Akiyama Taishin

アキヤマタイシン | Akiyama Taishin

Affiliation and department：
Job title： Team Leader
Other affiliations (1)：

Yokohama City University Graduate School of Medical Life Science Guest Professor

Homepage URL (1)： https://www.ims.riken.jp/labo/28/index_j.html

Research field (2)： Immunology , Molecular biology

Research keywords (6)：胸腺 , 上皮細胞 , リンパ組織 , 自己免疫 , サイトカイン , 免疫寛容

Research theme for competitive and other funds (23)：

2023 - 2028 Functional analysis of Gene Desert as an enhancer reservoir in the establishment of cell lineage commitment and its diversity
2021 - 2024 Establishment of thymic central tolerance toward non-self antigens
2020 - 2023 胸腺上皮細胞の多様性による自己免疫疾患の発症抑制
2018 - 2020 宇宙環境によるリンパ組織擾乱の分子機構解明
2017 - 2020 Quantitative Immunology of T cell homeostasis

2017 - 2020 Identification of the transcriptinal regulator that controls functions of thymic epithelial cells required for immune tolerance

2016 - 2018 重力依存的な胸腺組織微小環境の機能制御

2015 - 2017 自己免疫寛容に必要な胸腺上皮細胞の特性を決定する分子機構の解明

2014 - 2016 Contribution of imperfect elimination of self-reactive T cells in the thymus to tumor immune surveillance

2012 - 2015 Molecular mechanisms underlying formation of lymphatic tissue microenvironment required for preventing autoimmunity

2012 - 2014 Epigenetic regulation by transcription factor NF-kappaB

2010 - 2011 胸腺発生型の制御性T細胞分化を決定するTRAF6シグナル標的因子の同定

2010 - 2011 Mimetic virus-infection in thymic medullary microenvironment

2009 - 2011 Identification of mechanism underlying transcriptional regulation in microenvironment formation essential for immunological self-tolerance

2008 - 2009 自己免疫寛容を誘導するNF-κB活性化シグナル制御機構の解明

2008 - 自己免疫寛容を誘導するNF-kB活性化シグナル制御機構の解明

2006 - 2007 Mechanism for differentiation of thymic epithelial cells to establish immunological self-tolerance

2006 - 2007 細胞内シグナル伝達経路の人為的制御による癌免疫療法の強化

2006 - 2007 2次リンパ組織の微小環境形成を制御するシグナルネットワークの解明

2007 - 胸腺依存的な免疫寛容を制御する基盤技術の開発

2004 - 2005 Analysis of molecular mechanism in the differentiation of thymic medullar epithelial cells essential for self-tolerance induction

2000 - 2004 転写制御の異常と細胞の増殖・分化

1998 - 1999 DNA切断によるエイズプロウイルスの不活性化を目指した新規化合物の分子設計

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Papers (50)：

Yuki Takakura, Moeka Machida, Natsumi Terada, Yuka Katsumi, Seika Kawamura, Kenta Horie, Maki Miyauchi, Tatsuya Ishikawa, Nobuko Akiyama, Takao Seki, et al. Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity. Nature Communications. 2024. 15. 1
Kenta Horie, Kano Namiki, Kyouhei Kinoshita, Maki Miyauchi, Tatsuya Ishikawa, Mio Hayama, Yuya Maruyama, Naho Hagiwara, Takahisa Miyao, Shigeo Murata, et al. Acute irradiation causes a long-term disturbance in the heterogeneity and gene expression profile of medullary thymic epithelial cells. Frontiers in Immunology. 2023. 14
Tatsuya Ishikawa, Kenta Horie, Yuki Takakura, Houko Ohki, Yuya Maruyama, Mio Hayama, Maki Miyauchi, Takahisa Miyao, Naho Hagiwara, Tetsuya J. Kobayashi, et al. T-cell receptor repertoire analysis of CD4-positive T cells from blood and an affected organ in an autoimmune mouse model. Genes to Cells. 2023
Yuya Maruyama, Yusuke Ohsawa, Takayuki Suzuki, Yuko Yamauchi, Kohsuke Ohno, Hitoshi Inoue, Akitoshi Yamamoto, Morimichi Hayashi, Yuji Okuhara, Wataru Muramatsu, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist. 2023
Tatsuya Ishikawa, Kenta Horie, Yuki Takakura, Houko Ohki, Yuya Maruyama, Mio Hayama, Maki Miyauchi, Takahisa Miyao, Nobuko Akiyama, Taishin Akiyama. Correlation of blood TCR repertoire with an organ manifestation in a mouse model of autoimmune disease. 2023

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MISC (9)：

Taishin Akiyama, Tadashi Yamamoto. Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex. Frontiers in Immunology. 2021. 12
Taishin Akiyama, Miho Shinzawa, Junwen Qin, Nobuko Akiyama. Regulations of gene expression in medullary thymic epithelial cells required for preventing the onset of autoimmune diseases. FRONTIERS IN IMMUNOLOGY. 2013. 4
Taishin Akiyama, Miho Shinzawa, Nobuko Akiyama. TNF receptor family signaling in the development and functions of medullary thymic epithelial cells. Frontiers in Immunology. 2012. 3
Taishin Akiyama, Yusuke Shimo, Hiromi Yanai, Jun-wen Qin, Jun-ichiro Inoue. THE TNF-FAMILY RECEPTORS RANK AND CD40 COOPERATIVELY REGULATE CENTRAL TOLERANCE IN THYMUS. ADVANCES IN TNF FAMILY RESEARCH. 2011. 691. 691-692
Taishin Akiyama, Yusuke Shimo, Hiromi Yanai, Junwen Qin, Daisuke Ohshima, Yuya Maruyama, Yukiko Asaumi, Juli Kitazawa, Hiroshi Takayanagi, Josef M. Penninger, et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. IMMUNITY. 2008. 29. 3. 423-437

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Education (2)：

Hiroshima University
Kyoto University

Professional career (1)：

Ph.D. (Kyoto University)

Work history (2)：

2019/04 - 現在 Yokohama City University Graduate School of Medical Life Science Guest Professor
2017/07 - 現在 RIKEN Center for Integrative Medical Sciences Team Leader

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