Rchr
J-GLOBAL ID：200901067489536663
Update date: Apr. 19, 2024
Oshima Masanobu
Oshima Masanobu
Homepage URL (1)：
http://genetics.w3.kanazawa-u.ac.jp
Research keywords (3)：
mouse model
, genetics
, inflammation and cancer
Research theme for competitive and other funds (36)：
- 2022 - 2026 Ligand-dependent Wnt activation in malignant progression of gastric cancer
- 2023 - 2025 Negative selection for cancer evolution towards malignancy
- 2023 - 2025 Study on fibrotic niche generation for promotion of gastrointestinal cancer metastasis
- 2021 - 2023 大腸がんの転移・再発を促進する膜タンパク質因子の機能解明と治療応用
- 2021 - 2023 ヒト大腸がんポリクローナル転移機構に関する研究開発
- 2020 - 2023 大腸がん微小転移巣形成機構の理解による新規予防治療戦略の確立
- 2018 - 2022 大腸がんの遺伝的多様性が促進する集団的悪性化機構の研究
- 2019 - 2021 Regulation of colon cancer suppression and malignant progression by TGF-beta signaling
- 2020 - 2021 Mechanisms of colon cancer development by Interleukin-11-producing cancer-associated stromal cells
- 2018 - 2020 新規モデル開発による胃がん微小環境形成と悪性化機構の研究
- 2017 - 2020 大腸がん細胞の多段階悪性化が制御する微小環境ネットワーク機構の解明と新規予防治療戦略の確立
- 2017 - 2019 大腸がんの多段階発がんプロセスにおける細胞競合システムの制御機構
- 2015 - 2018 大腸がん自然転移・再発モデルの開発による悪性化進展機構の研究
- 2012 - 2018 消化器がんの発生・進展過程における慢性炎症の誘導と役割の解明
- 2010 - 2016 Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors
- 2012 - 2015 A novel prevention method for re-obstruction using titanium alloy stent with ultrasonic irradiation
- 2011 - 2015 Role of functional change of microglia in neuropathogenesis of prion diseases
- 2012 - 2015 炎症性微小環境の誘導機序および腫瘍免疫制御機序の研究
- 2010 - 2015 上皮細胞腫瘍化と炎症反応の相互作用による消化管発がん機序
- 2011 - 2014 Physiological and pathological roles of PYND, an anti-inflammatory NLR protein
- 2010 - 2014 疾患モデル動物を用いた環境発がん初期過程の分子機構および感受性要因の解明とその臨床応用に関する研究
- 2009 - 2012 COX-2/PGE2経路と炎症反応による胃がん発生促進機序の研究
- 2009 - 2011 スフェロイドを用いた胃上皮幹細胞の維持に作用するWnt標的分子の探索
- 2008 - 2010 Wnt亢進とBMP抑制の相互作用による胃がん発生機序の研究
- 2007 - 2010 Inflammatory host responses in gastrointestinal tumorigenesis
- 2007 - 2009 胃発癌過程でのPGE2によるWntシグナル活性化へ及ぼす影響の解明
- 2006 - 2009 Elucidation of the mechanism on the formation of early pathological lesion of prion diseases
- 2005 - 2009 Epitehial-stromal interactions and molecularly targeted therapy
- 2006 - 2008 WntおよびBMPシグナルの相互作用による胃粘膜上皮分化制御機構
- 2007 - 2008 Bone marrow derived cells may play an important role in "gastriccancer stem cell system".
