Rchr
J-GLOBAL ID：200901065908496313
Update date: Feb. 27, 2024
Masumoto Hiroshi
マスモト ヒロシ | Masumoto Hiroshi
Affiliation and department：
Job title：
室長
Other affiliations (1)：
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(公益財団法人)かずさDNA研究所 先端研究開発部・染色体工学研究室
室長
Homepage URL (2)：
https://www.kazusa.or.jp/laboratories/advanced-department/chromosome-lab/
,
http://www.kazusa.or.jp/en-laboratories/en-advanced-department/en-chromosome-lab/
Research field (3)：
Cell biology
, Molecular biology
, Genetics
Research theme for competitive and other funds (31)：
- 2020 - 2023 Elucidation of plant centromere formation mechanism and development of plant artificial chromosomes
- 2018 - 2020 Analyses of the chromatin on the genomic repetitive DNA involved in hierarchical and functional structures of the chromosome
- 2016 - 2019 Centromere modulation coordinating with higher order cellular functions and development of a next generation human artificial chromosome
- 2016 - 2018 染色体機能形成の階層性とゲノム反復DNA上のクロマチン構造の解明
- 2011 - 2016 The function of non-coding DNA for genome integrity
- 2011 - 2016 Analysis of chromatin network involving centromere functional components
- 2011 - 2014 Analysis of mechanism involved in the assembly balance between centromere chromatin and/or heterochromatin and in higher cellular regulation.
- 2011 - 2012 Analyses of centromeric chromatin structure
- 2010 - 2011 Development of the assay system for chromatin regulatory factors using modified centromere DNA
- 2008 - 2010 The analysis of basic chromosomal functions using human artificial chromosomes (HACs) and the development of novel HACs.
- 2008 - 2009 染色体分配異常を引き起こすメカニズムの解析
- 2008 - 2009 染色体分配装置の新規形成メカニズム
- 2007 - 2008 条件不安定化ヒト人工染色体を用いたセントロメア機能と核再形成の研究
- 1999 - 2004 染色体機能装置のダイナミクスとアルゴリズム
- 1999 - 2003 ヒト人工染色体を用いたセントロメアの高次調節機構の解析
- 1999 - 1999 ヒト人工染色体及び新規セントロメア形成における複製開始点の役割
- 1999 - 1999 哺乳動物人工染色体を用いた転写調節にかかわるクロマチン構造の解析
- 1997 - 1998 Construction of mammalian artificial chromosomes using YAC
- 1997 - 1998 Structural and Functional Analyzes of Human Artificial Chromosomes
- 1995 - 1998 染色体の核内配置とその要因
- 1996 - 1996 Construction of mammalian artificial chromosomes using YAC
- 1995 - 1995 Cloning of functional human centromere DNA by YAC technology
- 1993 - 1995 Regulation of MPF activation and Institute of Mitosis
- 1994 - 1994 Development of Human Artificial Chromosome
- 1994 - ヒト人工染色体(HAC)の構築
- 1994 - Construction of Human Artificial Chromosome(MAC)
- 1992 - 1992 ヒト染色体セントロメアに局在するCENPーB蛋白の細胞内及び試験官内での機能解析
- 1990 - 1992 染色体ドメインの機能構造
- 1989 - 1990 Functional Structure of Centromere/Kinetochore Domain of Mammalian Chromosomes
- 1984 - 哺乳動物染色体セントロメアの構造と機能の解析
- 1984 - Analysis of structure and function of centromeres on mammalian chromosomes.
