Rchr
J-GLOBAL ID：200901065888313624   Update date: Oct. 10, 2024

Chayama Kazuaki

チャヤマ カズアキ | Chayama Kazuaki
Affiliation and department：
Public Interest Incorporated Foundation Hiroshima Institute of Life Sciences

About Public Interest Incorporated Foundation Hiroshima Institute of Life Sciences


Research field  (1)： Gastroenterology
Research keywords  (10)： hepatocellular carcinoma ,  hepatitis ,  whole genome sequencing ,  Hepatitis-C ,  whole genome analysisi ,  deep sequence ,  driver mutation ,  liver cirrhosis ,  epigenetics ,  nucleotide sequence|Hepatitis-B
Research theme for competitive and other funds  (42)：
  • 2021 - 2024 ヒト肝細胞キメラマウスモデルとヒト組織学的進展例材料を用いたNASHの研究
  • 2021 - 2023 脂肪肝炎を背景とする代謝関連肝がん発生の病態解明に関する研究
  • 2017 - 2019 2本鎖DNAを使用せず高度の安全性を保証する遺伝子治療の開発
  • 2017 - 2018 高効率感染細胞系と長期持続肝炎マウスモデルを用いたHBV排除への創薬研究
  • 2017 - 2018 C型肝炎ウイルス排除後の病態、生命予後、QOLに関する包括的研究
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Papers (2,287)：
  • Sarah Duehren, Takuro Uchida, Masataka Tsuge, Nobuhiko Hiraga, Susan L Uprichard, Ohad Etzion, Jeffrey Glenn, Christopher Koh, Theo Heller, Scott J Cotler, et al. Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice. Virus research. 2024. 349. 199451-199451
  • Xian-Yang Qin, Yohei Shirakami, Masao Honda, Shiou-Hwei Yeh, Kazushi Numata, Ya-Yun Lai, Chiao-Ling Li, Feifei Wei, Yali Xu, Kenji Imai, et al. Serum MYCN as a predictive biomarker of prognosis and therapeutic response in the prevention of hepatocellular carcinoma recurrence. International journal of cancer. 2024. 155. 3. 582-594
  • Hiromi Abe-Chayama, Takakazu Kawase, Tatsuo Ichinohe, Yuji Ishida, Chise Tateno, Makoto Hijikata, Kazuaki Chayama. Hepatitis B virus-specific human stem cell memory T cells differentiate into cytotoxic T cells and eradicate HBV-infected hepatocytes in mice. FEBS letters. 2024. 598. 11. 1354-1365
  • Takuma Nakatsuka, Ryosuke Tateishi, Masaya Sato, Natsuka Hashizume, Ami Kamada, Hiroki Nakano, Yoshinori Kabeya, Sho Yonezawa, Rie Irie, Hanako Tsujikawa, et al. Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease. Hepatology (Baltimore, Md.). 2024
  • Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Aya Mizobuchi, Shunsuke Tanigawa, Farina Mohamad Yusoff, Yukiko Nakano, et al. Upstroke time is a more useful marker of atherosclerosis than percentage of mean arterial pressure for detecting coronary artery disease in subjects with a normal ankle-brachial index. Hypertension research : official journal of the Japanese Society of Hypertension. 2024
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MISC (967)：
  • Takuma Nakatsuka, Ryosuke Tateishi, Hirokazu Takahashi, Yuichiro Eguchi, Eisuke Murakami, Kazuaki Chayama, Takeshi Okanoue, Kazuhiko Koike. LIVER STIFFNESS BY TRANSIENT ELASTOGRAPHY TO PREDICT CLINICAL EVENTS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE: A MULTICENTER STUDY OF 995 BIOPSY-PROVEN CASES. HEPATOLOGY. 2022. 76. S81-S82
