Rchr
J-GLOBAL ID：200901069005201479
Update date: Oct. 29, 2024
SAKURAI Takeshi
サクライ タケシ | SAKURAI Takeshi
Affiliation and department：
Job title：
Professor
Research field (1)：
Physiology
Research theme for competitive and other funds (67)：
- 2022 - 2029 Deciphering the mysteries of sleep:creating a global network of sleep neurobiologists
- 2023 - 2028 冬眠生物学2.0 総括班
- 2023 - 2028 Exploring the Mechanisms of Dormancy and Hibernation
- 2023 - 2026 持久力を高める次世代栄養戦略
- 2021 - 2026 Elucidation and application of neural mechanisms that induce hibernation-like hypometabolic state
- 2021 - 2023 Energy metabolism and disease sensitivity determined by body temperature: Lessons from hibernation
- 2021 - 2023 Elucidation of the mechanism of action of Q-neurons
- 2019 - 2023 Elucidation of molecular mechanism of cognitive dysfunction associated with sepsis and approach to new therapeutic agents
- 2021 - 2022 Elucidation of neural mechanisms that induce hibernation-like states
- 2021 - 2022 Generation and Promotion of Willdynamics
- 2019 - 2021 Identification of neural circuits for induction of torpor and induction of artificial hibernation
- 2018 - 2021 Elucidation of the structural and functional linkage between the limbic system and the sleep-wake control system.
- 2016 - 2021 Elucidation of the molecular and neural basis involved in motivation and behavioral reinforcement
- 2016 - 2021 Creation and Promotion of the Will-Dynamics
- 2016 - 2021 Creation and Promotion of Willdynamics
- 2016 - 2019 Elucidation of molecular mechanism of orexin on the brain in endotoxin shock
- 2016 - 2019 Development of novel orexin ligand and its pharmacological activity
- 2015 - 2018 Analysis of sleep-wake regulatory system by optogenetics featuring cone opsins.
- 2015 - 2018 Neuronal mechanisms that regulate hyper-arousal in response to stress and anxiety
- 2016 - 2017 新規神経ペプチド受容体NPBWR1の機能が共感性において果たす役割
- 2015 - 2017 行動適応にかかわる覚醒システムの機能解明
- 2015 - 2017 Identification of bona fide circadian pacemaker neurons
- 2015 - 2017 Depicting neural circuit that evokes cataplexy
- 2014 - 2016 Activation of brown adipocyte by GDF5-Ifrd1 axis
- 2012 - 2016 Neural mechanisms underlying the circadian pacemakers
- 2010 - 2016 The Epigenomic Analysis of Obesity and Insulin Resistance
- 2010 - 2016 Comprehensive Brain Science Network
- 2012 - 2014 The regulation of energy metabolism by brown-adipokine
- 2011 - 2013 Development of a novel gene therapy on narcolepsy using AAV vectors and artificial GPCRs
- 2011 - 2013 Analyses of the intracellular leptin signaling in leptin resistance and development of a screening system for anti-obese drugs
- 2010 - 2012 Effects of Neuropeptide W, and B on autonomic nervous system
- 2011 - 2011 オレキシンニューロンのコネクトミクスとメタボロミクスによる睡眠・覚醒制御系の解明
- 2008 - 2011 Function of food-entrainable clock neurons in the dorsomedial hypothalamic nucleus
- 2009 - 2010 摂食制御に関わる神経細胞群を制御する生理活性物質の検索
- 2008 - 2010 Elucidate the role of BMP and BMP antagonist USAG-1 in the progression of chronic kidney diseases and therapeutic application
- 2008 - 2010 Physiological roles of the regulatory system of orexin-producing neurons
- 2008 - 2009 Studies of Novel Neuropeptides involved in Regulation of Emotional Reaction and Amygdala Function
- 2007 - 2009 Roles of orexin-producing neurons in awakening from anesthesia : Analyses using various genetically-modified mice
- 2006 - 2009 Roles of orexins in regulation of sleep/wake states
- 2006 - 2008 様々なトランスジェニックマウスを用いた睡眠覚醒制御機構の解析
- 2006 - 2007 トランスジェニック動物を用いたインビボ神経細胞同定法の開発
- 2006 - 2007 桃体機能、情動の制御に関わる新規神経ペプチドの検索とその生理作用の解明
- 2006 - 2007 睡眠覚醒サイクル発現におけるオレキシン神経の役割について
- 2005 - 2007 Mechanisms and physiological roles of regulation of orexin-producing neurons by leptin and TNF-alfa
- 2005 - 2005 扁桃体機能、情動の制御に関わる新規神経ペプチドの検索とその生理作用の解明
- 2004 - 2005 Regulatory role by orexin on the development of anti-gravity muscle and exercise-related functions
- 2003 - 2005 Molecular pharmacological study and development of new treatment by investigating endothelin in cardiovascular diseases.
