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J-GLOBAL ID：200901067489536663   Update date: Nov. 16, 2024

Oshima Masanobu

Oshima Masanobu
Homepage URL  (1)： http://genetics.w3.kanazawa-u.ac.jp
Research keywords  (3)： mouse model ,  genetics ,  inflammation and cancer
Research theme for competitive and other funds  (36)：
  • 2022 - 2026 Ligand-dependent Wnt activation in malignant progression of gastric cancer
  • 2023 - 2025 Negative selection for cancer evolution towards malignancy
  • 2023 - 2025 Study on fibrotic niche generation for promotion of gastrointestinal cancer metastasis
  • 2021 - 2023 大腸がんの転移・再発を促進する膜タンパク質因子の機能解明と治療応用
  • 2021 - 2023 ヒト大腸がんポリクローナル転移機構に関する研究開発
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Papers (170)：
  • Hiroshi Kotani, Hiroko Oshima, Justin C Boucher, Tomoyoshi Yamano, Hiroyuki Sakaguchi, Shigeki Sato, Koji Fukuda, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, et al. Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage. Journal of biomedical science. 2024. 31. 1. 68-68
  • Dong Wang, Emily Woodcock, Xi Yang, Hiromi Nishikawa, Elena V. Sviderskaya, Masanobu Oshima, Christopher Edwards, Yanjun Zhang, Yuri Korchev. Exploration of individual colorectal cancer cell responses to H2O2 eustress using hopping probe scanning ion conductance microscopy. Science Bulletin. 2024. 69. 12. 1909-1919
  • Masahiro Hashimoto, Yasuhiro Kojima, Takeharu Sakamoto, Yuki Ozato, Yusuke Nakano, Tadashi Abe, Kiyotaka Hosoda, Hideyuki Saito, Satoshi Higuchi, Yuichi Hisamatsu, et al. Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis. EBioMedicine. 2024. 103. 105102-105102
  • Yukinori Ikeda, Jun-ichi Suehiro, Hiroko Oshima, Sau Yee Kok, Kazuki Takahashi, Hiroyuki Sakurai, Tetsuro Watabe, Masanobu Oshima, Yukiko T. Matsunaga. Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters. bioRxiv. 2024
  • Yukinori Ikeda, Hiroko Oshima, Sau Yee Kok, Masanobu Oshima, Yukiko T. Matsunaga. Spatiotemporal observation reveals metastatic tumor-driven vascular remodeling as a potential route to polyclonal colonization. 2024
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MISC (80)：
  • Hiroki Sato, Ryu Imamura, Katsuya Sakai, Hiroko Oshima, Masanobu Oshima, Kazuhiro Murakami, Yumi Terakado, Yukinari Kato, Seiji Yano, Kunio Matsumoto. Roles of Mature HGF in Gastric Tissue Regeneration and Tumorigenesis. CANCER SCIENCE. 2021. 112. 422-422
  • 大木 理恵子, 大塚 旬子, 大島 浩子, 安部 良, 大島 正伸. がん抑制遺伝子p53機能喪失とがん微小環境は協調的に胃がん悪性化を促進する(Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers). 日本癌学会総会記事. 2018. 77回. 1074-1074
  • 寺門 侑美, 村上 和弘, 大島 正伸, 大島 浩子, Nick Barker. 胃がん幹細胞の検討とその制御機構(Analysis of gastric cancer stem cells and regulatory mechanism). 日本癌学会総会記事. 2018. 77回. 2098-2098
  • Donghui Cao, Jing Jiang, Dan Zhao, Menghui Wu, Houjun Zhang, Tianyu Zhou, Tetsuya Tsukamoto, Masanobu Oshima, Quan Wang, Xueyuan Cao. The protective effects of 18β-glycyrrhetinic acid against inflammation microenvironment in gastric tumorigenesis targeting PGE2-EP2 receptor-mediated arachidonic acid pathway. European Journal of Inflammation. 2018. 16
  • 大塚 旬子, 江澤 一生, 安部 良, 大島 正伸, 大木 理恵子. がん抑制遺伝子p53機能喪失を伴った胃がんモデルを用いた胃がんの悪性化機構の解明. 日本癌学会総会記事. 2017. 76回. P-1110
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Patents (1)：
  • Organoid with metastatic property and use thereof
Lectures and oral presentations  (37)：
  • Genotype-linked progression and metastasis mechanism of intestinal tumors
    (The 113th Annual Meeting of the Japanese Society of Pathology 2024)
  • Cluster migration and polyclonal metastasis of intestinal tumor cells
    (Duke-NUS/NCCS & Kanazawa University CRI Joint Symposium 2024)
  • Collective migration and polyclonal metastasis mechanism.
    (Seoul International Gastric Cancer Forum 2023 2023)
  • Organoid experiments to understand the metastasis mechanism.
    (5th National Cancer Center (NCC)-GCSP Inter-Academy Cancer Symposium 2023)
  • Inflammatory microenvironment in intestinal tumorigenesis and progression
    (15th In vivo symposium 2023)
ｍore...
Works (6)：
  • Evaluation of combination therapy of docetaxel and aurora kinase inhibitor against gastric cancer
    2008 -
  • Anti-tumor effect of EP4 antagonist against gastric tumorigenesis
    2008 -
  • Evaluation of K19-Nog/C2mE transgenic mice as human gastric cancer model
    2007 -
  • Gene pfofiling analysis using gastric cancer mouse model
    2006 -
  • Cardioprotective effect by gravity-induced COX-2
    2005 -
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Education (4)：
  • - 1988 Hokkaido University
  • - 1988 Hokkaido University Graduate School, Division of Veterinary Medicine
  • - 1986 Hokkaido University School of Veterinary Medicine Veterinary Medicine
  • - 1986 Hokkaido University Faculty of Veterinary Medicine
Work history (3)：
  • 2013/04 - 2017/03 Kanazawa University Cancer Research Institute Director
  • 2013/04 - 2017/03 Kanazawa University Cancer Research Institute
  • 1997/03 - 1999/03 Merck Research Laboratories 博士研究員
Committee career (2)：
  • 2020/01 - 現在 理事
  • 2004 - 2005 : 日本獣医学会 評議員
Awards (1)：
  • 2020/05 - ITCクラブ 第43回 石川テレビ賞 ピロリ菌感染による胃がん発生機構の研究
Association Membership(s) (7)：
日本実験動物学会 ,  日本生化学会 ,  日本分子生物学会 ,  日本獣医学会 ,  米国癌学会 ,  日本癌学会 ,  American Association of Cancer Research
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