Takagi Norio

タカギノリオ | Takagi Norio

Affiliation and department：
Job title： Professor

Research field (3)： Pharmacology , Pharmaceuticals - health and biochemistry , Neuroscience - general

Research keywords (8)：脳血管障害 , 脳虚血 , 脳卒中 , 神経幹細胞 , 神経変性 , 神経保護 , 神経薬理学・神経化学 , Glutamate receptor

Research theme for competitive and other funds (22)：

2022 - 2025 6年制導入に伴う薬学教育のジレンマとその解消策-東薬の経験と他大学の比較-
2017 - 2019 脳梗塞における神経細胞のLRP1機能変化と治療戦略
2014 - 2017 Fundamental research of application of arsenic compound in combination with tetrandrine to combat breast cancer
2015 - 2017 生理活性ガスを含有する超音波応答性ナノバブルの開発と疾患治療システムの構築
2013 - 2016 Ultrasound-mediated gene delivery system into brain tissue by blood brain barrier targeting Bubble liposomes

2012 - 2014 神経前駆細胞を基盤とした脳梗塞後のうつ様・不安様症状の病態解析と治療戦略

2011 - 2013 モルフォリノオリゴ搭載ナノバブルと超音波による筋ジストロフィーの革新的治療戦略

2011 - 2013 Protein tyrosine phosphorylation in the neurovascular unit in cerebrovascular disease and therapeutic strategies

2011 - 2012 症例コンテンツの知識情報を活用した地域介護支援システムの研究開発

2010 - 2012 Gene transfer system into mesenchymal stem cell by peptide-modified liposomes and ultrasound technology

2008 - 2010 Molecular basis of cerebrovascular disease with protein tyrosine phosphorylation in brain capillaries and therapeutic strategies

2008 - 2010 Low invasive therapeutic system for vascular diseases by neovascular specific liposomes containing US-contrast gas

2006 - 2007 新規な超音波造影ガス封入リポソームによる非侵襲的虚血性血管再生療法のシステム開発

2007 - 脳梗塞後の脳血管NADPH oxidaseサブユニットのリン酸化と酸化ストレスに関する研究

2005 - 2006 脳梗塞病態の分子基盤としてのNMDA受容体チロシンリン酸化とその制御に関する研究

2003 - 2004 代謝型グルタミン酸受容体を介する脳虚血後のNMDA受容体チロシンリン酸化の研究

2000 - 2001 脳虚血後のNMDA受容体チロシンリン酸化と細胞内情報伝達に関する研究

2001 - 一過性局所脳虚血後のN-methyl-D-aspartate (NMDA)受容体のチロシンリン酸化とタンパク質相互作用に関する研

1999 - 2000 STUDIES ON REGENERATION OF THE NEURONAL NETWORK IN CEREBROVASCULAR DEMENTIA MODEL

2000 - The role of tyrosine phosphorylation of NMDA receptor subunit NR2A and NR2B in the hippocampus following transient global ischemi

Pharmacological and Biochemical study on cerebral ischemia

The role of tyrosine phosphorylation of the NMDA receptor after brain ischemia

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Papers (153)：

Yui Iwatani, Hideki Hayashi, Haruno Oba, Maho Oba, Ann Sawamura, Yoshiyuki Moriyama, Norio Takagi. Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a/LC3 pathway. Biomedicine & Pharmacotherapy. 2024. 176. 116778-116778
Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jun-guo Ren, Jian-xun Liu, Norio Takagi. Role of senkyunolide I in the promotion of neural stem/progenitor cell proliferation via the Akt/β-catenin pathway. Biomedicine & Pharmacotherapy. 2023. 168. 115683-115683
Yui Iwatani, Hideki Hayashi, Haruna Yamamoto, Hayato Minamikawa, Mitsuki Ichikawa, Hayato Orikawa, Aya Masuda, Natsumi Tada, Yoshiyuki Moriyama, Norio Takagi. Pathogenic role of NAMPT in the perivascular regions after ischemic stroke in mice with type 2 diabetes mellitus. Experimental neurology. 2023. 114584-114584
Bo Yuan, Hidetomo Kikuchi, Jingmei Li, Atsushi Kawabata, Kozo Yao, Norio Takagi, Mari Okazaki. Cytotoxic Effects of Darinaparsin, a Novel Organic Arsenical, against Human Leukemia Cells. International Journal of Molecular Sciences. 2023. 24. 3. 2282-2282
Ichiro Horinokita, Hideki Hayashi, Takamasa Nagatomo, Yuna Fushiki, Yui Iwatani, Norio Takagi. Effect of Progranulin on Proliferation and Differentiation of Neural Stem/Progenitor Cells after Oxygen/Glucose Deprivation. International journal of molecular sciences. 2022. 23. 4

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MISC (135)：

袁博, 菊地秀与, 高木教夫, 岡崎真理. 微量元素研究領域の最前線:生理機能の解明と創薬研究ヒ素化合物の臨床応用および抗腫瘍活性メカニズム. Biomedical Research on Trace Elements. 2021. 32. 2. 60-60
袁博, 高木教夫, 岡崎真理, 平野俊彦. 元素の力で切り拓く次世代の低分子創薬〜重水素から高周期元素までヒ素化合物の抗腫瘍活性およびその新規臨床応用の可能性(Anti-tumor activity of arsenic compounds and its potential novel application in clincs). 日本薬学会年会要旨集. 2021. 141年会. S11-5
BO Yuan, 菊地秀与, 高木教夫, 岡崎真理. Clinical application of arsenic compounds and the mechanisms underlying their anti-tumor activity. Biomedical Research on Trace Elements (Web). 2021. 32. 2
林秀樹, 森みすず, 見世加南子, YUAN Bo, 高木教夫. Neuroprotective roles of low density lipoprotein-receptor related protein 1 with reduction of alpha 2-macroglobulin in the retina. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
Asada Mayumi, Hayashi Hideki, Murakami Kenjiro, Kikuiri Kento, Kaneko Ryotaro, Yuan Bo, Takagi Norio. Roles of DNA methylation in neuronal cell death after ischemic injury. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 1-O-C1-3

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Books (3)：

Education (2)：

- 1996 Tokyo University of Pharmacy and Life Sciences Graduate School of Pharmacy
- 1991 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy

Professional career (1)：

Work history (5)：

Committee career (2)：

Awards (2)：

Association Membership(s) (6)：

北米神経科学会(Society for Neuroscience) , 日本循環薬理学会 , 日本神経化学会 , 日本薬理学会 , 日本薬学会 , 国際脳循環代謝学会(International Society for Cerebral Blood Flow&Metabolism)

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