Rchr
J-GLOBAL ID:200901065462360676   Update date: Jan. 28, 2023

Tadashi Kasahara

Tadashi Kasahara
Affiliation and department:
Research field  (2): Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (6): regulatory science ,  drug discovery ,  inflammasome ,  molecular signaling ,  immunopharmacology ,  cytokine・chemokine
Research theme for competitive and other funds  (2):
  • 2006 - 2011 (1) 接着班キナーゼFAKの抗アポトーシスならびに腫瘍転移における役割解析、(2) JAK2変異体の造血腫瘍とその機序の解析
  • 2006 - 2011 (1) Role of focal adhesion kinase in the anti-apoptotic signaling and the regulatory role in the metastasis of melanoma cells in vivo. (2) Role of JAK2 mutation in the tumorigenesis and the quest of
Papers (77):
  • Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, et al. Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease. Scientific reports. 2018. 8. 1. 7601
  • Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui-Kawanishi, Sachiko Watanabe, Hiroaki Kimura, Ryo Kamata, Koumei Shirasuna, Yutaro Koyama, Ayana Sato-Tomita, Takashi Matsuzaka, et al. Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018. 38. 4. 744-756
  • Ai Sadatomo, Yoshiyuki Inoue, Homare Ito, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Yoshiko Mizushina, Jun Nakamura, Ryo Kamata, Tadashi Kasahara, et al. Interaction of Neutrophils with Macrophages Promotes IL-1 beta Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury. JOURNAL OF IMMUNOLOGY. 2017. 199. 9. 3306-3315
  • Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Hiroaki Kimura, Ryo Kamata, Fumitake Usui-Kawanishi, Sachiko Watanabe, Satoshi Ohta, Megumi Funakoshi-Tago, Ken Yanagisawa, et al. ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages. JOURNAL OF IMMUNOLOGY. 2017. 199. 10. 3614-3622
  • Yuki Uchihara, Fumihito Ueda, Kenji Tago, Yosuke Nakazawa, Tomoyuki Ohe, Tadahiko Mashino, Shigenobu Yokota, Tadashi Kasahara, Hiroomi Tamura, Megumi Funakoshi-Tago. Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK. PLOS ONE. 2017. 12. 8. e0183003
more...
MISC (199):
Books (11):
  • 疾病と病態生理 改訂第4版
    南江堂 2016
  • アバス他 分子細胞免疫学 原著第7版(監訳 松島綱治、山田幸宏)
    エルぜビア・ジャパン 2014
  • スタンダード免疫学 第4版
    丸善 2013
  • 新しい薬学事典 笠原忠、木津純子、諏訪俊男編
    朝倉書店 2012
  • ヒューマニズム薬学入門
    培風館 2012 ISBN:9784563085513
more...
Lectures and oral presentations  (203):
  • LicochalconeAのTNFα誘導性NF-κBの活性化に及ぼす影響.
    (日本薬学会第128年会 2008)
  • LicochalconeDによるマスト細胞脱顆粒反応抑制機序の解析.
    (日本薬学会第128年会 2008)
  • 無脊椎動物由来糖脂質の合成研究(33)フトミミズ由来糖脂質の合成とその応用.
    (日本薬学会第128年会 2008)
  • 実務実習事前学習充実に向けた学生による実習評価.
    (医療薬学フォーラム2008 2008)
  • TNFシグナル系におけるTNF Receptor Associated Factor 6の役割.
    (日本薬学会第128年会 2008)
more...
Education (4):
  • - 1974 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1974 The University of Tokyo
  • - 1972 The University of Tokyo Faculty of Pharmaceutical Science
  • - 1972 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1):
  • 薬学博士 (東京大学)
Work history (7):
  • 2008 - 2009 :慶應義塾大学薬学部・教授(薬学部長・薬学研究科委員長)
  • 2009 - -:慶應義塾・常任理事(薬学部教授を兼担)
  • 2005 - 2008 :共立薬科大学・常務理事(教育担当)
  • 1995 - 2008 :共立薬科大学・教授
  • 1983 - 1995 :自治医科大学医学部・助教授
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