Toru Hosoi

ホソイトオル | Toru Hosoi

Affiliation and department：
Job title： Professor

Research field (5)： Pathobiochemistry , Nutrition and health science , Physiology , Neuroscience - general , Pharmacology

Research keywords (16)：視床下部 , LPS , 炎症性サイトカイン , ALDH , 膵臓 , グリア細胞 , 神経細胞 , レプチン , BRET , 糖尿病 , 創薬 , オートファジー , 老化 , 小胞体ストレス , 肥満 , 神経変性疾患

Research theme for competitive and other funds (16)：

2022 - 2025 Do Food Additives Cause Obesity?-Elucidation of the mechanism of action on leptin receptor signaling-
2021 - 2024 マスト細胞機能における小胞体ストレスの役割解明と新規アレルギー治療標的の探索
2019 - 2023 Elucidation of the strategy towards the healthy life expectancy stretching by the use of big data
2019 - 2022 生体内因子・小胞体ストレスによる肥満・生活習慣病形成機構の分子機序解明と創薬
2018 - 2021 Prediction of disease progression by analyzing endoplasmic reticulum stress sensor system

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Papers (108)：

Toru Hosoi, Kyosuke Yazawa, Michihiro Imada, Akari Tawara, Chihiro Tohda, Yasuyuki Nomura, Koichiro Ozawa. Alkannin Attenuates AmyloidβAggregation and Alzheimer’s Disease Pathology. Molecular Pharmacology. 2023. 103. 5. 266-273
Tadashi Nakagawa, Satoko Hattori, Toru Hosoi, Keiko Nakayama. Neurobehavioral characteristics of mice with SETD5 mutations as models of IDD23 and KBG syndromes. Frontiers in Genetics. 2023. 13
Arini Isnani Preninka, Karen Kuriya, Kyosuke Yazawa, Michiko Yoshii, Yuhki Yanase, Ralf Jockers, Julie Dam, Toru Hosoi, Koichiro Ozawa. Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress. PLOS ONE. 2022. 17. 12. e0278965-e0278965
Keigo Tanaka, Kohei Kuramoto, Tadashi Nakagawa, Yasuyuki Nomura, Koichiro Ozawa, Toru Hosoi. COOH-terminal fragment of APP interacts with p62, forms an aggregate, and induces autophagic degradation in Alzheimer’s cell model. American Journal of Physiology-Cell Physiology. 2022. 323. 6. C1633-C1641
Yosuke Yamawaki, Hitomi Kimura, Susumu Nagata, Koichiro Ozawa, Toru Hosoi. Peripheral Immune Activation in Mice Elicits Unfolded Protein Responses Independent on MyD88 Pathway in the Liver but not the Hypothalamus and Hippocampus. Frontiers in Physiology. 2022. 13

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MISC (20)：

細井徹, 俵明里, 今田理裕, 東田千尋, 金子雅幸, 藤田有紀, 奥田充顕, 杉本八郎, 小澤光一郎, 西昭徳, et al. 生薬alkanninとshikoninのAβとタウタンパク凝集阻害と神経細胞死阻害活性抗アルツハイマー病薬創製に向けて. 日本薬学会年会要旨集. 2017. 137年会. 3. 108-108
Toru Hosoi, Rie Yamaguchi, Kikuko Noji, Takaaki Kayano, Kohei Mori, Koichiro Ozawa. Flurbiprofen ameliorated endoplasmic reticulum stress by interacting with aldehyde dehydrogenase. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 200P-200P
Yaichiro Kotake, Midori Isomura, Kyoichi Masuda, Masatsugu Miyara, Katsuhiro Okuda, Shigeyoshi Samizo, Seigo Sanoh, Toru Hosoi, Koichiro Ozawa, Shigeru Ohta. Tributyltin-induced endoplasmic reticulum stress and its mechanism. TOXICOLOGY LETTERS. 2013. 221. S173-S173
Rie Yamaguchi, Toru Hosoi, Sachiko Baba, Keisuke Toyoda, Kikuko Noji, Koichiro Ozawa. Exploration of a new class of anti-obesity agents which targets ER stress. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 226P-226P
Keisuke Toyoda, Toru Hosoi, Koichiro Ozawa. A novel compound ameliorating leptin resistance induced by endoplasmic reticulum stress in obesity. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 226P-226P

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Professional career (1)：

Doctor of Philosophy in Pharmaceutical Science (HOKKAIDO UNIVERSITY)

Committee career (1)：

2010 - 現在 Frontiers in Cellular Endocrinology (Associate Editor)

Awards (5)：

2016 - 平成28年度広島大学薬学教育研究奨励賞
2015 - 広島大学Distinguished Researcher(DR: 特に優れた研究を行う若手教員)認定
2014 - 平成26年度広島大学病院論文賞ハイインパクト賞
2011 - 日本脳科学会奨励賞
2010 - 平成23年度日本薬学会奨励賞

Association Membership(s) (5)：

THE JAPANESE PHARMACOLOGICAL SOCIETY , The Japanese Biochemical Society , The Japanese Society for Neurochemistry , The Pharmaceutical Society of Japan (PSJ) , 米国生理学会

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