Rchr
J-GLOBAL ID：200901065473744417
Update date: Nov. 06, 2024
Mimori Koshi
ミモリ コオシ | Mimori Koshi
Affiliation and department：
Job title：
Professor
Research field (1)：
General surgery, pediatric surgery
Research keywords (2)：
腫瘍外科学
, Surgical Oncology
Research theme for competitive and other funds (70)：
- 2024 - 2027 遺伝性胃癌臨床検体を用いた上部胃癌発癌メカニズムの解明と革新的治療法の確立
- 2023 - 2026 膵がん微小環境を構築する細胞社会において免疫寛容に寄与するがん代謝機構の解明
- 2023 - 2026 転写産物のロングリード・シーケンスによる食道癌化学放射線療法抵抗性獲得機構の解明
- 2022 - 2025 固形癌における抗腫瘍薬の薬剤耐性を改善するグルタミン代謝抑制化合物の開発
- 2022 - 2025 タイプ別胃癌の誘因と発癌・進展における分子機序および免疫応答メカニズムの解明
- 2022 - 2025 時・空間的シングルセル解析による膵がん細胞の悪性度獲得機構の解明と治療標的の同定
- 2022 - 2025 肝内胆管癌多層オミックス解析と機械学習によるリポジショニング薬の同定
- 2022 - 2025 肝がんの分化規定遺伝子の同定と革新的治療法の開発
- 2022 - 2025 空間的遺伝子発現解析を用いた食道癌CRT抵抗性に関わる免疫微小環境の検討
- 2022 - 2025 空間的シングルセル解析による大腸がん転移巣を形成するがん微小環境の解明
- 2022 - 2025 大腸がん細胞との共局在により悪性度と免疫寛容を獲得するがん微小環境の解明
- 2021 - 2024 非小細胞肺がんにおいてGefitinib耐性克服をめざした新規化合物について
- 2021 - 2024 大腸がんctDNAの術後早期再発診断システム開発と再発への進化系統樹の臨床的意義
- 2021 - 2024 Development of the novel therapy for NAFLD by Engineering Fatty Liver from iPS cells
- 2020 - 2023 多領域検体・多層オミックス解析で多様性を凌駕する真の肝内胆管がん治療標的の同定
- 2020 - 2023 Genetic assessments to detect patients requiring prophylactic total pancreatectomy for the prevention of pancreatic cancer.
- 2020 - 2022 IPMN as a risk factor for pancreatic ductal adenocarcinoma; challenge for early diagnosis of pancreatic cancer by the assessment of clonal expansion
- 2020 - 2022 Multi-regional analysis and the simulation of evolution elucidate the intra-tumor diversity of colorectal cancer.
- 2019 - 2022 Understanding of the genomic evolution and cancer microenvironment to identify a susceptible marker to immune therapy for IHCC.
- 2019 - 2022 Aberrant Regulation of Protein Translation Start Sites in Colorectal Cancer Identified by Genome Evolution Models
- 2019 - 2022 Clarification of the bona-fide evolution from early to advanced CRC to establish the eradication methods.
- 2020 - 2021 ctDNAメチル化検出を実装する新たなアプローチによる大腸癌再発早期診断法の確立
- 2018 - 2021 Epigenome and transcriptome analysis of hepatocellular carcinoma after eradication of hepatitis C virus
- 2018 - 2021 Genetic background factors and local cancer microenvironmental factors determining tumor immune response in colorectal cancer
- 2017 - 2020 Prognostic impact of immune-related gene expression in preoperative peripheral blood from gastric cancer patients
- 2015 - 2020 Achievement of highly accurate diagnosis of early pancreatic cancer in Japanese patients through a comprehensive/integrated approach
- 2017 - 2019 Identification of microRNA as a serum biomarker for regulatory T cell in CRC cases.
