Rchr

J-GLOBAL ID：200901070444723315 Update date: Aug. 21, 2024

Ueno Naoto

Affiliation and department：
Job title： Special Appointed Professor
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/40221105

Research field (1)： Developmental biology

Research keywords (18)： TGF-βファミリ- , スレオニンキナーゼ , 形態形成 , 骨形成 , 細胞分化 , パタ-ン形成 , シグナル伝達 , マイクロアレイ , 神経誘導 , 骨形成因子 , BMP , アクチビン , フォリスタチン , 胚誘導 , 細胞間相互作用 , 器官形成 , アフリカツメガエル , 初期発生

Research theme for competitive and other funds (43)：

2022 - 2028 生命科学連携推進協議会
2022 - 2028 Advanced Bioimaging Support
2021 - 2024 Force-dependent control of cell-to-cell adhesion;through the regulation of ZO;phase separation
2016 - 2021 先端バイオイメージング支援プラットフォーム
2016 - 2021 生命科学連携推進協議会

2015 - 2020 Virtual laboratory to accelerate international collaboration on 3D morphological logic

2015 - 2020 3D morphologic

2015 - 2020 Mechanical regulation of tissue folding and tube formation -The neural tube as a model-

2016 - 2019 Analysis of Force Field Generated by Active Deformation of Mesoderms during Morphogenesis

2015 - 2019 Molecular basis of periodic cellular dynamics to facilitate convergence movements

2015 - 2018 Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules

2015 - 2018 Cellular dynamics during collective cell migration

2013 - 2018 Investigating the mechanisms for GSC regulation in mouse gametogenesis

2013 - 2016 Development of methodologies to study Aiptasia-Symbiodinium symbiosis

2010 - 2016 Management of the research group on logic for biological pattern formation

2012 - 2015 Identification of the biological significance of small chemicals for morphogenesis

2010 - 2015 The logic of organogenesis based on cellular morphogenesis and cell motility

2009 - 2012 In vivo imaging of embryonic cell death in the new model animal and its molecular analysis

2009 - 2011 Significance of membrane/protein trafficking for the establishment of cell polarity in the vertebrate

2010 - 2010 マウス初期胚における細胞極性形成機構の細胞生物学的解析

2004 - 2008 Dynamics of Developmental Systems

2006 - 2007 Regulatory mechanisms of competence to respond to BMP signaling

2005 - 2007 Clarification of cell polarity formation mechanism in archenteron formation

2005 - 2006 Study for the cell lineage and tissue specificity in embryonic cells using transgenic Xenopus frogs

2003 - 2006 Development of mutant mice carrying base-substitutions in target genes.

2001 - 2005 Dynamics of signal transduction in the system of organogenesis and regeneration

2002 - 2004 Study of the mechanism of developmental toxicology by dioxin with cDNA microarray analysis

2001 - 2001 Molecular bases of the body-plan in vertebrate

2000 - 2000 アフリカツメガエルをモデルとした系統的遺伝子機能解析系の確

1997 - 2000 脊椎動物のボディープランの分子的基盤(計画班)

1996 - 1998 Neurogenesis and organogenesis of zebrafish and medaka

1996 - 1997 MOLECULAR MECHANISM OF EARLY DEVELOPMENTAL PATTERNING BY TGF-B FACTORS

1996 - 1997 MOLECULAR MECHANISM FOR NEURAL FROMATION BY BMP

1996 - 1996 脊椎動物のボディープランの分子的基盤

1995 - 1996 The establishment of screening system to identify compoundsthat target BMP receptor-associated molecules

1993 - 1996 形態形成の調節機構-初期発生を制御する分子機構

1995 - 1995 骨・歯牙再建誘導制御の分子生物学的研究に関するネットワークの調査

1995 - 1995 TGF-βスーパーファミリーによる組織形成機構をめぐる研究動向の調査

1994 - 1995 Structure and Functional Analysis of Bone Morphogenetic Protein Receptor

1994 - 1994 BMPによる細胞分化の調節機構

1993 - 1993 カエルの体軸形成におけるレセプター遺伝子の機能解析

1991 - 1992 Studies on the role of growth factors in embryonic inductions

1990 - 1992 Expression of BMP family proteins in mammalian cells and production of monoclonal antibodies

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Papers (254)：

Sayuki Hirano, Yohei Kondo, Noriyuki Kinoshita, Tetsuhisa Otani, Mikio Furuse, Naoto Ueno, Kazuhiro Aoki. ZO-1 shuttles between tight junctions and podosomes by riding ERK activation waves during collective cell migration. 2024
Makoto Suzuki, Naoko Yasue, Naoto Ueno. Differential cellular stiffness across tissues that contribute to Xenopus neural tube closure. Development, growth & differentiation. 2024
Yuki Shibata, Miyuki Suzuki, Nao Hirose, Ayuko Takayama, Chiaki Sanbo, Takeshi Inoue, Yoshihiko Umesono, Kiyokazu Agata, Naoto Ueno, Ken-ichi T. Suzuki, et al. CRISPR/Cas9-based simple transgenesis in Xenopus laevis. Developmental Biology. 2022
Noriyuki Kinoshita, Takamasa S. Yamamoto, Naoko Yasue, Chiyo Takagi, Toshihiko Fujimori, Naoto Ueno. Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions. iScience. 2022. 25. 2. 103846-103846
Hiroshi Koyama, Makoto Suzuki, Naoko Yasue, Hiroshi Sasaki, Naoto Ueno, Toshihiko Fujimori. Differential cellular stiffness contributes to tissue elongation on an expanding surface. 2022

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MISC (73)：

細胞は力刺激を受けると細胞間の接着を強くする? - 力のシグナル伝達による発生制御. 2020
上野直人. 細胞極性が生物を形作る. 医学のあゆみ. 2019. 268. 6. 469-473
Makoto Suzuki, Naoto Ueno. Periodic actomyosin contractility contributes to convergence movement during neurulation in zebrafish. MECHANISMS OF DEVELOPMENT. 2017. 145. S92-S92
Naoto Ueno, Takefumi Negishi. A novel membrane invagination controls oriented cell division in ascidian embryo. MECHANISMS OF DEVELOPMENT. 2017. 145. S4-S5
SAKAMAKI Kazuhiro, ISHII Takahiro M, SAKATA Toshiya, TAKEMOTO Kiwamu, TAKAGI Chiyo, TAKEUCHI Ayako, MORISHITA Ryo, TAKAHASHI Hirotaka, NOZAWA Akira, SHINODA Hajime, et al. Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage. Biochimica et Biophysica Acta. 2016. 1863. 11. 2766-2783

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Books (15)：

「対話」異形
慶應義塾大学出版会 2011 ISBN:9784766418941
ゲノム科学の基礎
岩波書店 2009 ISBN:9784000069618
ヒトの変異 : 人体の遺伝的多様性について
みすず書房 2006 ISBN:462207219X
発生システムのダイナミクス
共立出版 2006 ISBN:4320056345
キーワードで理解する発生・再生イラストマップ
羊土社 2005 ISBN:489706581X

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Lectures and oral presentations (19)：

Force-dependent remodeling of a tight junction protein ZO-1 is regulated by phase-separation
(18th International Xenopus Conference, Online 2021)
A snapshot from around Global BioImaging Part II - ABiS, Japan
(Global BioImaging Exchange of Experience IV, Singapore 2019)
Mechanical stress regulates epithelial tissue integrity during Xenopus gastrulation.
(The EMBO-EMBL Symposium: Mechanical Forces in Development, Heidelberg, Germany 2019)
Calcium dynamics and tissue mechanics of vertebrate neural tube closure. (Plenary lecture)
(InSDB2018, Indian Society of Developmental Biologists, Kanpur, India 2018)
Value of joining GBI - Japan's perspective as an established imaging infrastructure.
(Global BioImaging Exchange of Experience III, Sydney, Australia 2018)

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Work history (7)：

2022/04 - 現在 National Institutes of Natural Sciences, Headquarters for Co-Creation Strategy Department of Quantitative and Imaging Biology (QIB), Specially Appointed Professor
2022/04 - 現在 National Institutes of Natural Sciences, National Institute for Basic Biology, Trans-Scale Biology Center Optics and Imaging Facility Specially Appointed Professor
2004/04 - 2022/03 National Institutes of Natural Sciences, National Institute for Basic Biology Division of Morphogenesis Professor
1997/05 - 2004/03 岡崎国立研究機構基礎生物学研究所発生生物学研究系教授
1993/05 - 1997/05 Hokkaido University Faculty of Pharmaceutical Sciences

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Awards (1)：

1996 - 読売テクノフォーラム・ゴールドメダル賞「初期発生を制御する細胞増殖因子」

Association Membership(s) (3)：

International Society of Differentiation , International Society of Developmental Biologists , Japanese Society of Developmental Biologists

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