- 2002 - 2005 The analysis of the mechanisms of sleep/wakefulness and feeding behavior regulated by orexin
- 2002 - 2004 Study of the mechanisms that regulate the activity of orexin-producing neuron.
- 2002 - 2003 Study on Regulatory Mechanisms of Orexin Neuronal Activity that regulate Emotion and Stress Responses
- 2002 - 2003 GRANT-IN-AID FOR SCIENTIFIC RESEARCH (B) (2)
- 2001 - 2002 Identification of the ligands for Cardiac Orphan G protein -Coupled Receptors and Development of T herapy Modulating Cardiac Function
- 2000 - 2002 Regulation by glucose and insulin of the neurons in feeding-regulatory centers and its alteration in obesity and diabetes
- 2000 - 2002 Molecntan biological and pharmaco-physiological approach to pathophysiological roles of endothelin-1 in aggrarating heart failure
- 2000 - 2002 摂食行動に関与する新規神経ペプチド、オレキシンの生理作用に関する研究
- 2001 - 2001 走運動時のストレス反応は脳内のオレキシン作動性機構を介するか?
- 2000 - 2001 Molecular and Developmental Biological Research on Roles of a novel neuropeptide, Orexin
- 1999 - 2001 Molecular pharmacological approach to roles of endothelin in heart failure and deverlopmet of new tehrapeuetin strategy
- 1999 - 2001 Exploration of the novel therapeutic methods for the treatment of chronic circulatory diseases
- 1997 - 1998 アストロサイトに対するプロテインSとGas6の生理作用に関する研究
- 1996 - 1998 The role new pepdidergic neuron in autoregulation of regional blood flow.
- 1995 - 1997 Analysis of dedifferentiation and growth of glial cells in tissue regeneration process after brain damage
- 1996 - 1996 腸管壁在神経細胞の発生過程におけるエンドセリンB受容体の情報伝達系の役割
- 1995 - 1995 アストロサイトが産生する脳毛細血管の分化を促す液性因子の分子クローニング
- 1994 - 1994 エンドセリン受容体の情報伝達系に関する分子生物学的解析
- Molecular Pharmacological Study on Feeding Behavior
- Molecular Pharmacological Study on Sleep-Wake Cycle
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Papers (396)：
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Sawada, Takeshi, Iino, Yusuke, Yoshida, Kensuke, Okazaki, Hitoshi, Nomura, Shinnosuke, Shimizu, Chika, Arima, Tomoki, Juichi, Motoki, Zhou, Siqi, Kurabayashi, Nobuhiro, et al. Prefrontal synaptic regulation of homeostatic sleep pressure revealed through synaptic chemogenetics. Science (New York, N.Y.). 2024. 385. 6716. 1459-1465
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Kashiwagi, Mitsuaki, Beck, Goichi, Kanuka, Mika, Arai, Yoshifumi, Tanaka, Kaeko, Tatsuzawa, Chika, Koga, Yumiko, Saito, Yuki C., Takagi, Marina, Oishi, Yo, et al. A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Cell. 2024
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Masuda, Kosaku, Sakurai, Takeshi, Hirano, Arisa. A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress. Scientific reports. 2024. 14. 1
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Masuda, Kosaku, Sakurai, Takeshi, Hirano, Arisa. A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress. Scientific reports. 2024. 14. 1
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Nakai, Ayaka, Kashiwagi, Mitsuaki, Fujiyama, Tomoyuki, Iwasaki, Kanako, Hirano, Arisa, Funato, Hiromasa, Yanagisawa, Masashi, Sakurai, Takeshi, Hayashi, Yu. Crucial role of TFAP2B in the nervous system for regulating NREM sleep. Molecular brain. 2024. 17. 1. 13
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MISC (69)：