- 2016 - 2019 Identification of novel therapeutic target genes based on genomic progression model of colorectal cancer
- 2016 - 2019 The development of genomically stability and chromosomal instability and the molecular mechanism of peritoneal metastases for gastric cancer
- 2016 - 2019 Analysis of genomic and epigenomic intratumoral heterogeneity reveals mechanisms of resistance to chemoradiotherapy in esophageal cancer
- 2016 - 2019 TCR repertoire analysis in esophageal cancer
- 2016 - 2018 Systematic and integrative analysis of the occurrence of genetic heterogeneity in CRC
- 2016 - 2018 Innovational diagnostic technique of recurrence by using circulating tumor DNA in CRC patients
- 2015 - 2018 Development of noninvasive and accurate theranostic nanodevices and analysis of their renal excretion
- 2015 - 2018 Comprehensive epigenome-transcriptome analysis of hepatocellular carcinoma after eradication of hepatitis C
- 2015 - 2018 The development of detection of cancer cells with gGlu-HMRG and clinical application
- 2015 - 2018 Spacial and temporal comics analysis dissolve the evolution and heterogeneity in ESCC.
- 2014 - 2018 Analysis of micro RNA as new treatment target of radiation therapy for esophageal cancer on In vivo and clinical cases.
- 2014 - 2017 New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics
- 2014 - 2016 Identification of a molecular target of colorectal cancers with associated copy number aberrations between two different chromosomal loci.
- 2013 - 2016 Novel therapeutic development with the target of cancer cell eradication against cancer stem cells
- 2013 - 2015 Identification of novel inducing factors pancreatic beta cells by iPS modified technology
- 2011 - 2015 Analysis of microRNA and Gene regulating radiosensitivity improving of radiotheraphy for esophageal cancer
- 2009 - 2013 マイクロRNAを介した消化器癌転移カスケードの解明
- 2010 - 2012 Identification of microRNA and non-coding RNA regulating the oncogenesis and the progression of colorectal cancers
- 2011 - 2011 スーパーコンピューターを用いた大腸発癌関連全因子の統合的解析による発癌機構の解明
- 2009 - 2011 Evaluation of the anti-tumor effect of microRNA on cancer metastasis under the general anesthesia
- 2009 - 2010 癌幹細胞の増幅と創薬応用を目指す未来型の探索研究
- 2008 - 2010 A role of Tumor Suppressor Fhit Product in Cell Death, Survival and Carcinogenesis
- 2008 - 2010 Genetic analysis of cancer stems cells in the carcinogenesis and the intractability of treatment of cancer.
- 2009 - 2009 大規模症例における消化器癌転移メカニズムの網羅的・統合的解析
- 2008 - 2008 大腸癌における肝転移を規定するmicroRNAの同定と機能解析
- 2007 - 2008 Identification and functional analysis of cancer stem cells isolated from circulating tumor cells in gastroenterological cancerpatients
- 2007 - 2008 Clarification of the mechanism giving rise to metastasis by the analysis of gene expression in bone marrow and peripheral blood in cancer patients
- 2005 - 2008 Study of molecular-genetics, and molecular epidemiology for developing treatment of esophageal cancer
- 2006 - 2007 Identification of the methylation related genes in gastric cancer
- 2006 - 2007 Molecular Genetics of the Heterogeneiety of Gastrointestinal Cancer in association of cancer stem cells.
- 2006 - 2007 慢性炎症により生じる消化器癌幹細胞を標的とした治療法の開発
- 2004 - 2005 悪臭を伴う進行皮膚露出乳癌に対する消臭および抗腫瘍治療の開発
- 2004 - 2005 Molecular Genetics of the Heterogeneiety of the Tumor Perturbing Cacer Treatment
- 2003 - 2004 Intratumoral injection of dendritic cells after treatment of anticancer drugs induces tumor-specific antitumor effect in vivo
- 2003 - 2004 Establishment of melecular-based diagnositics for esophageal cancer
- 2003 - 2004 FHIT Suppresses Prostaglandin E_2 in the Carcinogenic Activity by Inflammation in Colorectal Cancer.
- 2002 - 2003 Clinical significance of p27 regulator skastrointestinal tract and breast
- 2002 - 2003 Analysis on the genes producing the diversity of the cancers, resulting the difficulties of their treatment.
- 2001 - 2002 Functional analysis of the cancer suppressor gene FHIT and application for the gene therapy against cancer
- 胃癌・乳癌における微量癌細胞の検出
- 癌におけるFHIT遺伝子不活化機構の解明
- Identification of the occult cancer cell in gastric cancer and breast cancer
- Analysis of the mechanism of the FHIT gene inactivation.
