Rchr
J-GLOBAL ID：200901068509075370   Update date: Mar. 13, 2025

Shima Midori

シマ ミドリ | Shima Midori
Affiliation and department：
Nara Medical University

About Nara Medical University


Job title： Associate Professor
Research field  (2)： Fetal medicine/Pediatrics ,  Hematology and oncology
Research keywords  (8)： セリンプロテアーゼ ,  第VIII因子 ,  血友病 ,  血液凝固 ,  Serine protease ,  Factor VIII ,  Hemophilia ,  Blood coagulation
Research theme for competitive and other funds  (27)：
  • 2020 - 2024 Development of Universal Cell Therapy for Hemophilia A 
  • 2019 - 2022 Establishment of the novel tailored therapy for the thrombosis of pediatric cancer based on the balance between coagulation and fibrinolysis
  • 2017 - 2020 Studies on molecular pathology of hemophilia A and gain-of-function of FVIII
  • 2013 - 2016 Establishment of the next generation treatment for hemophilia A by autologous cell implantation
  • 2013 - 2015 血友病インヒビター保有例に対する免疫寛容療法の実態に関する調査研究
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Papers (416)：
  • Asuka Sakata, Kohei Tatsumi, Naoki Matsumoto, Nigel Mackman, Suguru Harada, Ryohei Kawasaki, Yukiko Okuyama-Nishida, Tetsuhiro Soeda, Keiji Nogami, Midori Shima. Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model. Communications biology. 2025. 8. 1. 390-390
  • Seiji Mitani, Chihiro Hosoda, Yu Onodera, Yoko Takabayashi, Asuka Sakata, Midori Shima, Kohei Tatsumi. Efficient generation of liver sinusoidal endothelial-like cells secreting coagulation factor VIII from human induced pluripotent stem cells. Molecular therapy. Methods & clinical development. 2024. 32. 4. 101355-101355
  • Ryohei Kawasaki, Asuka Sakata, Kohei Tatsumi, Seiji Mitani, Maiko Takeda, Shogo Kasuda, Naoki Matsumoto, Suguru Harada, Tetsuhiro Soeda, Yukiko Nishida, et al. β-hydroxybutyrate suppresses pathological changes of blood-induced arthropathy in rats. Scientific reports. 2024. 14. 1. 29696-29696
  • Midori Shima, Nobuaki Suzuki, Hidekazu Nishikii, Kagehiro Amano, Yoshiyuki Ogawa, Ryota Kobayashi, Ryoto Ozaki, Koichiro Yoneyama, Narumi Mizuno, Emiko Sakaida, et al. Final Analysis Results from the AGEHA Study: Emicizumab Prophylaxis for Acquired Hemophilia A with or without Immunosuppressive Therapy. Thrombosis and haemostasis. 2024
  • Chihiro Hosoda, Seiji Mitani, Asuka Sakata, Shogo Kasuda, Yu Onodera, Yoko Takabayashi, Midori Shima, Kohei Tatsumi. MEK inhibitor PD0325901 upregulates CD34 expression in endothelial cells via inhibition of ERK phosphorylation. Regenerative therapy. 2024. 26. 654-662
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MISC (997)：
  • Kuniyoshi Mizumachi, Yuto Nakajima, Naruto Shimonishi, Shoko Furukawa, Kenichi Ogiwara, Masahiro Takeyama, Midori Shima, Keiji Nogami. Escaping Ability of Human-Porcine Hybrid Factor VIII from Anti-Factor VIII Inhibitors with an A2 or C2 Epitope. BLOOD. 2022. 140. 8430-8431
  • Yuto Nakajima, Kenichi Ogiwara, Takehisa Kitazawa, Midori Shima, Keiji Nogami. Activated Protein C-Catalyzed Inactivation Pathway Down-Regulates NXT007-Mediated Hemostatic Function. BLOOD. 2022. 140. 5576-5577
  • Yuto Nakajima, Kuniyoshi Mizumachi, Naruto Shimonishi, Shoko Furukawa, Kenichi Ogiwara, Masahiro Takeyama, Midori Shima, Keiji Nogami. Global Coagulation Potentials and Breakthrough Bleeds in Emicizumab-Treated Hemophilia a Patients Were Similar to Mild Hemophilia a Patients. BLOOD. 2021. 138
  • Yuto Nakajima, Keiji Nogami, Hiroaki Minami, Kana Sasai, Midori Shima. Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Novel Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg(1689). BLOOD. 2019. 134
  • 榊原 崇文, 嶋 緑倫. 【妊娠と精神科薬物療法】精神科薬と子どもの発育・発達. 精神科. 2019. 35. 2. 168-173
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Patents (10)：
  • 凝固因子インヒビター力価の測定方法
  • 血液検体の凝固特性の評価方法
  • 血液凝固第VIII因子(FVIII)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第IX因子(FIX)異常症の予防および/または治療に用いられる医薬組成物
  • 血友病の重症度の判定方法及び血液検体の分析装置
  • 血液検体の分析方法、血液検体分析用試薬及び試薬キット、並びに血液検体分析装置
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Education (1)：
  • - 1979 Nara Medical University Medical Faculty Medical Department
Professional career (1)：
  • Dotor (Medical) (Nara Medical University)
Work history (25)：
  • 2018 - Nara Medical University
  • 2018 - Nara Medical University
  • 2018 - Nara Medical University
  • 2018 - Nara Medical University
  • 2014 - Nara Medical University
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Committee career (32)：
  • 2018 - 現在 国際血友病学会 血友病ガイドライン委員
  • 2018 - 現在 国際血栓止血学会 プログラム委員
  • 2018 - 現在 国際血栓止血学会 会員委員会
  • 2018 - 現在 国際血栓止血学会 教育委員会
  • 2018 - 現在 国際血栓止血学会 理事
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Awards (6)：
  • 2020/12 - Prime Minister of Japan and His Cabinet The 4th Grand Prize of Japan Medical Research Development
  • 2020/10 - Japan Industry Association 4th Japan Bioindustry Award
  • 2018 - 日本血液学会賞
  • 2016 - 国際血友病学会 Arosenius賞
  • 1993 - 日本血液学会奨励賞
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Association Membership(s) (20)：
JAPANESE SOCIETY OF LABORATORY MEDICINE ,  日本血栓止血学会 ,  小児科学会 ,  日本臨床血液学会 ,  日本血液学会 ,  The Japanese Society of Clinical Pathology ,  The Japanese Society of Thronbosis and Hemostasis ,  The Japanese Society of Pediatrics ,  The Japanese Society of Clinical Hematology ,  The Japanese Society of Hematology ,  world federation of hemophilia ,  the american society of hematology ,  JAPANESE SOCIETY OF PEDIATRIC CARDIOLOGY AND CARDIAC SURGERY ,  THE JAPANESE SOCIETY FOR PEDIATRIC INFECTIOUS DISEASES ,  the japanese society of laboratory hematology ,  JAPAN SOCIETY FOR NEONATAL HEALTH AND DEVELOPMENT ,  The Japanese Society Of Child Neurology ,  the Japan society of obstetrical, gynecological and neonatal hematology ,  the japanese society of pediatoric hematology ,  international society on thrombosis and haemostasis
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