Takeda Kazuyoshi

Affiliation and department：
Job title： Associate Professor

Research field (3)： Tumor diagnostics and therapeutics , Oral medicine (pathology) , Immunology

Research theme for competitive and other funds (30)：

2023 - 2026 肝レジデント・メモリーT細胞の遺伝子・機能解析に基づいた肝移植後の新規免疫戦略
2021 - 2025 Analysis of immune suppressive mechanisms due to cancer mutation
2018 - 2021 抗腫瘍免疫に応答し癌細胞が免疫耐性変異する分子機構の解析
2018 - 2020 抗腫瘍免疫による癌増殖制御における癌微小環境の変化の解析
2015 - 2018 Innate immune regulation in metabolic steatohepatitis and experimental therapeutics

2015 - 2017 癌細胞に浸潤するB細胞の網羅的遺伝子解析に基づく抗腫瘍抗体の開発研究

2013 - 2016 Investigation of cancer therapeutic method without side effects: Suppression mechanisms of cancer metastasis on the lung by CXCL14/BRAK

2012 - 2014 From cancer therapeutics to cancer prevention: Investigation of suppression mechanisms of tumor growth and metastasis in cancer resistant mouse

2011 - 2014 特異的免疫反応から始まる癌を拒絶する生体反応の解析

2011 - 2013 がん微小環境により癌が免疫耐性を新規に獲得する機構の解析

2009 - 2011 Role of innate immune system in the regulation of hepatic metabolism and pathogenesis of steatohepatitis

2008 - 2010 Development of novel cancer therapy by combination of immune activation with tumor apoptosis induction

2008 - 2009 免疫による癌拒絶局所での分子機構の解析

2007 - 2008 Contribution of intracellular TRAIL receptor to regulation of apoptosis induced by TRAIL

2006 - 2007 Functional analysis of costimulatory molecules for autoimmune diseases

2004 - 2005 Investigation into regulation of immune responses by NK cells and NKT cells

2004 - 2005 REGULATION OF TUMOR VESSEL FORMATION BY THE IMMUNE SYSTEM

2004 - 2005 NK細胞、NKT細胞の機能調節による感染防御機構の制御

2004 - 2004 NK細胞、NKT細胞の機能分子による抗腫瘍免疫制御の解析

2003 - 2003 NK細胞、NKT細胞の機能調節による感染防御機構の制御

2002 - 2002 NK,NKT細胞による腫瘍拒絶および発癌監視機構の解析

2002 - 2002 NKT細胞による免疫系制御システムの解析

2001 - 2001 NK,NKT細胞による腫瘍拒絶機構の解析

1996 - 1996 胸腺外分化T(NK1.1^+T)細胞による自己免疫疾患の制御

1996 - 1996 ネズミマラリア感染防御における胸腺外分化T(NK1.1^+T)細胞の関与

NK細胞の機能

NK1⁺T細胞の機能

Analysis of anti-tumor immunity

functin of NK cells

function of NK1⁺T cells

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Papers (170)：

Ryu Matsumoto, Yin Enzhi, Kazuyoshi Takeda, Kodai Morimoto, Kyoko Yogo, Masaki Harada, Koji Tokushige, Yui Maehara, Saori Hirota, Yuko Kojima, et al. CD8+ T cell-mediated rejection of allogenic human-induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2024. 43. 8. 1348-1357
Satoshi Hanzawa, Makiko Sugiura, Susumu Nakae, Masahiro Masuo, Hideaki Morita, Kenji Matsumoto, Kazuyoshi Takeda, Ko Okumura, Masataka Nakamura, Tatsukuni Ohno, et al. The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice. International archives of allergy and immunology. 2024. 1-9
Masaki Shigematsu, Kazuyoshi Takeda, Satoru Matsunaga, Yuka Sendai, Nobutaka Matsuura, Reiya Suzuki, Toshifumi Azuma, Hodaka Sasaki, Ko Okumura, Hideshi Sekine, et al. Subgingival titanium wire implantation induces weak inflammatory responses but does not promote substantial T cell activation. Dental materials journal. 2023
長岡孝治, 小林由香利, 加藤洋人, 斎藤知子, 戸塚義和, 竹田和由, 石川俊平, 垣見和宏. scRNA-Seq、scTCR-Seqデータを用いたネオアンチゲン特異的TCRの同定と、それらを持つ2種類の疲弊T細胞の解析. 日本がん免疫学会総会プログラム・抄録集. 2023. 27回. 166-166
Pengwen Chen, Wenqian Yang, Koji Nagaoka, George Lo Huang, Takuya Miyazaki, Taehun Hong, Shangwei Li, Kazunori Igarashi, Kazuyoshi Takeda, Kazuhiro Kakimi, et al. An IL-12-Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023. e2205139

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MISC (186)：

小島裕子, 仁科隆史, 中野裕康, 奥村康, 竹田和由. インポーチンβ1阻害はTRAIL耐性腫瘍に対して抗Death Receptor5アゴニスティック抗体の抗腫瘍効果を増強する(Importin β1 inhibition augments anticancer effect of anti-DR5 agonistic antibody in TRAIL resistant tumor cells). 日本癌学会総会記事. 2019. 78回. P-3277
内田浩一郎, 場集田寿, 竹田和由, 垣生園子, 奥村康. 患者まで届いている再生医療誘導型抑制性T細胞による移植免疫寛容の誘導. 再生医療. 2019. 18. 3. 302-308
Akira Orimo, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliavi Sulidan, Yataro Daigo, Nadila Wali, Okio Hino, Kazuyoshi Takeda, Michiaki Hamada, Yuko Matsumura. CAFs induce formation of metastatic human breast tumor cell clusters with partial epithelial-mesenchymal transition. CANCER SCIENCE. 2018. 109. 797-797
内田浩一郎, 竹田和由, 藤本啓一, 場集田寿, 北浦次郎, 垣生園コ, 奥村康. 骨髄由来免疫抑制細胞MDSC移入によりアロ心移植においてグラフトは長期生着する. 日本外科学会定期学術集会(Web). 2018. 118th. ROMBUNNO.SF-058-5 (WEB ONLY)
Tomohisa Baba, Kazuyoshi Takeda, Soichiro Sasaki, Yasunari Nakarnoto, Naofumi Mukaida, Tatsushi Naito. Involvement of a chemokine, CCL3, in chemotherapeutic-induced tumor eradication by rapid recruitment of CD4-positive cytotoxic T cells into tumor sites. CYTOKINE. 2017. 100. 58-58

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Education (1)：

- 1987 Tohoku University Faculty of Dentistry

Committee career (4)：

2011 - 現在日本癌学会評議委員
2003 - 現在マクロファージ分子細胞生物学研究会運営委員
2003 - 現在日本がん転移学会評議員
2003 - 現在日本免疫学会評議員

Awards (1)：

2000 - 日本癌学会奨励賞

Association Membership(s) (9)：

日本サイトカイン学会 , 日本がん転移学会 , 日本癌学会 , 日本免疫学会 , The Society for Natural Immunity , 日本バイオセラピィ学会 , The Japanese Society of Gastroenterology , 日本がん免疫学会 , 日本食品免疫学会

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