Rchr
J-GLOBAL ID：200901069461480290
Update date: Sep. 11, 2024
HAYASHI Mutsumi
ハヤシ ムツミ | HAYASHI Mutsumi
Affiliation and department：
Job title：
Assistant Professor
Research field (3)：
Fetal medicine/Pediatrics
, Tumor diagnostics and therapeutics
, Experimental pathology
Research theme for competitive and other funds (8)：
- 2022 - 2024 Development of transportable scFV monoclonal antibody into nucleus
- 2019 - 2022 Novel anti-cancer therapy against super-enhancer using humanized monoclonal antibody with transportation activity into nucleus
- 2019 - 2021 Development of ChIPseq method using pathological specimens and identification of disease-specific super-enhancer
- 2016 - 2019 Novel therapy against human cancers using intra-nuclear transportable humanized monoclonal antibody against CD26.
- 2013 - 2014 Development of molecular targeting therapy using nuclear-transpoted humanized monoclonal antibody
- 2011 - 2014 Human natural helper cells and its involvement in diseases
- 2010 - 2011 Partial tandem duplication in childhood acute myeloblastic leukemia and molecular targeted therapy
- 2004 - 2006 小児急性骨髄性白血病の動物モデルを用いたDIC発症の分子機構の解析
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Papers (9)：
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Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, Yanagawa H, Yamada T. Novel antibody-drug conjugate with anti-CD26 humanized monoclonal antibody and transcription factor IIH (TFIIH) inhibitor, triptolide, inhibits tumor rrowth via impairing mRNA synthesis. Cancers. 2019. 11. 8. 1138-1138
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Nishida H, Hayashi M, Morimoto C, Sakamoto M, Yamada T. CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma. Blood Cancer Journal. 2018. 8. 99
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Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, Yamada T. A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition. Cancer Cell International. 2016. 16. 35
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Nishida H, Suzuki H, Madokoro H, Hayashi M, Morimoto C, Sakamoto M, Yamada T. Blockade of CD26 Signaling Inhibits Human Osteoclast Development. J Bone Mineral Research. 2014. 29. 11. 2439-2455
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Yamada K, Hayashi M, Madokoro H, Nishida H, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T. Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription. PLoS One. 2013. 8. 4. e62304
ｍore...
MISC (2)：
Lectures and oral presentations (2)：
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Translational research of intranuclear transportable anti-CD26 antibody-drug conjugate
(2024)
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Nuclear translocation of multi-functional surface glycoprotein CD26 in cancer cells and CD26-targetted antibody therapy
(2023)
Education (2)：
- 1992 - 1998 Keio University Faculty of Medicine Depertment of Medicine
- - 1998 Keio University Faculty of Medicine
Professional career (1)：
Work history (3)：
- 2000 - 2004 大学医学部助手(専修医)(小児科学)
- 2002 - - 大学助手(医学部小児科学)
- 1998 - 2000 大学医学部研修医(小児科)
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