Show all
Papers (73)：
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Koichiro Otake, Kazuto Kugou, Jekson Robertlee, Jun-ichirou Ohzeki, Koei Okazaki, Shigeru Hanano, Seiji Takahashi, Daisuke Shibata, Hiroshi Masumoto. De novo induction of a DNA-histone H3K9 methylation loop on synthetic human repetitive DNA in cultured tobacco cells. The Plant Journal. 2023
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Koei Okazaki, Megumi Nakano, Jun-ichirou Ohzeki, Koichiro Otake, Kazuto Kugou, Vladimir Larionov, William C. Earnshaw, Hiroshi Masumoto. Combination of CENP-B Box Positive and Negative Synthetic Alpha Satellite Repeats Improves De Novo Human Artificial Chromosome Formation. Cells. 2022. 11. 9. 1378-1378
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Junichirou Ohzeki, Kazuto Kugou, Koichiro Otake, Koei Okazaki, Seiji Takahashi, Daisuke Shibata, Hiroshi Masumoto. Introduction of a long synthetic repetitive DNA sequence into cultured tobacco cells. Plant Biotechnology. 2022
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Kazuhiko S.K. Uchida, Minji Jo, Kota Nagasaka, Motoko Takahashi, Norihisa Shindo, Katsushi Shibata, Kozo Tanaka, Hiroshi Masumoto, Tatsuo Fukagawa, Toru Hirota. Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation. Current Biology. 2021
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Elisa Pesenti, Mikhail Liskovykh, Koei Okazaki, Alessio Mallozzi, Caitlin Reid, Maria Alba Abad, A. Arockia Jeyaprakash, Natalay Kouprina, Vladimir Larionov, Hiroshi Masumoto, et al. Analysis of Complex DNA Rearrangements during Early Stages of HAC Formation. ACS Synthetic Biology. 2020. 9. 12. 3267-3287
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MISC (136)：
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大関淳一郎, 久郷和人, 岡崎考映, 中野めぐみ, 大竹興一郎, 白澤健太, 磯部祥子, 遠藤裕介, 舛本寛. Revealing histone modifications on the human centromere core region by creating a synthetic chromosome. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
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大関淳一郎, 岡崎考映, 中野めぐみ, 大竹興一郎, 白澤健太, 磯部祥子, 舛本寛. Analyzing the human centromere chromatin structure by creating a chromosome. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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Junichirou Ohzeki, Vladimir Larionov, Hiroshi Masumoto. Chromosome stability control and screening for drug discovery. 2020. 52. 412-415
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舛本寛, 高橋征司, 大関淳一郎, 久郷和人, 岡崎孝映, 大竹興一郎, 山田和子, ROBERTLEE Jekson, 山家史大, 花野滋, et al. クロマチン操作による遺伝子発現ON/OFFスイッチングプラットフォームの開発. 日本植物細胞分子生物学会大会・シンポジウム講演要旨集. 2019. 37th
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Tokuko Haraguchi, Takako Koujin, Hiroko Osakada, Tomoko Kojidani, Shouhei Kobayashi, Hiroshi Masumoto, Yasushi Hiraoka. Roles of the nuclear envelope on formation and maintenance of the micronucleus in cancer cells. CANCER SCIENCE. 2018. 109. 419-419
ｍore...
Patents (2)：
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Mammalian Artificial Chromosome
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Mammalian Artificial Chromosome
Books (4)：
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Properties and interaction of CENP-B and centromere satellite DNA in mammalian cells. In Chromosome Segregation and Aneuploidy.
EC Joint Research Center 1996
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Properties and interaction of CENP-B and centromere satellite DNA in mammalian cells. In Chromosome Segregation and Aneuploidy.
EC Joint Research Center 1996
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Properties of CENP-B and Its Target Sequence in a Satellite DNA
NATO ASI Series, Edited By Baldev K. Vig, Springer-Verlag 1993
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Properties of CENP-B and Its Target Sequence in a Satellite DNA
NATO ASI Series, Edited By Baldev K. Vig, Springer-Verlag 1993
Works (1)：
-
条件不安定化ヒト人工染色体を用いたセントロメア機能と核再形成の研究
2007 -
Education (2)：
- - 1989 Nagoya University
- - 1982 International Christian University College of Liberal Arts Division of Natural Sciences
Professional career (1)：
Work history (6)：
Association Membership(s) (2)：
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