Rchr
J-GLOBAL ID：200901067251760514
Update date: Oct. 31, 2024
Sugishima Masakazu
スギシマ マサカズ | Sugishima Masakazu
Affiliation and department：
Homepage URL (1)：
https://sites.google.com/view/msugishima76
Research field (3)：
Structural biochemistry
, Biophysics
, Functional biochemistry
Research keywords (4)：
Protein Crystallography
, Structural Biology
, タンパク質結晶学
, 構造生物学
Research theme for competitive and other funds (17)：
- 2022 - 2025 Mechanism of construction and cyclization of the heme precursor tetrapyrrole
- 2021 - 2024 ペプチドC末端アミド化酵素がIDH変異を伴う悪性腫瘍に及ぼす影響
- 2020 - 2023 Construction of bilin reductase library, promotes next-generation optogenetics.
- 2019 - 2022 Structural study of cytochrome P450-reductase complex to elucidate electron transfer mechanism
- 2018 - 2021 Elucidation of the construction mechanism of porphyrin ring essential for organisms: Formation and cyclization of tetrapyrrole
- 2016 - 2019 Elucidation of Reaction Mechanism of Bili Reductase by Multiple Methods Mainly Neutron Structure Analysis
- 2016 - 2019 Elucidation of the electron transfer mechanism from cytochrome P450 oxidoreductase to cytochrome P450
- 2015 - 2018 Investigation of biosynthetic mechanism of cyclic tetrapyrrole: Construction and cyclization of hydroxymethylbilane
- 2014 - 2017 Studies on structural biology of the enzymes involved in porphyria
- 2013 - 2016 Structure determination of heme oxygenase bound to its weakly interacted protein
- 2012 - 2015 Electron transfer sytem to heme oxygenase from cytochrome P450
- 2011 - 2014 Elucidation of mechanisms of bilin synthesizing enzyme and photo-adaptation regulating protein
- 2009 - 2011 Investigation of the intermediary steps and electron transfer mechanism of heme degradation by heme oxygenase
- 2008 - 2010 Elucidation of molecular mechanism of bilin synthesis by ferredoxin-dependent bilin reductases
- 2008 - 2010 Structural and biochemical studies about electron pathways in heme oxygenase-redox counterpart complex
- 2006 - 2008 PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATURE
- 2005 - 2006 脳内のCOセンサー蛋白質NPAS2の立体構造解析
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Papers (49)：
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Tatsuya Joutsuka, Ryota Nanasawa, Keisuke Igarashi, Kazuki Horie, Masakazu Sugishima, Yoshinori Hagiwara, Kei Wada, Keiichi Fukuyama, Naomine Yano, Seiji Mori, et al. Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutants reveal substrate and catalytic residue protonation states. Journal of Biological Chemistry. 2023. 299. 1. 102763-102763
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Hideaki Sato, Masakazu Sugishima, Mai Tsukaguchi, Takahiro Masuko, Mikuru Iijima, Mitsunori Takano, Yoshiaki Omata, Kei Hirabayashi, Kei Wada, Yoshio Hisaeda, et al. Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps. The Biochemical journal. 2021. 478. 5. 1023-1042
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Keita Miyake, Keiji Fushimi, Tomonori Kashimoto, Kaisei Maeda, Ni-Ni-Win, Hiroyuki Kimura, Masakazu Sugishima, Masahiko Ikeuchi, Rei Narikawa. Functional diversification of two bilin reductases for light perception and harvesting in unique cyanobacterium Acaryochloris marina MBIC 11017. The FEBS Journal. 2020. 287. 18. 4016-4031
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Masakazu Sugishima, Junichi Taira, Tatsuya Sagara, Ryota Nakao, Hideaki Sato, Masato Noguchi, Keiichi Fukuyama, Ken Yamamoto, Takuo Yasunaga, Hiroshi Sakamoto. Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction. Antioxidants. 2020. 9. 8. 673-673
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Masakazu Sugishima, Kei Wada, Keiichi Fukuyama, Ken Yamamoto. Crystal structure of phytochromobilin synthase in complex with biliverdin IXα, a key enzyme in the biosynthesis of phytochrome. Journal of Biological Chemistry. 2020. 295. 3. 771-782
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MISC (40)：
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Sugishima, M., Wada, K., Fukuyama, K. Recent advances in the understanding of the reaction chemistries of the heme catabolizing enzymes HO and BVR based on high resolution protein structures. Current Medicinal Chemistry. 2020. 27. 21
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Sugishima, M., Wada, K., Unno, M., Fukuyama, K. Bilin-metabolizing enzymes: site-specific reductions catalyzed by two different type of enzymes. Current Opinion in Structural Biology. 2019. 59. 73-80
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下川 千寿, 城田 沙織, 田, 佐藤 秀明, 杉島 正一, 原田 二朗, 東元 祐一郎, Amzel Mario, 野口 正人. 癌代謝物である2-ヒドロキシグルタル酸がヒト由来ペプチドC末端アミド化酵素PAMに与える影響. 生命科学系学会合同年次大会. 2017. 2017年度. [3P-0200]
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Masakazu Sugishima. Structural study of enzymes involved in heme metabolism. Seikagaku. 2016. 88. 2. 171-181
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Masaki Unno, Kumiko Ishikawa-Suto, Katsuhiro Kusaka, Taro Tamada, Yoshihiro Hagiwara, Masakazu Sugishima, Kei Wada, Makiko Ishihara, Keiichi Fukuyama. Neutron Crystallography Reveals Two Protonation States of PcyA, a Bilin Reductase. J-PARC ANNUAL REPORT 2014. 2016. Vol. 2
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Books (1)：
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Structure and reaction mechanism of heme oxygenase-1
International Congress Series 2002
Works (2)：
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ヘムオキシグナーゼの構造と機能に関する共同研究
1998 -
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Joint Research on Structure and function of heme oxygenase
1998 -
Education (2)：
- 1999 - 2004 Osaka University Graduate School of Science Department of Biological Sciences
- 1995 - 1999 Osaka University School of Science
Professional career (1)：
- (BLANK) (Osaka University)
Work history (6)：
- 2012/11 - 現在 Kurume University School of Medicine
- 2008/02 - 2012/10 Kurume University School of Medicine
- 2010/08 - 2012/07 University of Chicago Department of Biochemistry and Molecular Biology Visiting Scholar
- 2007/04 - 2008/01 Kurume University School of Medicine
- 2005/04 - 2007/03 日本学術振興会 特別研究員
- 2004/04 - 2005/03 Osaka University Graduate School of Science, Department of Biological Sciences
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Committee career (1)：
- 2022/04 - 2024/03 日本結晶学会 編集委員
Awards (5)：
- 2024/11 - 日本結晶学会 学術賞 ポルフィリン代謝酵素群の構造研究
- 2015/12 - 日本生化学会 奨励賞 ヘム代謝関連酵素の構造生物学的研究
- 2015/04 - 文部科学省 科学技術分野の文部科学大臣表彰 若手科学者賞 ヘム代謝関連酵素の立体構造と機能に関する研究
- 2013/05 - 日本生化学会九州支部 学術奨励賞 ヘムオキシゲナーゼによるCOとO2の識別機構に関する構造生物学的研究
- 2006/11 - 日本結晶学会 進歩賞 ヘムの代謝に関する酵素群の構造生物学
Association Membership(s) (4)：
日本蛋白質科学会
, 日本生物物理学会
, 日本結晶学会
, 日本生化学会
