Rchr
J-GLOBAL ID：200901070321634458
Update date: Jan. 30, 2024
Ishii Seiji
イシイ セイジ | Ishii Seiji
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Affiliation and department：
Osaka Medical and Pharmaceutical University
About Osaka Medical and Pharmaceutical University
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Job title：
Assistant Professor
Research field (1)：
Medical biochemistry
Research keywords (8)：
ABC トランスポーター
, システインプロテアーゼ
, 連鎖球菌
, Quorum Sensing
, バイオフィルム
, Cysteine Protease
, Quorum Sensing
, Biofilm
Research theme for competitive and other funds (8)：
2022 - 2025 ストレプトコッカスのバイオフィルム感染症治療に向けた研究
2019 - 2022 Development of anti-biofilm drugs for streptococcal infection
2007 - 2008 Substrate Recognition Mechanism of the Peptidase Domain of ComA from Streptococcus Associated with Biofilm Infection
2004 - バイオフィルム、Quorum Sensingの生化学
2001 - 2003 Designing composite biocatalysts by analysis of the proton-transfer process in pyridoxal enzymes
1996 - 1996 芳香族L-アミノ酸デカルボキシラーゼの構造と機能相関の解明
Biochemical Study of Quorum Sensing
Biochemical Study of Biofilm
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Papers (17)：
石井 誠志, 福井 健二, 横島 聡, 熊谷 和夫, 紅山 容子, 兒玉 哲也, 福山 透, 岡部 隆義, 長野 哲雄, 小島 宏建, et al. Streptococcus属細菌のクオラムセンシング伝達経路を阻害する低分子化合物の探索. 生命科学系学会合同年次大会. 2017. 2017年度. [4AT26-1420)]
Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, et al. High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway. SCIENTIFIC REPORTS. 2017. 7. 1. 4029
Seiji Ishii, Takato Yano, Akihiro Okamoto, Takeshi Murakawa, Hideyuki Hayashi. Boundary of the nucleotide-binding domain of Streptococcus ComA based on functional and structural analysis. Biochemistry. 2013. 52. 15. 2545-55
Seiji Ishii, Takato Yano, Akio Ebihara, Akihiro Okamoto, Miho Manzoku, Hideyuki Hayashi. Crystal Structure of the Peptidase Domain of Streptococcus ComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285. 14. 10777-10785
Masashi Fukasawa, Qing Ge, R. Max Wynn, Seiji Ishii, Kosaku Uyeda. Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010. 391. 2. 1166-1169
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MISC (12)：
Seiji Ishii, Takato Yano, Akio Ebihara, Akihiro Okamoto, Miho Manzoku, Hideyuki Hayashi. Crystal Structure of the Peptidase Domain of Streptococcus ComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285. 14. 10777-10785
Yatsugu Kotake, Seiji Ishii, Takato Yano, Yoji Katsuoka, Hideyuki Hayashi. Substrate recognition mechanism of the peptidase domain of the quorum-sensing-signal-producing ABC transporter ComA from Streptococcus. BIOCHEMISTRY. 2008. 47. 8. 2531-2538
S Ishii, T Yano, H Hayashi. Expression and characterization of the peptidase domain of Streptococcus pneumoniae ComA, a bifunctional ATP-binding cassette transporter involved in quorum sensing pathway. JOURNAL OF BIOLOGICAL CHEMISTRY. 2006. 281. 8. 4726-4731
S Ishii, K Iizuka, BC Miller, K Uyeda. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004. 101. 44. 15597-15602
H Hayashi, F Tsukiyama, S Ishii, H Mizuguchi, H Kagamiyama. Acid-base chemistry of the reaction of aromatic L-amino acid decarboxylase and dopa analyzed by transient and steady-state kinetics: Preferential binding of the substrate with its amino group unprotonated. BIOCHEMISTRY. 1999. 38. 47. 15615-15622
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Books (2)：
Steroid 11β-hydroxylase/aldosterone synthase and its role in blood pressure regulation
Journal of Endocrinology 1997
新生化学実験講座 第9巻 ホルモンII非ペプチドホルモン
東京化学同人 1992
Lectures and oral presentations (29)：
Crystal Structure of the Nucleotide-Binding Domain of S. mutans ComA Involved in Quorum-sensing
(2012)
Streptococcus属細菌のComAペプチダーゼドメインの簡易活性測定を目的とした人工基質の検討
(第26回 Bacterial Adherence & Biofilm 2012)
Expression and Characterization of the Nucleotide-Binding Domain of Streptococcus ComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway
(IUMS2011 2011)
ストレプトコッカスの細胞外シグナル産生トランスポーターのペプチダーゼドメインの立体構造
(第83回日本細菌学会総会 2010)
Streptococcus属細菌のバイオフィルム感染症に関わるフェロモン産生プロテアーゼの立体構造によるユニークな基質認識機構の解明
(第82回日本生化学会大会 2009)
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Education (4)：
- 1992 Osaka University
- 1992 Osaka University Graduate School, Division of Medicine
- 1990 Tokyo University of Science Faculty of Science and Technology Applied Biological Science
- 1990 Tokyo University of Science Faculty of Science and Engineering
Professional career (2)：
M.S. (Osaka University)
Ph.D. (Osaka University)
Work history (4)：
1992 - 2007 Osaka Medical College
1992 - 2007 Research Associate, Osaka Medical College
2007 - Osaka Medical College
2007 - - Assistant Professor, Osaka Medical College
Association Membership(s) (4)：
日本細菌学会
, 日本生化学会
, Japanese Society for bacteriology
, The Japanese Biochemical Society
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