  • Katsuaki Inagaki, Yasuhiko Kitadai, Toshikatsu Naito, Hidehiko Takigawa, Ryo Yuge, Shinji Tanaka, Kazuaki Chayama. Analysis of the distribution and phenotype of infiltrating macrophages in early-stage colorectal neoplasia. CANCER SCIENCE. 2021. 112. 796-796
  • Toshikatsu Naito, Yasuhiko Kitadai, Hidehiko Takigawa, Ryo Yuge, Toshio Kuwai, Wataru Yasui, Shinji Tanaka, Kazuaki Chayama. Expression of SPARC is associated with poor prognosis in human colorectal cancer. CANCER SCIENCE. 2021. 112. 688-688
  • Ryo Yuge, Naoki Yorita, Hidehiko Takigawa, Toshikatsu Naito, Katsuaki Inagaki, Hiroki Kadota, Yasuhiko Kitadai, Shinji Tanaka, Kazuaki Chayama. The effect of combination therapy of stromal reaction inhibitor and immune checkpoint inhibitor on colorectal cancer. CANCER SCIENCE. 2021. 112. 741-741
  • Daiki Miki, Hiroshi Aikata, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Masataka Tsuge, Kazuaki Chayama. Genetic polymorphism in PNPLA3 is associated with hepatocellular carcinoma after hepatitis C virus eradication. CANCER SCIENCE. 2021. 112. 486-486
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Patents (10)：
  • 肝細胞癌への進展予測マーカー
  • B型肝炎発症ヒト肝細胞キメラモデル動物の作製方法
  • HCVの治療剤又は予防剤
  • インターフェロン療法の効果予測用マーカー
  • HCV核酸配列
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Books (498)：
  • Hepatitis B Virus and Liver Disease
    Springer Singapore 2021
  • H.pylori未感染胃粘膜に生じる印環細胞癌
    消化器内視鏡 2020
  • 腫瘍性病変
    診断と治療 2020
  • 「大腸ESD/EMRガイドライン」の当科における運用
    臨牀消化器内科 2020
  • 特集 B型肝炎患者の長期予後とC型肝炎の残された課題
    消化器内科 2020
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Lectures and oral presentations  (907)：
  • 肝硬変診療の課題
    (日本消化器関連学会機構(JDDW)2019 2019)
  • ウイルス性肝炎研究の進歩と今後の課題
    (第23回日本肝臓学会大会 2019)
  • ウイルス肝炎研究の進歩と今後の課題
    (第23回日本肝臓学会大会 2019)
  • 最新のC型肝炎、肝硬変の治療
    (第33回日本臨床内科医学会 2019)
  • HCV治療の今後の展望-ウイルス性肝炎撲滅を目指した最新治療
    (第20回日本肝がん分子標的治療研究会 2019)
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Works (1)：
  • 広島大学ラグビー部顧問,第32回中国四国医科学生ラグビーフットボール大会 広島大学優勝
Education (1)：
  • 1974 - 1981 Hiroshima University Faculty of Medicine
Professional career (1)：
  • Doctor of Philosophy in Medical Sciences (The University of Tokyo)
Work history (11)：
  • 2002/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical Sciences Professor
  • 2002/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical Sciences Professor
  • 2015/04/01 - 2016/03/31 Hiroshima University Special Assistant to the President
  • 2012/04/01 - 2015/03/31 Hiroshima University Executive and Vice President
  • 2011/04/01 - 2015/03/31 Hiroshima University Hospital Director
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Awards (18)：
  • 2019/05/09 - 一般財団法人日本消化器病学会理事長 第3回 日本消化器病学会学術賞 肝炎、肝癌の病態と治療に関する研究
  • 2019/05 - 日本消化器病学会第3回学術賞
  • 2012/06/08 - 社団法人日本肝臓学会理事長 社団法人日本肝臓学会 織田賞
  • 2011/11 - 広島県知事感謝状「肝移植に関する調査及び研究に努力、広島県の移植医療の推進」
  • 2011/10 - 厚生労働大臣感謝状「移植医療の普及・向上のために努力、臓器移植対策の推進についての功績が顕著」
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