Asai Kiyofumi

2016 - 2019 Therapeutic strategy for rheumatoid arthritis with signal cascade control of gliostatin

2016 - 2019 Neuroprotective effect of erythropoietin by attenuating the microglia activity

2015 - 2018 Establishment of safe anesthesia methods for dementia patients

2015 - 2018 Clinical use of functional regulation of aquaporin for brain edema decrease using knockdown technique

2015 - 2018 Hypothermia attenuate brain damage by coordinating the function of glia

2014 - 2018 Molecular pharmacological analyses of calcium-activated ion channels as novel drug targets

2014 - 2017 Gliostatin as a novel therapeutic target for rheumatoid arthritis

2013 - 2017 Construction of the medical cooperation model which is strong in the large-scale disaster that utilized a recognition degree investigation into prescribed medicine

2013 - 2016 Effect of brain erythropoietin on neuron and glia in the hypoxic and ischemic damage of neonatal brain

2012 - 2015 A study searching for pain-associated biomarkers

2012 - 2015 Protective effect of hypercapnia for ventilator induced lung injury and develop a new drug for ventilator induced lung injury.

2012 - 2015 Safety anesthesia management for Alzheimer's disease

2012 - 2015 Practical use with control of aquaporin for brain edema decrease using knockdown technique

2012 - 2015 Aquaporins expression in fibroblast like synoviocytes from OA and RA patients

2011 - 2014 Positive feedback mechanism for the regulation of intracellular Ca2+ concentration and related ion channels as novel drug targets

2011 - 2013 Sp1 interference prevents joint destruction of RA through inhibitory effects of gliostatin

2011 - 2013 Analysis of boold-brain barrier breakdown in the early stage of acute encephalopathy

2010 - 2012 Functional analysis of water channel in ischemic brain injury after cardiac arrest

2010 - 2012 Elucidation of the occurrence and development of the treatment for the failure to central nerve system accompanied by severe infection

2010 - 2012 Carcinogenesis of human neuroblastoma from human neural stem cell

2010 - 2012 The significance of ES cell expressed Ras, ERas as a novel target for gastric cancer treatment

2009 - 2011 Function of a new aquaporin in the brain edema.

2009 - 2011 Functional analysis of water channel for mild hypothermia-induced brain edema decrease using knockdown technique

2008 - 2010 Mechanism of breakdown of blood-brain barrier accompanied with viral encephalopathy

2008 - 2010 Novel molecular functions of calcium-activated potassium channel as a target of drug development

2008 - 2009 胃癌の新規診断,化学療法を目指したES細胞特異的Ras,Erasの機能解析

2007 - 2009 Isolation of neuroblastoma stem cell to compare with neural stem cell

2007 - 2008 Aquaporin expression in the synovial tissues of patients with rheumatoid arthritis and osteoarthritis

2006 - 2008 analysis of water channel function to decrease of brain edema caused by mild hypothermia with using RNAi technique

2006 - 2008 Aquaporin as a target of a new therapy for brain edema

2006 - 2007 Angiogenic action of gliostatin/thymidine phosphorylase and vascular endothelial growth factor in rheumatoid arthritis and its molecular mechanism

2006 - 2007 アストロサイトの部位特異的機能分子の同定とその神経機能調節機構

2005 - 2007 血管内皮前駆細胞移植による脳毛細血管再生と遺伝子治療への応用

2005 - 2006 Analysis of cell signaling of Glia Maturation Factor-beta and-gamma in the central nervous system

2005 - 2006 Analyses of ES specific Ras, ERas function in gastric cancer and development for new chemotherapy

2005 - 2006 Regeneration of injured axons with oligodendrocytic signal-processing systems as a marker

2004 - 2005 Angiogenic action of gliostatin in rheumatoid arthritis and its molecular mechanism

2004 - 2005 Analysis of role of new protease MSP in brain injury and/or repair by gene transfection

2004 - 2005 アストロサイトによる部位特異的神経機能調節機構

2003 - 2005 Regulation mechanisms of aquaporin in the brain and its functions in the brain edema

2003 - 2004 水チャネル(アクアポリン)の発現からみた関節水腫発症機序の解明

2003 - 2004 Analysis of cell signaling of Glia Maturation Factor -beta and -gamma in the central nervous system

2002 - 2003 Arthritogenic action of gliostatin in rheumatoid arthritis and its molecular mechanism

2001 - 2003 Expression of the Water Channel in the Central Nervous System and Mechanisms of the Regulation of the Expression

2001 - 2002 プロポフォールが誘導・抑制する新規分子のDNAマイクロアレイによる検索-麻酔薬の作用機序解明を目指して-

2001 - 2002 Analysis of channel transporter after brain injury and its application for treatment

2000 - 2002 Function of GMFB and GMFG in brain development

1998 - 2001 Regional differences of astrocytic function

1999 - 2000 Application of in vitro Blood-Brain Barrier model for assessment of drug delivery to central nervous system.

1998 - 2000 Gliostatin as a clinical marker of rheumatoid arthritis and its regulation

1998 - 1999 Roles of neurotrophic factors derived from astrocyte in neuronal development

1996 - 1996 脳発達においてアストロサイト由来の神経栄養因子が果たす役割

1996 - 1996 Molecular mechanism of alcoholism : Ethanol and cell signaling

1995 - 1995 シナプス伝達系でのアストロサイトの役割

1995 - 1995 ヒト神経芽腫細胞増殖抑制因子の分子作用機構と神経芽腫治療の可能性

1994 - 1995 Neurotrophic interrelation between neuron and glia Molecular mechanism of a new glia-derived neurotrophic factor, gliostatin

1994 - 1994 ヒト神経芽腫細胞増殖抑制因子の分子作用機構と神経芽腫治療の可能性

1993 - 1993 脳血管内皮細胞による選択的透過機能発現とその調節

1993 - 1993 グリア産生因子からみた神経難病病因論の一側面

1992 - 1992 脳血管内皮細胞による選択的透過機能発現とその調節

1992 - 1992 グリア産生因子からみた神経難病病因論の一側面

1991 - 1991 血液・脳関門モデル系の確立とその応用-神経賦活剤による先天性および二次性脳障害治療の試み-

1991 - 1991 脳血管内皮細胞による選択的透過性機能発現とその調節

1991 - 1991 グリア産生因子からみた神経難病病因論の一測面

1991 - 1991 グリア細胞増殖抑制因子(GGIF)の抗腫瘍作用機構の解明とその臨床応用への可能性

1990 - 1991 Neuron-glia interaction - novel neural trophic factors and their molecular action mechanism -

1990 - 1990 グリア産生因子からみたアルツハイマ-病因論の一側面

1990 - 1990 アストログリアの腫瘍性増殖発現とグリア細胞成長因子遺伝子の活性化機構

血液脳関門の機能とその形成機構の解明

アストロサイトによる 神経機能調節機構の解明

アストロサイトの機能解析

ニューロン・グリア相関

Neuron-Glia Interaction