Rchr
J-GLOBAL ID：200901066937162633   Update date: Nov. 01, 2025

ISHIHARA Hisamitsu

イシハラ ヒサミツ | ISHIHARA Hisamitsu
Affiliation and department：
Nihon University School of Medicine Department of Medicine -

About Nihon University School of Medicine Department of Medicine -


Job title： Professor
Research field  (1)： Metabolism and endocrinology
Research keywords  (1)： pathogenesis of diabetes mellitus
Research theme for competitive and other funds  (22)：
  • 2024 - 2027 Molecular mechanisms underlying metabolism-secretion coupling in endocrine cells of the islets of Langerhans
  • 2020 - 2023 膵島ホルモン分泌細胞の代謝特性の解析と偽膵島作製による代謝・分泌障害機構の解明
  • 2017 - 2020 Elucidation of insulin secretory mechanisms through large scale generation of genetically-modified insulin secreting cells and omics analysis
  • 2012 - 2015 Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs
  • 2010 - 2012 Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas
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Papers (171)：
  • Kentaro Watanabe, Hidenori Nishioka, Masahiro Takubo, Minami Kosuda, Takeshi Yamamotoya, Taro Saigusa, Hisamitsu Ishihara. Pericardial fat pad detected on chest X-ray is closely associated with metabolic dysfunction-associated steatotic liver disease and visceral fat accumulation in patients with type 2 diabetes. Journal of Diabetes and its Complications. 2025. 39. 10. 109150-109150
  • Midori Fujishiro, Maiko Nosoko, Jin Ikeda, Misaki Takeuchi, Takeshi Yamamotoya, Tadateru Takayama, Tatsuhiko Urakami, Katsuhiko Ogawa, Hisamitsu Ishihara. Acetonemic vomiting: a potential complication of treatment with glucagon-like peptide-1 receptor agonists especially in lean type 2 diabetes patients. Diabetology international. 2025. 16. 1. 162-168
  • Naoya Watanabe, Yukiko K. Kaneko, Hisamitsu Ishihara, Ryota Shizu, Kouichi Yoshinari, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa. Diacylglycerol kinase ζ is a positive insulin secretion regulator in pancreatic β-cell line MIN6. Biochemical and Biophysical Research Communications. 2025
  • 林 亜莉沙, 田久保 正洋, 長澤 瑛子, 小須田 南, 江頭 富士子, 渡邉 健太郎, 石原 寿光. 免疫チェックポイント阻害薬によるirAEで発症した膵島関連自己抗体陽性1型糖尿病の2例. 糖尿病. 2024. 67. 7. 306-306
  • 井戸田 裕貴, 齊藤 一樹, 市川 智香子, 青木 倫子, 小須田 南, 三枝 太郎, 江頭 富士子, 渡邉 健太郎, 石原 寿光. 免疫関連副作用(irAE)により発症した抗GAD抗体陽性劇症1型糖尿病の1例. 日本内科学会関東地方会. 2024. 696回. np25-np25
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MISC (71)：
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Books (8)：
  • 糖尿病専門医研修ガイドブック
    診断と治療社 2017
  • 内科学(第11版)
    朝倉書店 2017
  • ER stress and apoptosis in β cells during the development of diabetes mellitus
    2009
  • Molecular diabetology: Generation of insulin secretory signals in the mitochondria of β-cells
    2009
  • The evolution of research on insulin secretion by mitochondria: derived factors
    2008
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Lectures and oral presentations  (51)：
  • Therapy combining glucagon-like peptide-1 receptor agonist with sodium-glucose cotransporter 2 Inhibitor suppresses atherosclerosis in diabetic ApoE-deficient mice
    (Exp Clin Endocrinol Diabetes 2024)
  • 2型糖尿病と続発性高トリグリセリド血症を発症したウエイトリフティング学生選手の1例
    (日本成人病(生活習慣病)学会会誌 2024)
  • 急性膵炎の治療後に発症し,心筋炎を合併した劇症1型糖尿病の一例
    (糖尿病 2023)
  • 肥満2型糖尿病を発症した成人フェニルケトン尿症の一例
    (日本病態栄養学会誌 2023)
  • 急性膵炎の治療後に発症し,心筋炎を合併した劇症1型糖尿病の一例
    (糖尿病(Web) 2023)
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Education (1)：
  • - 1988 The University of Tokyo Faculty of Medicine
Awards (1)：
  • 2009/05 - The Lilly Award The Molecular Mechanisms of Pancreatic Beta-cell Failure in Type 2 Diabetes Mellitus
Association Membership(s) (7)：
米国糖尿病学会 ,  日本生化学学会 ,  日本成人病学会 ,  日本糖尿病合併症学会 ,  日本内分泌学会 ,  日本糖尿病学会 ,  日本内科学会
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