- 2005 - 2007 胃癌発生におけるWntシグナル亢進とCOX-2発現誘導の相互作用
- 2005 - 2007 Cooperation of Wnt signaling and COX-2 pathwa in gastrointeitinal tumorigenesis
- 2002 - 2006 消化器癌の転移機構とその治療の研究
- 2003 - 2005 上皮細胞の分化増殖におけるCOX-2とmPGESの作用の解明
- 2000 - 2004 Epithelium-stroma interactions in carcinogenesis
- 2001 - 2003 時期特異的な全身性遺伝子発現誘導トランスジェニックマウスシステムの開発
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Papers (161)：
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Yukinori Ikeda, Jun-ichi Suehiro, Hiroko Oshima, Sau Yee Kok, Kazuki Takahashi, Hiroyuki Sakurai, Tetsuro Watabe, Masanobu Oshima, Yukiko T. Matsunaga. Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters. bioRxiv. 2024
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Yukinori Ikeda, Hiroko Oshima, Sau Yee Kok, Masanobu Oshima, Yukiko T. Matsunaga. Spatiotemporal observation reveals metastatic tumor-driven vascular remodeling as a potential route to polyclonal colonization. 2024
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Atsushi Goto, Ken Ohashi, Mitsuhiko Noda, Hiroshi Noto, Kohjiro Ueki, Manami Inoue, Rimei Nishimura, Shin Takahashi, Tatsuya Ioka, Masanobu Oshima, et al. Third Report of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer: Summary of the results of a questionnaire survey of oncologists and diabetologists-Secondary publication. Cancer Science. 2024. 115. 2. 672-681
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Atsushi Goto, Ken Ohashi, Mitsuhiko Noda, Hiroshi Noto, Kohjiro Ueki, Manami Inoue, Rimei Nishimura, Shin Takahashi, Tatsuya Ioka, Masanobu Oshima, et al. Third Report of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer: Summary of the results of a questionnaire survey of oncologists and diabetologists-Secondary publication. Cancer science. 2024. 115. 2. 672-681
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Kaori Yoshimura, Yukinobu Ito, Mina Suzuki, Masafumi Horie, Takumi Nishiuchi, Yukako Shintani-Domoto, Kazuyoshi Shigehara, Hiroko Oshima, Masanobu Oshima, Akiteru Goto, et al. Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry. Pathology international. 2024
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MISC (78)：
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Hiroki Sato, Ryu Imamura, Katsuya Sakai, Hiroko Oshima, Masanobu Oshima, Kazuhiro Murakami, Yumi Terakado, Yukinari Kato, Seiji Yano, Kunio Matsumoto. Roles of Mature HGF in Gastric Tissue Regeneration and Tumorigenesis. CANCER SCIENCE. 2021. 112. 422-422
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大木 理恵子, 大塚 旬子, 大島 浩子, 安部 良, 大島 正伸. がん抑制遺伝子p53機能喪失とがん微小環境は協調的に胃がん悪性化を促進する(Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers). 日本癌学会総会記事. 2018. 77回. 1074-1074
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寺門 侑美, 村上 和弘, 大島 正伸, 大島 浩子, Nick Barker. 胃がん幹細胞の検討とその制御機構(Analysis of gastric cancer stem cells and regulatory mechanism). 日本癌学会総会記事. 2018. 77回. 2098-2098
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中山 瑞穂, 坂井 絵梨, 越前 佳奈恵, 大島 浩子, Han Tae-Su, 大木 理恵子, 落合 淳志, Voon Dominic, 武藤 誠, 大島 正伸. 核局在した変異型p53は、大腸がん腺管構造変化を伴う悪性化浸潤・転移を誘導する. 日本癌学会総会記事. 2016. 75回. P-1262
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Macrophages in cancer development and progression. 2016. 258. 1. 35-40
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Patents (1)：
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Organoid with metastatic property and use thereof
Lectures and oral presentations (37)：
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Genotype-linked progression and metastasis mechanism of intestinal tumors
(The 113th Annual Meeting of the Japanese Society of Pathology 2024)
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Cluster migration and polyclonal metastasis of intestinal tumor cells
(Duke-NUS/NCCS & Kanazawa University CRI Joint Symposium 2024)
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Collective migration and polyclonal metastasis mechanism.
(Seoul International Gastric Cancer Forum 2023 2023)
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Organoid experiments to understand the metastasis mechanism.
(5th National Cancer Center (NCC)-GCSP Inter-Academy Cancer Symposium 2023)
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Inflammatory microenvironment in intestinal tumorigenesis and progression
(15th In vivo symposium 2023)
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Works (6)：
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Evaluation of combination therapy of docetaxel and aurora kinase inhibitor against gastric cancer
2008 -
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Anti-tumor effect of EP4 antagonist against gastric tumorigenesis
2008 -
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Evaluation of K19-Nog/C2mE transgenic mice as human gastric cancer model
2007 -
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Gene pfofiling analysis using gastric cancer mouse model
2006 -
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Cardioprotective effect by gravity-induced COX-2
2005 -
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Education (4)：
- - 1988 Hokkaido University
- - 1988 Hokkaido University Graduate School, Division of Veterinary Medicine
- - 1986 Hokkaido University School of Veterinary Medicine Veterinary Medicine
- - 1986 Hokkaido University Faculty of Veterinary Medicine
Work history (3)：
- 2013/04 - 2017/03 Kanazawa University Cancer Research Institute Director
- 2013/04 - 2017/03 Kanazawa University Cancer Research Institute
- 1997/03 - 1999/03 Merck Research Laboratories 博士研究員
Committee career (2)：
- 2020/01 - 現在 理事
- 2004 - 2005 : 日本獣医学会 評議員
Awards (1)：
- 2020/05 - ITCクラブ 第43回 石川テレビ賞 ピロリ菌感染による胃がん発生機構の研究
Association Membership(s) (7)：
日本実験動物学会
, 日本生化学会
, 日本分子生物学会
, 日本獣医学会
, 米国癌学会
, 日本癌学会
, American Association of Cancer Research
