Rchr
J-GLOBAL ID：200901065462360676   Update date: Jan. 28, 2023

Tadashi Kasahara

Tadashi Kasahara
Affiliation and department：
International University of Health and Welfare Graduate School of Pharmacy

About International University of Health and Welfare Graduate School of Pharmacy


Research field  (2)： Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (6)： regulatory science ,  drug discovery ,  inflammasome ,  molecular signaling ,  immunopharmacology ,  cytokine・chemokine
Research theme for competitive and other funds  (2)：
  • 2006 - 2011 (1) 接着班キナーゼFAKの抗アポトーシスならびに腫瘍転移における役割解析、(2) JAK2変異体の造血腫瘍とその機序の解析
  • 2006 - 2011 (1) Role of focal adhesion kinase in the anti-apoptotic signaling and the regulatory role in the metastasis of melanoma cells in vivo. (2) Role of JAK2 mutation in the tumorigenesis and the quest of
Papers (77)：
  • Nakamura J, Watanabe S, Kimura H, Kobayashi M, Karasawa T, Kamata R, Usui-Kawanishi F, Sadatomo A, Mizukami H, Nagi-Miura N, et al. Adeno-associated Virus Vector-mediated Interleukin-10 Induction Prevents Vascular Inflammation in a Murine Model of Kawasaki Disease. Scientific reports. 2018. 8. 1. 7601
  • Tadayoshi Karasawa, Akira Kawashima, Fumitake Usui-Kawanishi, Sachiko Watanabe, Hiroaki Kimura, Ryo Kamata, Koumei Shirasuna, Yutaro Koyama, Ayana Sato-Tomita, Takashi Matsuzaka, et al. Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018. 38. 4. 744-756
  • Ai Sadatomo, Yoshiyuki Inoue, Homare Ito, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Yoshiko Mizushina, Jun Nakamura, Ryo Kamata, Tadashi Kasahara, et al. Interaction of Neutrophils with Macrophages Promotes IL-1 beta Maturation and Contributes to Hepatic Ischemia-Reperfusion Injury. JOURNAL OF IMMUNOLOGY. 2017. 199. 9. 3306-3315
  • Akira Kawashima, Tadayoshi Karasawa, Kenji Tago, Hiroaki Kimura, Ryo Kamata, Fumitake Usui-Kawanishi, Sachiko Watanabe, Satoshi Ohta, Megumi Funakoshi-Tago, Ken Yanagisawa, et al. ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages. JOURNAL OF IMMUNOLOGY. 2017. 199. 10. 3614-3622
  • Yuki Uchihara, Fumihito Ueda, Kenji Tago, Yosuke Nakazawa, Tomoyuki Ohe, Tadahiko Mashino, Shigenobu Yokota, Tadashi Kasahara, Hiroomi Tamura, Megumi Funakoshi-Tago. Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK. PLOS ONE. 2017. 12. 8. e0183003
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MISC (199)：
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Books (11)：
  • 疾病と病態生理 改訂第4版
    南江堂 2016
  • アバス他 分子細胞免疫学 原著第7版(監訳 松島綱治、山田幸宏)
    エルぜビア・ジャパン 2014
  • スタンダード免疫学 第4版
    丸善 2013
  • 新しい薬学事典 笠原忠、木津純子、諏訪俊男編
    朝倉書店 2012
  • ヒューマニズム薬学入門
    培風館 2012 ISBN:9784563085513
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Lectures and oral presentations  (203)：
  • LicochalconeAのTNFα誘導性NF-κBの活性化に及ぼす影響.
    (日本薬学会第128年会 2008)
  • LicochalconeDによるマスト細胞脱顆粒反応抑制機序の解析.
    (日本薬学会第128年会 2008)
  • 無脊椎動物由来糖脂質の合成研究(33)フトミミズ由来糖脂質の合成とその応用.
    (日本薬学会第128年会 2008)
  • 実務実習事前学習充実に向けた学生による実習評価.
    (医療薬学フォーラム2008 2008)
  • TNFシグナル系におけるTNF Receptor Associated Factor 6の役割.
    (日本薬学会第128年会 2008)
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Education (4)：
  • - 1974 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
  • - 1974 The University of Tokyo
  • - 1972 The University of Tokyo Faculty of Pharmaceutical Science
  • - 1972 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 薬学博士 (東京大学)
Work history (7)：
  • 2008 - 2009 :慶應義塾大学薬学部・教授(薬学部長・薬学研究科委員長)
  • 2009 - -:慶應義塾・常任理事(薬学部教授を兼担)
  • 2005 - 2008 :共立薬科大学・常務理事(教育担当)
  • 1995 - 2008 :共立薬科大学・教授
  • 1983 - 1995 :自治医科大学医学部・助教授
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