Rchr
J-GLOBAL ID:200901065842977587
Update date: Aug. 04, 2024
Harada Shin'ichi
Harada Shin'ichi
Affiliation and department:
Job title:
Associate Professor
Homepage URL (1):
http://web.kanazawa-u.ac.jp/~med59/
Research field (1):
Medical biochemistry
Research keywords (5):
神経変性
, 神経伝達
, Neuroprotection
, Neurodegeneration
, Neurotaransmission
Research theme for competitive and other funds (26):
- 2021 - 2024 免疫正常マウスを用いた線維性胃癌腹膜播種モデルにおける免疫抑制性微小環境の改変
- 2019 - 2023 胃癌腹膜播種における脂質代謝変容の解明と標的治療への応用
- 2019 - 2022 Mechanisms of epigenetic regulation of glod-4/GLO1 gene in C. elegans
- 2016 - 2019 Functional analysis of IL-17 producing cells in peritoneal metastasis of gastric cancer and examination of its tumorigenecity
- 2019 - 2019 体液診断における進行性胃癌細胞特異的バイオマーカーmiRNAの探索と簡易検査法の構築
- 2014 - 2017 Molecular basis of lifespan and aging by exposing LED light in C. elegans
- 2013 - 2016 The function of intraperitoneal macrophage and its tumorigenesis in gastic cancer with peritoneal metastasis
- 2010 - 2012 Human Peritoneal Mesothelial Cell play important roles in the development of peritoneal metastasis by its EMT change
- 2010 - 2012 Development of low-invasive/non-destructive measurements by using needle-type magnetic resistance probe with micro driving mechanism
- 2007 - 2008 Development of molecular targeted therapy via TGFb and angiotensin system for peritoneal dissemination of gastric cancer
- 2005 - 2006 The development of early diagnostic marker for peritoneal metastasis, and the management of tumor fibrosis through angiotensin II type I (AT1) receptor in gastric cancer.
- 2005 - 2006 Study of extremely low frequency magnetic fields-responding mechanism in neuron
- 2006 - AGE受容体の選択的スプライシングによる制御機構
- 2006 - Regulation of alternative splicing of receptor for advanced glycation endproducts
- 2002 - 2003 Exocyst複合体を介した新たなシナプス伝達制御機構の解明
- 2002 - 神経伝達の分子機構に関する研究
- 2002 - Molecular mechanisms of synaptic transmission
- 2000 - 2001 sec遺伝子による新たなシナプス伝達制御機構の解明
- 2001 - 低周波交流磁界の生物的影響に関する研究
- 2001 - Research on Biological Effects of Extremely Low Frequency High Magnetic Fields
- 1999 - 1999 生体内特定活動ニューロンをモニターするベクター系の開発
- 1998 - 1999 Influences of extremely low-frequency alternate-current high magnetic fields on gene replication, repair and expression
- 1998 - 1999 シナプス終末で働く遺伝子群の共役的発言制御機構の解明
- 1997 - 1998 低周波交番・回転高磁界における遺伝子および生化学反応への影響評価の研究
- 1996 - 1998 Cooperative Research toward Antisense Diagnosis and Therapy
- 1997 - 1997 Antisense Display-新しい機能性遺伝子スクリーニング法開発の試み
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Papers (53):
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Tatsuya Aoki, Jun Kinoshita, Seiichi Munesue, Toshihide Hamabe-Horiike, Takahisa Yamaguchi, Yusuke Nakamura, Koichi Okamoto, Hideki Moriyama, Keishi Nakamura, Shinichi Harada, et al. ASO Visual Abstract: Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake. Annals of surgical oncology. 2023
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Tatsuya Aoki, Jun Kinoshita, Seiichi Munesue, Toshihide Hamabe-Horiike, Takahisa Yamaguchi, Yusuke Nakamura, Koichi Okamoto, Hideki Moriyama, Keishi Nakamura, Shinichi Harada, et al. Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake. Annals of surgical oncology. 2022
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Toshihide Hamabe-Horiike, Shin-Ichi Harada, Kyoko Yoshida, Jun Kinoshita, Takahisa Yamaguchi, Sachio Fushida. Adipocytes contribute to tumor progression and invasion of peritoneal metastasis by interacting with gastric cancer cells as cancer associated fibroblasts. Cancer reports (Hoboken, N.J.). 2022. e1647
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Yusuke Nakamura, Jun Kinoshita, Takahisa Yamaguchi, Tatsuya Aoki, Hiroto Saito, Toshihide Hamabe-Horiike, Shinichi Harada, Sachiyo Nomura, Noriyuki Inaki, Sachio Fushida. Crosstalk between cancer-associated fibroblasts and immune cells in peritoneal metastasis: inhibition in the migration of M2 macrophages and mast cells by Tranilast. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2022
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Toshihide Hamabe-Horiike, Kanji Kawasaki, Masataka Sakashita, Chihiro Ishizu, Tomokazu Yoshizaki, Shin-Ichi Harada, Keiko Ogawa-Ochiai, Yohei Shinmyo, Hiroshi Kawasaki. Glial cell type-specific gene expression in the mouse cerebrum using the piggyBac system and in utero electroporation. Scientific Reports. 2021. 11. 1. 4864
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MISC (69):
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所智和, 牧野勇, 岡崎充善, 山口貴久, 大畠慶直, 中沼伸一, 林泰寛, 宮下知治, 田島秀浩, 高村博之, et al. 急性膵炎重症化の病態解明:好中球細胞外トラップと血管外血小板凝集. すい臓. 2017. 32. 3. 339
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J. Kinoshita, S. Fushida, S. Harada, K. Oyama, T. Yamaguchi, A. Hirose, K. Okamoto, K. Nakamura, T. Miyashita, H. Tajima, et al. Adipose tissue-derived stem cells provide an advantageous tumor microenvironment in gastric cancer. ANNALS OF ONCOLOGY. 2016. 27
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渡邉 利史, 田島 秀浩, 林 泰寛, 中川原 寿俊, 大西 一朗, 高村 博之, 二宮 致, 北川 裕久, 伏田 幸夫, 谷 卓, et al. ヒストン脱アセチル化酵素阻害薬による肝線維化抑制作用について. 肝臓. 2011. 52. Suppl.1. A362-A362
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Yasumichi Yagi, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Hideto Fujita, Itasu Ninomiya, Takashi Fujimura, Masato Kayahara, et al. Biodistribution of humanized anti-VEGF monoclonal antibody/bevacizumab on peritoneal metastatic models with subcutaneous xenograft of gastric cancer in mice. Current Microbiology. 2010. 61. 745-753
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Jun Kinoshita, Sachio Fushida, Shinichi Harada, Yasumichi Yagi, Hideto Fujita, Shinichi Kinami, Itasu Ninomiya, Takashi Fujimura, Masato Kayahara, Masakazu Yashiro, et al. Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-kappa B and survivin. INTERNATIONAL JOURNAL OF ONCOLOGY. 2009. 34. 6. 1573-1582
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Works (2):
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低侵襲診断チップシステム開発
2003 -
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Development of low invasive diagnostic bio-chips
2003 -
Education (4):
- - 1995 Kanazawa University
- - 1995 Kanazawa University Graduate School, Division of Medicine
- - 1991 Toyohashi University of Technology
- - 1991 Toyohashi University of Technology
Professional career (2):
- 博士(医学) (金沢大学)
- 修士(工学) (豊橋技術科学大学)
Awards (2):
- 1999 - 第14回基礎医学医療研究助成金
- 1999 - 第17回日本生化学会北陸支部奨励賞(米山賞)
Association Membership(s) (2):
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