Rchr
J-GLOBAL ID：200901067118684104   Update date: Jul. 07, 2024

HAMADA Kozo

ハマダ コウゾウ | HAMADA Kozo
Affiliation and department：
Xian Jiaotong Liverpool University (XJTLU) School of Science

About Xian Jiaotong Liverpool University (XJTLU) School of Science


Job title： Associate Professor (PI)
Research keywords  (21)： IP3 receptor ,  Dimentia ,  signal transduction ,  receptor ,  Aging ,  tau ,  Alzheimer's disease ,  structural biology ,  electron microscopy ,  X-ray crystallography ,  autophagy ,  calcium signaling ,  Huntington disease ,  polyglutamine disease ,  neurodegenerative disease ,  transglutaminase ,  endoplasmic reticulum ,  ion channel ,  neurochemistry ,  biomedical chemistry ,  biochemistry
Research theme for competitive and other funds  (6)：
  • 2021 - 2024 Role of Ca2+ signaling at ER microdomains in dementia
  • 2015 - 2021 小胞体カルシウムチャネルのアロステリック制御異常による認知症の発症機序
  • 2017 - 2019 タンパク質老化と毒性機序における小胞体カルシウムの役割
  • 2015 - 2018 光刺激反応系を用いたCa2+依存的膵外分泌機構の解明
  • 2015 - 2017 タウタンパク質老化と毒性機序における小胞体カルシウムの役割
Show all
Papers (31)：
  • Lavik AR, McColl KS, Lemos FO, Kerkhofs M, Zhong F, Harr M, Schlatzer D, Hamada K, Mikoshiba K, Crea F, et al. A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors. Biochim Biophys Acta Mol Cell Res. 2022. 1869. 4. 119206
  • Rosa N, Ivanova H, Wagner LE, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, et al. Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis. Cell Death Differ. 2022. 29. 4. 788-805
  • Yuki Kanda, Ryosuke Satoh, Teruaki Takasaki, Naofumi Tomimoto, Kiko Tsuchiya, Chun An Tsai, Taemi Tanaka, Shu Kyomoto, Kozo Hamada, Toshinobu Fujiwara, et al. Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast. J Cell Sci. 2021. 134. 2
  • Hamada K, Mikoshiba K. IP3 Receptor Plasticity Underlying Diverse Functions. Annual Review of Physiology. 2020. 82. 151-176
  • Lili Yue, Liuqing Wang, Yangchun Du, Wei Zhang, Kozo Hamada, Yoshifumi Matsumoto, Xi Jin, Yandong Zhou, Katsuhiko Mikoshiba, Donald L Gill, et al. Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells. Cells. 2020. 9. 2
ｍore...
MISC (5)：
  • 杉本恵崇, 高崎輝恒, 佐藤亮介, 濱田耕造, 杉浦麗子. 分裂酵母モデル系を用いたα-シヌクレイン凝集体形成メカニズムの探索とメンブレントラフィックの関わり. 日本薬理学雑誌. 2020. 155. Supplement
  • 濱田耕造, 宮武秀行, 寺内明子, 御子柴克彦. IP3受容体の結晶構造からひもとくアロステリック機構と疾病メカニズム. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2AW07-1 (WEB ONLY)-1]
  • 宮本 浩行, 中丸 映子, 濱田 耕造, ヘンシュ 貴雄. 睡眠中の脳活動と神経回路網 セロトニン系によって統合されるサーカディアン振動体と睡眠・覚醒交替. 日本睡眠学会定期学術集会プログラム・抄録集. 2012. 37回. 168-168
  • Hiroyuki Miyamoto, Kozo Hamada. Functional dissociation between the circadian clock in the suprachiasmatic nucleus and sleep-wake cycle after brain serotonin depletion. NEUROSCIENCE RESEARCH. 2010. 68. E178-E178
  • 高井 克治, 中丸 映子, 浜田 耕造, 宮本 浩行, 塚田 幸治, 上平 幸広, 角井 信一, 神山 吉輝, FIERRO Ramon del, 星本 弘之, et al. 脳活動基調と広域調節型神経伝達物質代謝の水準遷移 : 内在性の領域・時間特性, 相互関連, 誘発・擾乱応答. 日本分子生物学会年会プログラム・講演要旨集. 1996. 19. 358-358
Patents (3)：
Books (4)：
  • Gating mechanism of calcium channels in the endoplasmic reticulum
    NTS inc 2018
  • New evidence for gating mechanism of the IP3 receptor
    Jikken Igaku 2018
  • 小胞体ストレス, レドックス制御, カルシウムシグナルと神経細胞死
    実験医学 2012
  • イノシトール三リン酸受容体の構造と機能制御
    実験医学 2003
Lectures and oral presentations  (20)：
  • IP3-Mediated Gating Mechanism of IP3 Receptor
    (Gordon Research Conference (US) 2018)
  • Allosteric Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-ray Crystallography, and Its Implications for Diseases
    (Consortium of Biological Sciences 2017 2017)
  • Gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography
    (2017)
  • Gating Mechanism of IP3 Receptors
    (Osaka University, IPR Seminar 2017)
  • Gating Mechanism of IP3 Receptors Revealed by Mutagenesis and X-Ray Crystallography (Late-Breaking Topics)
    (Gordon Research Conference (Italy) 2017)
ｍore...
Education (4)：
  • 1993 - 1998 The University of Tokyo Institute of International Health Department of Biomedical Chemistry
  • 1991 - 1993 The University of Tokyo School of Health Science Department of Biochemistry and Nutrition
  • 1989 - 1991 The University of Tokyo School of Health Science Department of Biochemistry and Nutrition
  • 1987 - 1989 The University of Tokyo Natural Science II
Professional career (3)：
  • Ph. D. (The University of Tokyo)
  • M. Sc. (The University of Tokyo)
  • B. S. (The University of Tokyo)
Work history (6)：
  • 2023/07 - 現在 Xian Jiaotong Liverpool University (XJTLU) Department of Biological Sciences, School of Science Associate Professor, Principal Investigator (PI)
  • 2019/04 - 2023/06 ShanghaiTech university Associate Professor
  • 2018/11 - 2019/03 Kindai Unversity Faculty of pharmacy Researcher
  • 2010 - 2018/10 RIKEN BSI Researcher
  • 2003 - 2010 Japan Science and Technology Agency ICORP Researcher
Show all
Association Membership(s) (2)：
THE JAPANESE BIOCHEMICAL SOCIETY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM