Rchr
J-GLOBAL ID：200901067335196533   Update date: Feb. 14, 2024

Obinata Hideru

オビナタ ヒデル | Obinata Hideru
Affiliation and department：
Gunma University Graduate School of Medicine Education and Research Support Center

About Gunma University Graduate School of Medicine Education and Research Support Center


Job title： Associate Professor
Research field  (1)： Medical biochemistry
Research theme for competitive and other funds  (20)：
  • 2022 - 2025 Elucidation of pathophysiological roles of capillary endothelial cell-anchored protein, GPIHBP1, in dyslipidemia
  • 2022 - 2025 Exome and lipidome analysis to elucidate the mechanisms of sudden death with hepatic steatosis
  • 2021 - 2024 膵がん治療におけるO-GlcNAc分解酵素OGAの重要性とその分子機構の解明
  • 2021 - 2024 Elucidation of a novel cellular senescence mechanism modulated by branched-chain amino acid metabolism.
  • 2021 - 2024 Regulation of chronic inflammation of blood vessels by a bioactive lipid mediator
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Papers (48)：
  • Xian Zhao, Keisuke Kiyozuka, Akimitsu Konishi, Reika Kawabata-Iwakawa, Yoji Andrew Minamishima, Hideru Obinata. Actin-binding protein Filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1. The Journal of biological chemistry. 2023. 104851-104851
  • Keisuke Kiyozuka, Xian Zhao, Akimitsu Konishi, Yoji Andrew Minamishima, Hideru Obinata. Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3. Journal of biochemistry. 2023
  • Kawakami Ryo, Hanaoka Hirofumi, Kanai Ayaka, Obinata Hideru, Matsui Miki, Matsui Hiroki, Koitabashi Norimichi, Yokoyama Tomoyuki, Ishii Hideki, Kurabayashi Masahiko, et al. Unappreciated Mechanisms of Fatty Acid Uptake in the Kidney: Fatty Acids are Taken up from Both Basolateral and Apical Side(和訳中). 日本循環器学会学術集会抄録集. 2022. 86回. OE20-5
  • Weiru Jiang, Toshikazu Kakizaki, Kazuyuki Fujihara, Shigeo Miyata, Yue Zhang, Takashi Suto, Daiki Kato, Shigeru Saito, Koji Shibasaki, Yasuki Ishizaki, et al. Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022. 36. 2. e22123
  • Yogi Umbarawan, Ryo Kawakami, Mas Rizky A A Syamsunarno, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Norimichi Koitabashi, Hiroaki Sunaga, et al. Reduced Fatty Acid Use from CD36 Deficiency Deteriorates Streptozotocin-Induced Diabetic Cardiomyopathy in Mice. Metabolites. 2021. 11. 12
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MISC (36)：
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Patents (4)：
  • Endothelium protective materials and methods of use
  • 5-oxo-ETE受容体を活性化するペプチドとその誘導体
  • Agonist to G protein-coupled receptor G2A and method of screening G2A activity controller
  • Gタンパク質共役型受容体G2Aの作動薬、及びG2A活性調節薬のスクリーニング方法
Books (5)：
  • 実験医学増刊 脂質クオリティ
    羊土社 2018
  • 遺伝子医学MOOK 最新生理活性脂質研究 -実験手法、基礎的知識とその応用- (監修 横溝岳彦)
    メディカルドゥ 2013
  • 実験医学増刊 分子から個体へと深化する脂質生物学 (編集 佐々木雄彦、横溝岳彦、竹縄忠臣)
    羊土社 2010
  • 麻酔管理に関連する受容体(編集 大下修造)
    真興交易(株)医書出版部 2003 ISBN:4880037036
  • ポストシークエンスタンパク質実験法4 構造・機能解析の実際(大島泰郎・鈴木紘一・藤井義明・村松喬 編)
    東京化学同人 2003 ISBN:4807911376
Lectures and oral presentations  (68)：
  • Regulation of S1P functions by a chaperone system
    (The 92nd Annual Meeting of the Japanese Biochemical Society 2019)
  • 家庭環境内における重金属類暴露シナリオの解明ー調査方法の確立
    (第89回日本衛生学会学術総会 2019)
  • Novel S1P chaperone activity in the plasma from ApoM/albumin-double knockout mice
    (2018)
  • メトホルミンはKDM2A依存的なrRNA転写抑制及び細胞増殖抑制を引き起こす
    (2018分子生物学会年会 2018)
  • メトホルミンは細胞内コハク酸量を減少させ、KDM2A依存的なrRNA転写抑制を誘導する
    (第5回リボソームミーティング 2018)
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Education (3)：
  • - 2000 The University of Tokyo
  • - 1998 The University of Tokyo
  • - 1996 The University of Tokyo Faculty of Education
Professional career (1)：
  • Ph. D (The University of Tokyo)
Work history (8)：
  • 2019/04 - 現在 Gunma University Graduate School of Medicine, Educational and Research Support Center Associate Professor
  • 2016/01 - 2019/03 Gunma University Initiative for Advanced Research
  • 2015/04 - 2015/12 Gunma University Graduate School of Medicine
  • 2012/08 - 2015/03 コーネル大学 メディカルカレッジ 血管生物学センター インストラクター
  • 2009/08 - 2012/07 Cornell University Weill Medical College
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Awards (1)：
  • 2011/10 - North American Vascular Biology Organization NAVBO annual meeting 2011 Poster Award
Association Membership(s) (3)：
日本脂質生化学研究会 ,  日本生化学会 ,  日本分子生物学会
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