Rchr
J-GLOBAL ID:200901066035252397
Update date: Sep. 10, 2024
Yamazaki Tomohiko
ヤマザキ トモヒコ | Yamazaki Tomohiko
Affiliation and department:
Other affiliations (2):
Homepage URL (2):
https://samurai.nims.go.jp/profiles/YAMAZAKI_Tomohiko?locale=ja
,
https://samurai.nims.go.jp/profiles/YAMAZAKI_Tomohiko?locale=en
Research field (4):
Applied biofunctional and bioprocess engineering
, Nanobioscience
, Biomaterials
, Biomedical engineering
Research keywords (6):
Toll like receptors
, Molecular imprinting
, Biosensor
, Cell Engineering
, CpG ODNs
, Protein engineering
Research theme for competitive and other funds (26):
- 2023 - 2026 Development of a nanoplastic detection sensor utilizing DNA as molecular recognition elements.
- 2023 - 2026 Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages
- 2023 - 2026 Homeostatic maintenance and activation of dental pulp quiescent stem/progenitor cells regulated by dendritic cells and macrophages
- 2022 - 2026 Corrosion control of biodegradable Mg alloys by osteoclast responsive carbonate apatite coatings
- 2021 - 2023 深紫外長残光蛍光ナノ粒子の合成と医療応用
- 2021 - 2023 Construction of type I interferon-inducing oligodeoxynucleotide using i-motif DNA structures
- 2019 - 2022 Development of corrosion protection coatings of biomedical Mg alloys showing cell adhesion changing with time
- 2018 - 2022 Regulation of the immunostimulatory activity of CpG ODNs by G-quadruplex formation
- 2018 - 2021 植物・微生物由来ヘミンからの免疫活性化ヘムポリマーの合成
- 2018 - 2021 synthesis of a hemin-containing copolymer as a novel immunostimulator
- 2017 - 2020 Development of intracellular multi-monitoring system and its application for analysis of glycation effect on tumor cells
- 2019 - 2020 ヘム含有ポリマーのワクチンアジュバントとしての商品化
- 2019 - 2020 アジュバントとして機能する酵素合成ヘモゾインナノ粒子の開発
- 2016 - 2019 Elucidation of molecular mechanism of novel iron-sulfur flavoprotein cytochrome dehydrogenase
- 2016 - 2019 Development of polymer-modified calcium phosphate coating with self-healing ability for biodegradable Mg alloys
- 2015 - 2019 Development of a hemin-containing copolymer as a novel immunostimulator
- 2017 - 2019 細胞内多標的分子計測技術を用いた糖化の腫瘍細胞へ及ぼす影響の解析
- 2018 - 2018 ナノニードルを用いた生細胞からのエクソソーム含有多胞性エンドソームの単離
- 2016 - 2018 新奇酵素、鉄硫黄フラボプロテイン・シトクロム脱水素酵素の分子機構の解明
- 2016 - 2018 生体吸収性Mg合金のための欠陥修復型ポリマー修飾リン酸カルシウム被膜の開発
- 2017 - 2017 Electrochemical Properties of Glucoside 3-Dehydrogenase, an Enzyme for 1,5-Anhydro-D-Glucitol Sensing
- 2017 - 2017 ナノニードルを用いた細胞内小胞の選択的単離
- 2015 - 2017 ヘミン誘導体から構成される免疫活性化剤の開発
- 2012 - 2014 Identification of the single-stranded DNA recognition site on human TLR9
- 2010 - 2011 Construction of self-assembled protein-based microsphere having molecular recognition ability.
