractable nephrotic syndrome

2019 - 2020 前臨床モデルでの移植片対宿主反応(LGVHR)に基づく革新的小腸移植免疫寛容誘導

2017 - 2020 Injuries of glomerular basement membrane in the progression of glomerular diseases

2016 - 2019 Effects of long-term hypergastrinemia on gastric mucosa

2016 - 2019 Modulation of inflammation and innate immune responses subsequent to endothelial cell damage in lung allo and xenotransplantation

2016 - 2019 Establish a treatment strategy to diabetic nephropathy using combined kidney and islets transplantation

2015 - 2018 Establishment of hydrogen sulfide therapy against renal ischemia-reperfusion injury using large animal to attempt to increase the donor organ pool

2015 - 2017 Basic research on technology development of tooth regeneration with regard to transcription factor Cebpb and Runx2

2014 - 2017 The pathological and immunological characteristics of grafts with long-term acceptance in rat liver transplantation

2014 - 2016 Establishment of novel lung preservation method in a stable unfrozen state under high pressurized condition

2013 - 2016 Effects of carbon monoxide inhalation on allograft survival of the lung or kidney from brain death donors in miniature swine.

2013 - 2016 Establishment of polychromatic FACS analysis for diagnosis of glomeluronephritis instead of pathology

2012 - 2015 Immunological network in ANCA associated glomerulonephritis

2011 - 2014 Attenuation of hyperacute dysfunction and coagulopathy in GalT-KO pulmonary xenotransplantation

2011 - 2014 Intestinal Transplantation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms, HVG and GVH Responses

2011 - 2013 Inflammation in rat liver transplantation model

2010 - 2012 Role of prevascularization of islets in the induction of tolerance of allogeneic islets in miniature swine

2010 - 2012 Attempt to induce tolerance of kidneys by pharmacologic rejuvenation of thymus in miniature swine

2008 - 2010 Xenotransplantation from GalT-KO miniture swine to baboon in tolerance induction protocol

2007 - 2010 GalT-knockout pig to monkey xenogeneic kidney and islet transplantation

2007 - 2008 Effect of HGF on chronic changes in renal allografts in partial ly inbred miniature swine

2006 - 2007 The mechanisms of graft failure in cardiac xenografts from α1,3-galactosyltransferase, gene-knockout (GalT-KO) pigs in babooons

1999 - 2002 同種腎移植における免疫寛容(トレランス)導入と移植臓器における免疫応答の特異性

1994 - 1995 増殖性糸球体腎炎の回復過程におけるアポトーシスの役割について

臓器移植後慢性拒絶反応の進展機序

糸球体腎炎における血管傷害,再生,新生

糸球体腎炎の進展機序

糸球体腎炎の進展の制御に関する研究

糸球体腎炎の進展機序に関する研究

血管傷害,血管新生・再生と糸球体腎炎に関する研究

the mechanisms of the progression of chronic rejection

vascular injury and angiogenesis in glomerulonephritis

the mechanisms of the progressine glomerulonephritis

Study on the treatment of progressine glomerulonephritis

Study on the mechanism of progressine glomerulonephritis

Study on vascular injury and angiogenesis in glomerulonephritis