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Papers (442)：
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Takafumi Nakano, Seiichiro Takao, Katsushi Dairaku, Naoki Uno, Siew-Kee Amanda Low, Masahiro Hashimoto, Yasuo Tsuda, Yuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, et al. Implementable assay for monitoring minimum residual disease after radical treatment for colorectal cancer. Cancer science. 2024
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Hirofumi Ohmura, Taro Tobo, Yuki Ando, Takaaki Masuda, Koshi Mimori, Koichi Akashi, Eishi Baba. Case report: A rare case of triple negative breast cancer with development of acute pancreatitis due to dexamethasone during adjuvant chemotherapy. Frontiers in oncology. 2024. 14. 1340419-1340419
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Keisuke Kosai, Takaaki Masuda, Akihiro Kitagawa, Taro Tobo, Yuya Ono, Yuki Ando, Junichi Takahashi, Naoki Haratake, Mikihiro Kohno, Tomoyoshi Takenaka, et al. ASO Visual Abstract: Transducin Beta-like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma. Annals of Surgical Oncology. 2023
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Yuta Kobayashi, Atsushi Niida, Satoshi Nagayama, Koichi Saeki, Hiroshi Haeno, Kazuki K Takahashi, Shuto Hayashi, Yuki Ozato, Hideyuki Saito, Takanori Hasegawa, et al. Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers. British journal of cancer. 2023
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Keisuke Kosai, Takaaki Masuda, Akihiro Kitagawa, Taro Tobo, Yuya Ono, Yuki Ando, Junichi Takahashi, Naoki Haratake, Mikihiro Kohno, Tomoyoshi Takenaka, et al. Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma. Annals of Surgical Oncology. 2023
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MISC (362)：
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Qingjiang Hu, Koshi Mimori. ASO Author Reflections: ARL4C and Peritoneal Dissemination in Gastric Cancer. Annals of Surgical Oncology. 2019. 26. 547
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Masamitsu Konno, Jun Koseki, Ayumu Asai, Akira Yamagata, Teppei Shimamura, Daisuke Motooka, Daisuke Okuzaki, Koichi Kawamoto, Tsunekazu Mizushima, Hidetoshi Eguchi, et al. Distinct methylation levels of mature microRNAs in gastrointestinal cancers. Nature communications. 2019. 10. 1. 3888-3888
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Junko Mukohyama, Yohei Shimono, Piero Dalerba, Taichi Isobe, Qingjiang Hu, Debashis Sahoo, Naoki Shibuya, Hironobu Minami, Koshi Mimori, Yoshihiro Kakeji, et al. Epigenetic regulation of colorectal cancer stem cells by the miR-221/QKI5 axis. CANCER RESEARCH. 2018. 78. 13
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The molecular mechanism of peritoneal dissemination. 2017. 79. 10. 901-906
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Daisuke Kuroda, Junji Kurashige, Hiroshi Sawayama, Masaaki Iwatsuki, Tomoyuki Uchihara, Tasuku Toihata, Eri Oda, Taisuke Yagi, Tsugio Eto, Keisuke Miyake, et al. Significance of SERPINE2 expression in peritoneal metastasis in gastric carcinoma. CANCER RESEARCH. 2017. 77
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Works (1)：
-
Identification of ITC in bone marrow and peripheral blood in gastric and breast cancer cases.
2005 -
Education (2)：
- - 1991 Oita Medical University
- - 1991 Oita Medical University Faculty of Medicine
Professional career (1)：
- Medical Doctor (Kyushu University)
Committee career (2)：
- 2006 - Sosiety of Surgical Oncology Corresponding member
- 日本消化器癌発生学会 評議員
Awards (3)：
- 2004 - 平成16年度 日本癌学会 研究奨励賞受賞
- 2004 - 平成16年度 日本がん転移学会 研究奨励賞受賞
- 2004 - 平成16年度 膵臓病財団研究奨励賞
Association Membership(s) (9)：
Sosiety of Surgical Oncology
, 日本がん転移学会
, 日本食道学会
, 大腸肛門病学会
, 日本消化器癌発生学会
, 日本癌学会
, 日本消化器外科学会
, 日本癌治療学会
, 日本外科学会
