Matsumoto Masanori

2018 - 2021 難治性疾患実用化研究事業 高ずり応力を伴う循環器難病に随伴する出血性合併症予知法の開発

2017 - 2020 重症大動脈弁狭窄症に合併する消化管出血のフォンビレブランド因子による病態解析

2017 - 2020 難治性疾患実用化研究事業 植込型補助人工心臓装着後の出血性合併症予知法および予防法の確立に関する研究

2017 - 2020 難治性疾患実用化研究事業 機械的補助循環に合併する後天性von Willebrand症候群の治療法の開発

2017 - 2020 難治性疾患実用化研究事業 非典型溶血性尿毒症症候群(aHUS)の複合的アプローチによる診断と治療向上に関する研究

2016 - 2019 Involvement of ADAMTS 13 in liver failure after hepatectomy and establishment of novel liver failure treatment strategy

2017 - 2019 難治性疾患等政策研究事業 血液凝固異常症等に関する研究

2016 - 2019 医薬品等規制調和・評価研究事業 さらなる適正使用に向けた、血液製剤の使用と輸血療法の実施に関する研究

2015 - 2018 Study on the effects of thrombomodulin on the vascular endothelial damages in GVHD model

2014 - 2017 Establishment of new treatment targeting lifestyle diseases and coagulation fibrinolytic system related to the development of NASH

2013 - 2016 Development of novel methods for diagnosis and management of thrombotic microangiopathy following stem cell transplantation

2014 - 2015 Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy

2013 - 2015 Establishment of the diagnostic system of patients with atypical hemolytic uremic syndrome, and analysis of the characteristics of aHUS patients in Japan

2011 - 2015 Analysis of the pathology and regulation system in pregnancy-associated thrombotic microangiopathy (TMA)

2011 - 2013 重症肝障害におけるADAMTS13の生体内存在様式と制御機構

2010 - 2012 Development of novel therapy for thrombotic microangiopathy after hematopoietic stem cell transplantation.

2009 - 2011 Heterotopic living-donor partial liver transplantation as a therapy for cure of hemophilia

2008 - 2010 Determination of ADAMTS13 and its regulation mechanism in severe liver disturbance

2008 - 2010 Elucidation of mechanism of thrombus formation in older people during sporting activity and preventive measure thereof

2007 - 2009 Analysis of TMA and VOD after allogenic stem cell transplantation

2007 - 2008 Analysis of functional relationships between VWF and ADAMTS13 under blood flow conditions

2006 - 2008 Clinical relevance of VWF cleaving protease as a new doagnostic marker in liver transplant recipients

2005 - 2007 ADAMTS13の解析と重症肝疾患における微小循環障害の発生機序の解明

2005 - 2007 Novel antithrombotic strategy based on the functional regulation of factor VIII/VWF complex

2005 - 2006 Potential Role of Dehydration on Thrombogenic Processes during Exercise

2004 - 2006 Analysis of ADATS13 in TMA patients with severe renal damage

2003 - 2005 Analysis of various type thrombosis with decreased ADAMTS13 activity

2003 - 2004 Study on the prediction of thrombosis formation during exercise

2001 - 2002 フォンビルブランド因子特異的切断酵素のモノクローナル抗体を用いた精製と構造機能解析

1999 - 2001 MOLECULAR DESIGN OF INHIBITORS ON THE FORMATION OF VON WILLEBRAND FACTOR-DEPENDENT PLATELET THROMBI

血栓性微小血管障害症(TMA)

フォンビルブランド因子特異的切断酵素(ADAMTS13)

placental ecto-ATP diphosphohydrolase(ATPDase)

von Willebrand factor cleaving protease.(ADAMTS13)