- 2000 - 2002 マルチ蛋白質アレイ法の開発
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Papers (100):
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Kazuaki Hoshi, Anh Thi Tram Tu, Miwako Shobo, Karin Kettisen, Lei Ye, Leif Bülow, Yoji Hakamata, Tetsuya Furuya, Ryutaro Asano, Wakako Tsugawa, et al. Potential of Enzymatically Synthesized Hemozoin Analog as Th1 Cell Adjuvant. Nanomaterials. 2024. 14. 17. 1440-1440
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Angela Quispe-Salcedo, Tomohiko Yamazaki, Hayato Ohshima. Effects of Synthetic Toll-Like Receptor 9 Ligand Molecules on Pulpal Immunomodulatory Response and Repair after Injuries. Biomolecules. 2024. 14. 8
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Xia Li, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata. Rational design of adjuvants boosts cancer vaccines. Progress in Molecular Biology and Translational Science. 2024
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Anchu Viswan, Chiaki Yoshikawa, Ayana Yamagishi, Yuichi Furuhata, Yoshio Kato, Tomohiko Yamazaki, Chikashi Nakamura. Efficient genome editing by controlled release of Cas9 ribonucleoprotein in plant cytosol using polymer-modified microneedle array. Biochemical and Biophysical Research Communications. 2023. 686. 149179-149179
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Xia Li, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata. Nanoengineered coordination polymers boost cancer immunotherapy. MATERIALS TODAY. 2023. 67. 127-150
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MISC (31):
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山崎智彦, 山崎智彦, 星和明, TU Thi Tram Anh, TU Thi Tram Anh, 塚越かおり, 津川若子, 早出広司, 池袋一典. Gカルテット構造によるCpG ODNの免疫活性化能の向上. 日本生物工学会大会講演要旨集. 2019. 71st
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山崎智彦, 星和明, 杉山雄紀, 塚越かおり, 津川若子, 早出広司, 池袋一典. Gカルテット構造形成によるCpG ODNの免疫活性能の向上. 日本生物工学会大会講演要旨集. 2017. 69th
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YAMAZAKI Tomohiko, HANAGATA Nobutaka. 1P-269 Poly-guanosine control stimulatory activity of phosphodiester CpG oligonucleotides. 2015. 67. 156-156
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Yuvaraj Manoharan, Qingmin Ji, Tomohiko Yamazaki, Shanmugavel Chinnathambi, Song Chen, Singaravelu Ganesan, Jonathan P. Hill, Katsuhiko Ariga, Nobutaka Hanagata. Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α. International Journal of Nanomedicine. 2012. 7. 3625-3635
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MIGITA Satoshi, TSUYA Daiju, SUGIMOTO Yoshimasa, IKOMA Toshiyuki, HANAGATA Nobutaka, YAMAZAKI Tomohiko. 3P-2081 Cell cycle and size sorting of mammalian cells using a microfluidic devece. 2010. 22. 168-168
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Patents (10):
Books (6):
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Guanine Quadruplex Structure
2021
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Structural analysis of guanine quadruplex-forming oligonucleotides and their application to oligonucleotide therapeutics
2021
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バイオセンサへの応用 〜酵素燃料電池型バイオセンサから自立型バイオセンサへ〜
2011
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Biocapacitor-a Novel Bio-device Aiming the Development of Stand-alone Blood Glucose Monitoring System-
2010
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Design of novel transdriptional regulators based on substrate binding proteins
2008
more...
Lectures and oral presentations (141):
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G-quadruplex structure improves the immunostimulatory effects of CpG oligonucleotides
(第71回日本生物工学会大会 2019)
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The effects of recombinant-mouse-osteopontin over dental implant surface on direct osteogenesis in the osseointegration process
(Tooth Morphogenesis & Differentiation (TMD) conference 2019 2019)
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Isolation of multivesicular endosomes containing exosomes from living cells by nanoneedles
(2019)
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Development of novel immunostimulators, as potent vaccine adjuvants.
(CSIRO-NIMS Symposium 2019)
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Extraction of endosomes from live cells by use of antibody-functionalized nanoneedle
(2019)
more...
Education (5):
- 1997 - 2000 Tokyo University of Agriculture and Technology
- - 2000 Tokyo University of Agriculture and Technology Graduate School, Division of Engineering
- 1998 - 1999 Lund Technical University Chemical center Department of Pure and Applied Biochemistry
- 1995 - 1997 Tokyo University of Agriculture and Technology
- 1991 - 1995 Tokyo University of Agriculture and Technology Faculty of Engineering
Professional career (1):
- Ph.D. (Technology) (Tokyo University of Agriculture and Technology)
Work history (7):
Committee career (3):
- 2019/04 - 2019/10 第46回国際核酸化学シンポジウム 運営委員
- 2007/12 - 2007/12 第1回アジアバイオマテリアル学会 運営委員
- 2002/05 - 2002/05 第6回マリンバイオテクノロジー学会大会 運営委員
Association Membership(s) (3):
THE CHEMICAL SOCIETY OF JAPAN
, The Society for Biotechnology, Japan
, 日本核酸化学会
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