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Koyanagi, Iyo, Wang, Yuteng, Srinivasan, Sakthivel, Yu, Jiahui, Naoi, Toshie, Ohba, Akinobu, Kumar, Deependra, Wu, Pei-Hsi, Matsuda, Shinji, Cherasse, Yoan, et al. Mechanism of hippocampal adult-born neurons for memory consolidation. The Journal of Physiological Sciences. 2022. 72. 33. 151-151
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橋本佳応, 南雲康行, 齊藤夕貴, 斉藤毅, 斉藤毅, 山本直司, 沓村憲樹, 沓村憲樹, 櫻井武, 長瀬博. 体性感覚神経系におけるオレキシン神経の役割. 鎮痛薬・オピオイドペプチドシンポジウムプログラム・抄録集. 2021. 40th
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Zhang Tong, 上居 寛典, 柳田 淳子, 和田 進太郎, 堂本 将輝, 出山 諭司, 宝田 剛志, 檜井 栄一, 崎村 建司, 山中 章弘, et al. コカイン関連記憶の獲得および想起における内側前頭前野グルタミン酸作動性ニューロンの役割. 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2018. 28回・48回. 216-216
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Zhang Tong, 上居 寛典, 柳田 淳子, 和田 進太郎, 堂本 将輝, 出山 諭司, 宝田 剛志, 檜井 栄一, 崎村 建司, 山中 章弘, et al. コカイン関連記憶の獲得および想起における内側前頭前野グルタミン酸作動性ニューロンの役割. 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2018. 28回・48回. 216-216
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三枝 理博, 櫻井 武. TOPICS(第4回)オレキシンと食行動・エネルギー代謝. ねむりとマネージメント = Sleep and management. 2016. 3. 1. 42-44
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Patents (2)：
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情報処理装置、睡眠覚醒ステージ判定装置、コンピュータプログラム、情報処理方法及び睡眠覚醒ステージ判定方法
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冬眠様状態を誘発する方法およびそのための装置
Books (68)：
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一般財団法人 放送大学教育振興会 放送大学教材 三訂版
2021 ISBN:9784595322624
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OREXIN SYSTEM: Basic Science and Role in Sleep Pathology
KARGER 2021 ISBN:9783318068443
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生体の科学
2020
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睡眠医療
エス・アールアカデミージャパン 2018 ISBN:9784898016381
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「こころ」はいかにして生まれるのか 最新脳科学で解き明かす「情動」
講談社 2018 ISBN:9784065135228
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Lectures and oral presentations (57)：
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Development of a Machine Learning Model to Evaluate Changes during Radiotherapy in Cervical Cancer Tumor Cells
(65th ANNUAL MEETING OF THE AMERICAN-SOCIETY-FOR-RADIATION-ONCOLOGY (ASTRO))
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オレキシン1受容体を介する疼痛制御メカニズムの解析
(日本薬学会第143年会)
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疲労困憊運動時に活動が高まる神経群の同定と操作
(Neuro2022)
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中脳水道周囲灰白質腹外側部GABA作動性ニューロンのカタプレキシー表出における役割
(Neuro2022)
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Induction of hypometablic and hypothermic states in mice.
(JST-CREST “Opt Bio”/WPI-IIIS Joint Symposium 2022)
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Education (2)：
- - 1993 University of Tsukuba Graduate School, Division of Medicine
- - 1989 University of Tsukuba Faculty of Medicine
Work history (3)：
- 1999/12 - 2004/03 University of Tsukuba Institute of Basic Medical Sciences
- 1993/08 - 1999/11 University of Tsukuba Institute of Basic Medical Sciences
- 1993/04 - 1993/08 日本学術振興会 特別研究員(PD枠)
Committee career (4)：
- 2013/10 - 現在 日本睡眠学会 評議員
- 1998 - 現在 日本心脈管作動物質学会 評議員
- 2016/11 - 2019/11 Society of Neuroscience Reviewing editior, J. Neurosci
- 2013/07 - 2015/06 日本睡眠学会 理事
Awards (3)：
- 2017/07 - 細胞科学財団 第2回 塩野賞 オレキシンのトランスレーショナルリサーチ
- 2001 - つくば奨励賞
- 1998 - 第4回国際神経内分泌学会優秀論文賞
Association Membership(s) (2)：
The Japanese Pharmacological Society
, Japanese Society for Circulation Research
