Rchr
J-GLOBAL ID：200901066937162633
Update date: Mar. 06, 2024
ISHIHARA Hisamitsu
イシハラ ヒサミツ | ISHIHARA Hisamitsu
Affiliation and department：
Job title：
Professor
Research field (1)：
Metabolism and endocrinology
Research keywords (1)：
pathogenesis of diabetes mellitus
Research theme for competitive and other funds (21)：
- 2020 - 2023 膵島ホルモン分泌細胞の代謝特性の解析と偽膵島作製による代謝・分泌障害機構の解明
- 2017 - 2020 Elucidation of insulin secretory mechanisms through large scale generation of genetically-modified insulin secreting cells and omics analysis
- 2012 - 2015 Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs
- 2010 - 2012 Molecular mechanism of regulation of expression and identificati on of novel target gene of vitamin D in the pancreas
- 2009 - 2011 Molecular mechanisms of pancreaticβ-cell failure and insulin resistance due to impaired ER stress response
- 2007 - 2010 Pancreatic β cell impairment and adaptation of type 2 diabetes mellitus in overnutrition era
- 2007 - 2008 The molecular mechanisms of transcriptional and translational control of stress responses in pancreatic β cells
- 2006 - 2008 動脈硬化早期診断法の確立-血管壁の電子的染色法を用いて
- 2006 - 2007 ミトコンドリア遺伝子異常糖尿病に対する遺伝子治療の開発
- 2005 - 2006 Signaling axis of urotensin II, parasympathetic nerves, and nitric oxide on carbohydrate metabolism: A clinical
- 2005 - 2006 Molecular Mechanisms for Pancreatic Islet Disfunction in Development of Diabetes Mellitus-a study using WFS1 knockout mice
- 2005 - 2006 Molecular mechanisms for pancreatic beta cell failure・a viewpoint from endoplasmic reticulum stress
- 2004 - 2005 膵ラ島β細胞ミトコンドリアを標的とする遺伝子治療の開発
- 2004 - 2005 The role of genes of forkhead transcription factors in type2 diabetes and obesity.
- 2004 - 2005 Elucidation of abnormality of plasma membrane microdomain in type 2 diabetes mellitus
- 2001 - 2005 Elucidation of diabetes-related genes
- 2003 - 2004 転写ターゲティングシステム構築による膵島ホルモン分泌制御機構の解析と遺伝子治療
- 2003 - 2004 Development of gene therapy for diabetes associated with obesity
- 2002 - 2003 The role of phospholipase D in the development of diabetes mellitus
- 2002 - 2003 The role of plasma membrane type sialidase gene Neu3 on the pathogenesis of type 2 diabetes mellitusin Japanese.
- 遺伝子改変インスリン分泌細胞株の効率的作製法開発とインスリン分泌機構解明への応用
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Papers (153)：
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Midori Fujishiro, Sho Tanaka, Kentaro Watanabe, Kazuhiro Imatake, Yasuyuki Suzuki, Hisamitsu Ishihara, Shigemasa Tani. Association of Glycated Hemoglobin Level with Self-Reported Chewing Problems in Elderly Community-Dwelling Individuals in Japan. Journal of Multidisciplinary Healthcare. 2023. 16. 1231-1238
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Aya Tanaka, Minami Kosuda, Midori Yamana, Asami Furukawa, Akiko Nagasawa, Midori Fujishiro, Genta Kohno, Hisamitsu Ishihara. A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness. Scientific Reports. 2023. 13. 1
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Tomofuji Y, Suzuki K, Kishikawa T, Shojima N, Hosoe J, Inagaki K, Matsubayashi S, Ishihara H, Watada H, Ishigaki Y; BioBank Japan Project; Inohara H, et al. Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med. 2023. 5. 1. 5-5
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Tanaka S, Fujishiro M, Imatake K, Suzuki Y, Ishihara H, Tani S. Impact of Female Sex on the Susceptibility to Hypernatremia Among Older Community-Dwelling Individuals in Japan. Int J Gen Med. 2022. 15. 777-785
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Watanabe K, Takakubo N, Saigusa T, Nagasawa A, Yamana M, Ojima M, Kameda W, Susa S, Ishizawa K, Ishihara H. Fibrosis-4 index is closely associated with arterial damage and future risk of coronary heart disease in type 2 diabetes. Int J Hyperten. 2022. 2022
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MISC (61)：
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野田日菜子, 山名碧, 中山香桜里, 小須田南, 三枝太郎, 江頭富士子, 渡邉健太郎, 石原寿光, 河野通成. 2型糖尿病入院中に重症の下肢動脈閉塞と診断し血行再建術に至った1例. 糖尿病(Web). 2022. 65. 7
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田久保正洋, 小須田南, 長澤瑛子, 山名碧, 江頭富士子, 渡邉健太郎, 今津博雄, 石原寿光. 2型糖尿病の経過中に多脾症合併膵体尾部低形成症が判明した1例. 糖尿病(Web). 2021. 64. 7
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Egashira F, Kawashima M, Morikawa A, Kosuda M, Ishihara H, Watanabe K. A rare case of fulminant type 1 diabetes mellitus accompanied by both acute pancreatitis and myocarditis - case report. BMC Endocr Disord. 2020. 20. 1. 127-127
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Hisamitsu Ishihara, Hidenori Nishioka, Midori Yamana, Akiko Nagasawa, Minami Kosuda, Masao Koike, Genta Kohno, Hitoki Saito. Roles of Glycolysis Distinct from Mitochondrial Metabolism for Signal Generation in Insulin-Secreting Cells. DIABETES. 2020. 69
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西岡秀典, 山名碧, 長澤瑛子, 小須田南, 渡邉健太郎, 石原寿光. ミトコンドリアピルビン酸輸送担体欠損インスリン分泌細胞株の樹立と解析. 糖尿病(Web). 2020. 63. Suppl
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Books (3)：
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糖尿病専門医研修ガイドブック
診断と治療社 2017
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内科学(第11版)
朝倉書店 2017
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WFS1 protein (Wolframin): emerging link between the emotional brain and endocrine pancreas
Research Signpost 2008
Lectures and oral presentations (21)：
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グルコース応答性インスリン分泌におけるTCA回路酵素の役割の検討
(第65回日本糖尿病年次学術集会 2022)
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Prevention and Treatment of Diabetes in Asia
(International Nutrition Symposium for Diabetes 2019)
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Tofogliflozin is a better candidate than glimepiride for the third line oral agent added to the metformin/DPP-4 inhibitor dual therapy: results of a drandamized control trial
(55th Annual Meeting of the European Association for the Study of Diabetes 2019)
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Overexpression Screening Identifies Mitochondrial Carbonic Anhydrase 5b as an Important Regulator of Glucose-Stimulated Insulin Secretion in Beta Cells
(79th American Diabetes Association Meeting 2019)
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Featured Symposium 2: Future of Diabetes Care
(第62回 日本糖尿病学会年次学術集会 2019)
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Education (1)：
- - 1988 The University of Tokyo Faculty of Medicine
Awards (1)：
- 2009/05 - The Lilly Award The Molecular Mechanisms of Pancreatic Beta-cell Failure in Type 2 Diabetes Mellitus
Association Membership(s) (7)：
米国糖尿病学会
, 日本生化学学会
, 日本成人病学会
, 日本糖尿病合併症学会
, 日本内分泌学会
, 日本糖尿病学会
, 日本内科学会
