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J-GLOBAL ID:200901067514808053   Update date: Feb. 01, 2024

Kimura Motoko

キムラ モトコ | Kimura Motoko
Affiliation and department:
Job title: Chiba University
Homepage URL  (1): http://www.m.chiba-u.jp/dept/experimental-immunology/
Research field  (1): Immunology
Research keywords  (2): 免疫学 Immunology 細胞生物学 Cell Biology 分子生物学 Molecular Biology ,  Immunology Cell Biology Molecular Biology
Research theme for competitive and other funds  (29):
  • 2022 - 2027 Self-referential immune perception
  • 2022 - 2027 Mechanisms of immune homeostasis and responses based on T cell mediated self-recognition
  • 2022 - 2025 膠芽腫微小環境の理解に基づくNKT細胞標的治療の開発
  • 2021 - 2025 早期ライフステージ特異的に産生されるNeonatal T細胞の胸腺内分化機構の解明とその長期モニタリングによる機能解析
  • 2020 - 2023 Detection of the activity of chronic inflammation in subcutaneous tissue by blood sampling and visualization of the process of tissue fibrosis
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Papers (71):
  • Toshio Kanno, Keisuke Miyako, Takeru Endo, Satoru Yokoyama, Hikari K Asou, Kazuko Yamada, Osamu Ohara, Toshinori Nakayama, Motoko Y Kimura, Yusuke Endo. ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development. International immunology. 2023
  • Atsushi Onodera, Kota Kokubo, Mikiko Okano, Miki Onoue, Masahiro Kiuchi, Chiaki Iwamura, Tomohisa Iinuma, Motoko Y. Kimura, Nobuyuki Ebihara, Toyoyuki Hanazawa, et al. Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacology & Therapeutics. 2023. 247. 108445-108445
  • Ryo Koyama-Nasu, Motoko Y Kimura, Masahiro Kiuchi, Ami Aoki, Yangsong Wang, Yukiyoshi Mita, Ichita Hasegawa, Yukihiro Endo, Atsushi Onodera, Kiyoshi Hirahara, et al. CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes. Cancer immunology research. 2023
  • Chiaki Iwamura, Kiyoshi Hirahara, Masahiro Kiuchi, Sanae Ikehara, Kazuhiko Azuma, Tadanaga Shimada, Sachiko Kuriyama, Syota Ohki, Emiri Yamamoto, Yosuke Inaba, et al. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 33. e2203437119
  • Shinsuke Akita, Yuzuru Ikehara, Minami Arai, Hideki Tokumoto, Yoshihisa Yamaji, Kazuhiko Azuma, Yoshitaka Kubota, Hideaki Haneishi, Motoko Y. Kimura, Nobuyuki Mitsukawa. Clinical and Histological Effects of Partial Blood Flow Impairment in Vascularized Lymph Node Transfer. Journal of Clinical Medicine. 2022. 11. 14
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MISC (38):
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Patents (1):
Books (4):
  • T細胞性免疫のエフェクタ-機能のメカニズム 生体防御におけるT細胞の機能 基礎免疫学 原著第6版ー免疫系の機能とその異常
    2020
  • 分子細胞免疫学 原著第9版
    エルゼビア・ジャパン 2018 ISBN:9784860349172
  • Memory Th1/Th2 cell generation controlled Schnurri-2. Memory T-cells
    2009
  • TCR-mediated signaling events required for T helper subset differentiation. in kinases and phosphatases in lymphocyte and neuronal signaling
    1997
Lectures and oral presentations  (96):
  • CD69-Myl9 system and inflammation
    (2021)
  • CD69 Biology and Pathology
    (11th International Symposium of IFReC, Immunology at the Forefront 2020)
  • Identification of a novel transcription factor that negatively regulates Interleukin-9 production in Th9 cells.
    (The 48th Annual Meeting of The Japanese Society for Immunology)
  • CD69 regulates T cell exhaustion at the tumor microenvironment
    (First Chiba University - University of Toronto workshop 2019)
  • Inhibition of acetyl-CoA carboxylase enhances memory Th2 cell generation and Th2 mediated anti-tumor immunity
    (2019)
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Professional career (1):
  • Doctor (Chiba University)
Work history (7):
  • 2021/04 - 現在 Chiba University
  • 2016/01 - 2021/03 Chiba University Graduate School of Medicine
  • 2014/01 - 2015/12 Chiba University
  • 2011/04 - 2013/12 National Cancer Institue/ NIH
  • 2006/04 - 2011/03 米国 国立癌研究所 Postdoctoral Fellow
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Committee career (3):
  • 2016 - 現在 Kyoto T Cell Conference(KTCC) 運営委員
  • 2016 - 現在 日本免疫学会 評議員
  • 2010 - 2011 米国 国立衛生研究所 Immunology Interest Group (*IIG) Steering Committee A postdoctoral Fellow representative
Awards (3):
  • 2017/06 - 千葉医学会 第9回(2017年度)千葉医学会賞
  • 2016/02 - 第45回日本免疫学会総会・学術集会 ベストプレゼンテーション賞
  • 2002/12 - 第32回日本免疫学会総会・学術集会 Melchers' Travel Award
Association Membership(s) (3):
THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  日本がん免疫学会
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