Fujita Kaori

フジタカオリ | Fujita Kaori

Affiliation and department：

Research field (2)： Cell biology , Molecular biology

Research keywords (8)： Aging , Cellular Senescence , p53 isoform , p53 , 細胞生物学 , 分子生物学 , cell biology , molecular biology

Research theme for competitive and other funds (3)：

2018 - 2022 Mechanism of chondorogenic differentiation from aged mesencymal stem cells by overexpression of delta133p53
2013 - 2017 細胞老化を克服した軟骨細胞分化誘導/維持メカニズムの解析
2014 - 2016 二次元培養下での脱分化軟骨細胞の再分化促進因子/低分子化合物の網羅的探索

Papers (24)：

Tomonori Ozaki, Tatsuya Kawamoto, Yuki Iimori, Nobuaki Takeshita, Yukiko Yamagishi, Hiroaki Nakamura, Masazumi Kamohara, Kaori Fujita, Masayuki Tanahashi, Noriyuki Tsumaki. Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia. Scientific Reports. 2020. 10. 1. 20915-20915
Kaori Fujita. p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions. International Journal of Molecular Sciences. 2019. 20. 23. 6023-6023
Kosai A, Horike N, Takei Y, Yamashita A, Fujita K, Kamatani T, Tsumaki N. Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation. Biochem Biophys Res Commun. 2019. 516. 4. 1097-1102
Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N. Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia. Osteoarthritis and Cartilage. 2018. 26. 11. 1551-1561
木村武司, 尾崎友則, 藤田香里, 山下晃弘, 森岡美穂, 大薗恵一, 妻木範行. 骨代謝と病気の新たなクロストーク:臓器連関から創薬まで疾患特異的ヒトiPS細胞を用いた成長板軟骨モデルの確立と創薬への応用. 日本骨代謝学会学術集会プログラム抄録集. 2018. 36回. 115-115

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MISC (7)：

Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 (vol 7, 10959, 2016). NATURE COMMUNICATIONS. 2016. 7
山下晃弘, 森岡美帆, 岸宏美, 木村武司, 箭原康人, 岡田稔, 藤田香里, 澤井英明, 池川志郎, 妻木範行. スタチンによるFGFR3軟骨形成異常症の病態回復. 日本軟骨代謝学会プログラム・抄録集. 2016. 29th
Izumi Horikawa, Kaori Fujita, Lisa Miller Jenkins, Yukiharu Hiyoshi, Abdul M. Mondal, Borivoj Vojtesek, David P. Lane, Ettore Appella, Curtis C. Harris. Autophagic degradation of Delta 133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53. CANCER RESEARCH. 2013. 73
Abdul Matin Mondal, Lzumi Horikawa, Sharon R. Pine, Kaori Fujita, Borivoj Vojtesek, Jean-Christophe Bourdon, Elsa Vera, David P. Lane, Maria A. Blasco, Curtis C. Harris. p53 isoforms, Delta 133p53 and p53 beta, regulate aging-associated T lymphocyte senescence. CANCER RESEARCH. 2011. 71
Izumi Horikawa, Kaori Fujita, Curtis C. Harris. p53 governs telomere regulation feedback too, via TRF2. AGING-US. 2011. 3. 1. 26-32

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Patents (2)：

Manipulation of stem cell function by p53
Therapeutic application of p53 isoforms in regenerative medicine, aging and cancer

Education (2)：

Professional career (1)：

Work history (8)：

2021/04 - 現在 Faculty and Graduate School of Engineering Science, Akita University Department of Life Science
2016/04 - 2021/03 Center for iPS Cell Research and Application, Kyoto University Department of Clinical Application
2012/01 - 2016/03 Center for iPS Cell Research and Application, Kyoto University Dept. of Cell Growth and Differentiation Researcher
2010/01 - 2012/01 National Cancer Institute, National Institutes of Health Lab. of Human Carcinogenesis Research Fellow
2005/02 - 2010/01 National Cancer Institute, National Institutes of Health Lab. of Human Carcinogenesis Visiting Fellow

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Committee career (2)：

Association Membership(s) (3)：

日本癌学会 , 日本分子生物学会 , International Cell Senescence Association

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