Rchr
J-GLOBAL ID：200901070385019765
Update date: Feb. 01, 2024
Shimizu Takahiro
シミズ タカヒロ | Shimizu Takahiro
Affiliation and department：
Job title：
Associate Professor
Research field (2)：
Clinical pharmacy
, Physiology
Research keywords (2)：
細胞生理
, Cell physiology
Research theme for competitive and other funds (17)：
- 2022 - 2025 細胞の生死を制御するミトコンドリアと原形質膜のクロストーク機構の解明
- 2020 - 2025 Channel regulating mechanisms of lipid bilayers via chemical-physical transduction
- 2016 - 2019 PKD2L1カチオンチャネルによる苦味受容機構の解明
- 2018 - 2019 舌細胞の新規苦味受容機構の解明
- 2015 - 2018 Structural analysis of membrane protein based on multi-labeled sites
- 2015 - 2017 Elucidation of the molecular components and regulatory mechanism of anion channels controlling the cell homeostasis and death
- 2013 - 2016 Functional coupling between ion channels and scramblases in human TMEM16F-expressing cells
- 2012 - 2014 Elucidation of the unidentified molecular structure of the cell volume-sensitive anion channel
- 2009 - 2013 Molecular characterization of volume-activated anion channels and elucidation of cell death-survival switching mechanisms
- 2010 - 2013 Electrophysiological analysis of colonic ion secretion mechanism by TRP channels
- 2011 - 2012 抗癌剤耐性を制御するイオンチャネルの網羅的探索
- 2009 - 2011 Clarification of properties of chloride channels, SLC26A7 and 26A9, involved in novel cytoprotective mechanism
- 2009 - 2010 細胞容積調節機構におけるTMEM16チャネルファミリーの新規機能の解明
- 2005 - 2008 Channel-mediated mechanisms of induction of and protection against cell death
- 2005 - 2006 細胞容積調節機構に関わる非選択性カチオンチャネルの分子同定と細胞死への役割
- 2003 - 2004 アポトーシス性細胞容積減少メカニズムの解明
- 2002 - 2003 虚血性細胞容積膨張と虚血性細胞死誘導メカニズムの解明
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Papers (67)：
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Takuto Fujii, Mizuki Katoh, Manami Ootsubo, Oanh T T Nguyen, Mayumi Iguchi, Takahiro Shimizu, Yoshiaki Tabuchi, Yasuharu Shimizu, Hiroshi Takeshima, Hideki Sakai. Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+ ,K+ -ATPase α3-isoform in human cancer cells. Journal of cellular physiology. 2022. 237. 7. 2980-2991
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Takahiro Shimizu, Nobuhiro Yanase, Takuto Fujii, Haruka Sakakibara, Hideki Sakai. Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin. Biochimica et biophysica acta. Biomembranes. 2021. 1864. 1. 183782-183782
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Takuto Fujii, Kenji Sugimoto, Takafumi Noda, Takahiro Shimizu, Yuji Matsuya, Hideki Sakai. Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008. Biochemical and biophysical research communications. 2021. 567. 177-182
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Takuto Fujii, Takahiro Shimizu, Mizuki Katoh, Shushi Nagamori, Keiichi Koizumi, Junya Fukuoka, Yoshiaki Tabuchi, Akira Sawaguchi, Tomoyuki Okumura, Kazuto Shibuya, et al. Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase. iScience. 2021. 24. 5. 102412-102412
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Takahiro Shimizu, Takuto Fujii, Hironao Ohtake, Toshie Tomii, Ryuta Takahashi, Kentaro Kawashima, Hideki Sakai. Impaired actin filaments decrease cisplatin sensitivity via dysfunction of volume-sensitive Cl- channels in human epidermoid carcinoma cells. Journal of cellular physiology. 2020. 235. 12. 9589-9600
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MISC (33)：
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H. Mihara, H. Kishi, Y. Adachi, T. Shimizu, H. Sakai, M. Oku, A. Fujii. How Online Classes were Introduced to the Medical School Campus of a Regional University. Igaku Kyoiku. 2020. 51. 3. 255-257
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Y. Okada, K. Sato-Numata, T. Shimizu, H. Sakai, T. Akita, T. Okada. Anion Channels Involved in Cell Survival-Death Switching. JOURNAL OF GENERAL PHYSIOLOGY. 2013. 142. 2. 12A-13A
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Taiga Higuchi, Takahiro Shimizu, Takuto Fujii, Noriaki Takeguchi, Bernd Nilius, Hideki Sakai. Modulation of TRPP3 channel function by increasing temperature. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S196-S196
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Takahiro Shimizu, Yuta Takahashi, Takuto Fujii, Noriaki Takeguchi, Hideki Sakai. The role of Kv7.1 K+ channels in thromboxane A(2)-induced cell proliferation of human colonic cancer cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S198-S198
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Takuto Fujii, Yuji Takahashi, Kyosuke Fujita, Takahiro Shimizu, Noriaki Takeguchi, Hideki Sakai. Chloride-proton antiporter ClC-5 is functionally associated with gastric proton pump. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S218-S218
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Books (3)：
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Control and Diseases of Sodium Dependent Transportation Proteins and Ion Channels. Cell volume-sensitive Cl channel and ATP release
Elsevier, Amsterdam 2000
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Control and Diseases of Sodium Dependent Transportation Proteins and Ion Channels. Effect of extracellular Ca on volume sensitivity of the swelling-activated Cl channel in human epithelial cells
Elsevier, Amsterdam 2000
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Cell Volume Regulation: The Molecular Mechanism and Volume Sensing Machinery. ATP release from swollen or CFTR-expressing epithelial cells
Elsevier, Amsterdam 1998
Education (3)：
- 1997 - 2000 The Graduate University for Advanced Studies
- 1995 - 1997 Toyama Medical and Pharmaceutical University
- 1991 - 1995 Toyama Medical and Pharmaceutical University
Professional career (1)：
- Doctor of Science (The Graduate University for Advanced Studies)
Work history (7)：
- 2009/04 - University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
- 2008/07 - 2009/03 National Institute for Physiological Sciences
- 2006/10 - 2008/06 ベルギー・ルーベンカトリック大学・研究員
- 2002/07 - 2006/09 National Institute for Physiological Sciences
- 2002/04 - 2002/06 日本学術振興会特別研究員(生理学研究所)
- 2000/07 - 2002/03 National Institute for Physiological Sciences
- 2000/04 - 2000/06 科学技術振興事業団CREST研究員 (生理学研究所)
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Committee career (1)：
Association Membership(s) (2)：
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