Rchr
J-GLOBAL ID：200901067910197474
Update date: May. 07, 2024
Harusawa Shinya
ハルサワ シンヤ | Harusawa Shinya
Affiliation and department：
Job title：
Emeritus Professor
Other affiliations (1)：
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大阪薬科大学
大阪薬科大学
教授,教授,教授,教授
Homepage URL (1)：
http://www.oups.ac.jp/supported/koho/lab/seizol.html
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (2)：
有機合成 創薬化学
, Organic Synthesis
Research theme for competitive and other funds (22)：
- 2015 - 2018 Drug discovery research based on dinuclear platinum complexes with markedly high antitumor activity
- 2014 - 2017 Approach toward anti-breast cancer agents using novel histamine H3 antagonists
- 2009 - 2014 Probing the catalytic mechnism of ribozymes and breast cancer inhibitory effects based on imidazole C-nucleosides
- 2009 - 2011 The role of histamine H4 receptor in the development of cancer-related fatigue
- 2004 - 2007 イミダゾールC-ヌクレオシドの合成研究に基づくH4受容体及びRNA触媒機能解明
- 2004 - 2007 Synthetic studies for functional elucidation of RNA catalysis and H4 receptor
- 2003 - 2005 Development of selective ligands to histamine H3 and H4 receptors and its application to elucidate the physiological function of the receptors.
- 2003 - エストラジオール関連化合物の合成研究
- 2003 - イミダゾールのRNA触媒における擬核酸塩基としての役割
- 2003 - Fuctions of imidazole as a pseudo nucleobase in RNA catalysis
- 1999 - 2002 Development and Application of Novel Histamine H_3 agonist Imifuramine
- 2001 - ヒスタミンH4-リガンドの研究
- 1997 - 1999 強力なH_3-アゴニスト活性を持つ新規イミダゾールC-ヌクレオシドの設計と合成
- 1992 - 1993 Sigmatropic Ring Expansion : Quantitative Evaluation of the Transition States and its Synthetic Application to Natural Products
- 1989 - 1989 中員環及び大環状チオノカーボネートを合成中間体とする各種合成反応の開発
- 1984 - 1984 シアノホスフェートを合成中間体とする各種合成反応の開発
- 創薬のための有機化学による基礎研究
- ヒスタミンH3リガンドの創製
- イミダゾールC-ヌクレオシドの合成研究
- The creation of histamine H3 ligands
- Studies on synthesis of imidazole C-nucleosides
- Sigmatropic Rearrangement containing Sulfur atom
Show all
Papers (28)：
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Hiroki Yoneyama, Ayami Okada, Noboru Hayama, Shinya Harusawa, Yoshihide Usami. Transformation of Benzaldehydes to Benzonitriles via Cyanophosphates without One-carbon Homologation. Synthesis (Germany). 2024
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Masako Uemura, Keiichi Hiramoto, Hiroki Yoneyama, Shinya Harusawa, Seiji Komeda. Introduction of Fluorine into Antitumor-Active Dinuclear Platinum(II) Complexes Leads to Modulation of In Vivo Antitumor Activity in Mice. Inorganic chemistry. 2022. 61. 31. 12155-12164
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Yoshihide Usami, Kimika Nakamura, Yoshino Mizobuchi, Koji Mizuki, Shinya Harusawa, Hiroki Yoneyama, Takeshi Yamada. Enantiomeric composition of natural pericosine A derived from Periconia byssoides and alpha-glycosidase inhibitory activity of (-)-enantiomer. CHIRALITY. 2022
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Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Takahiro Tsuchiya, Miyuu Hoshiyama, Tomoya Sakazaki, Keiichi Hiramoto, Shinya Harusawa. Data on synthesis and structure-activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes. Data in brief. 2022. 40. 107697-107697
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Hiroki Yoneyama, Mano Adachi, Aoshi Morita, Maki Nakagawa, Miho Baba, Kanako Yamawaki, Noboru Hayama, Shinya Harusawa, Yoshihide Usami. Synthesis of 5,6-Dihydro-4 H -pyrrolo[1,2- b ]pyrazoles and Homologs from 5-Substituted 2-(Alkynyl)tetrazoles via Microwave-induced Intramolecular Nitrile Imine-Alkyne 1,3-Dipolar Cycloaddition. Synthesis (Germany). 2022. 55. 6. 945-958
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MISC (89)：
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Hiroki Yoneyama, Takuji Magata, Kenji Uemura, Yoshihide Usami, Satoshi Tanaka, Masanori Takaoka, Shinya Harusawa. Erratum: Efficient synthesis of N -[4-(4-chlorophenyl)butyl]- S -(3-piperidinopropyl)isothiourea (OUP-186) and its analogues using 2-nitrophenylacetyl isothiocyanate: Application to novel histamine H<inf>3</inf>R antagonists (Synthesis (German. Synthesis (Germany). 2015. 47
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Shinya Harusawa, Hiroki Yoneyama, Yoshihide Usami, Daisuke Yamamoto, Zheng Yun Zhao. Erratum: Synthesis of C4-Linked C<inf>0</inf>- and C<inf>2</inf>-imidazole 2′-deoxyribonucleoside phosphoramidites and imidazole base-pairing effects on DNA (Synthesis (2014) 46 (2815)). Synthesis (Germany). 2014. 46
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Lisa Araki, Shinya Harusawa. Synthetic Studies of Imidazole C-Nucleosides toward Biofunctional Molecules. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. 2010. 130. 12. 1707-1724
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Hiroki Yoneyama, Ayako Shimoda, Lisa Araki, Kouta Hatano, Yasuhiko Sakamoto, Takushi Kurihara, Atsushi Yamatodani, Shinya Harusawa. Efficient approaches to S-alkyl-N-alkylisothioureas: Syntheses of histamine H3 antagonist clobenpropit and its analogues. JOURNAL OF ORGANIC CHEMISTRY. 2008. 73. 6. 2096-2104
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S Harusawa, K Yoshida, C Kojima, L Araki, T Kurihara. Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage. TETRAHEDRON. 2004. 60. 51. 11911-11922
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Patents (2)：
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Aromatic acetonitrile derivatives.
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Improvement in the production of imidazole derivatives and novel intermediates of the derivatives.
Books (4)：
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有機薬品製造化学 第4版
廣川書店 2004
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Formation of Two 4-Imidazolylmethylphosphonium Salts and Their Synthetic Studies Toward Histamine H3-Ligands
Synthesis 2003
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Histamine Research in the New Millenium
Elsevier 2001
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Histamine Research in the New Millennium
Elsevier 2001
Works (5)：
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Dundee大学David M. J. Lilley教授との共同研究
2003 -
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Improvement in the production of imidazole derivatives and novel intermediates of the derivatives. PCT Patent WO 030/70722
2003 -
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大阪大学医学部保健学科、大和谷厚教授との共同研究
1999 -
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芳香族置換アセトニトリル誘導体の製造法 特許公報(B-2)〔平5-33216〕
1993 -
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芳香族置換アセトニトリル誘導体の製造法
1984 -
Education (4)：
- - 1982 Nagoya City University
- - 1982 Nagoya City University Graduate School, Division of Pharmaceutical Sciences
- - 1977 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Department of Pharmacy
- - 1977 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Science
Professional career (1)：
Awards (1)：
Association Membership(s) (1)：
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