Rchr
J-GLOBAL ID:200901070618844737   Update date: Apr. 23, 2024

SUZUKI Takafumi

スズキ タカフミ | SUZUKI Takafumi
Affiliation and department:
Job title: Associate Professor
Other affiliations (1):
Homepage URL  (1): http://www.dmbc.med.tohoku.ac.jp/cgi-bin/profile7/ass8.cgi
Research field  (3): Medical biochemistry ,  Pathobiochemistry ,  Molecular biology
Research keywords  (5): ストレス応答 ,  Keap1-Nrf2 system ,  Cytoprotection ,  生化学 ,  分子生物学、生化学
Research theme for competitive and other funds  (37):
  • 2022 - 2025 Keap1-Nrf2制御系によるストレス応答の動的構造基盤の解明
  • 2021 - 2024 Development of Adverse Events-free Local Anesthetics in Cryo-EM Structural Determination of Sodium Channels
  • 2019 - 2024 Deciphering Molecular Basis for the Anti-Oxidative Stress Response and Application of the Basis for Disease Prevention and Therapy
  • 2019 - 2024 生体防御機能強化による宇宙ストレス克服法の開発
  • 2023 - 生体防御機構Keap1-Nrf2システムの活性制御メカニズムの解明
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Papers (72):
  • Jun Takahashi, Takafumi Suzuki, Miu Sato, Shuji Nitta, Nahoko Yaguchi, Tatsuki Muta, Kouhei Tsuchida, Hiromi Suda, Masanobu Morita, Shin Hamada, et al. Differential squamous cell fates elicited by NRF2 gain of function versus KEAP1 loss of function. Cell Reports. 2024
  • Kazuaki Ikejiri, Takafumi Suzuki, Satsuki Muto, Hirotaka Takama, Kengo Yamawaki, Tatsuya Miyazawa, Itaru Urakawa, Yuichi Aoki, Akihito Otsuki, Fumiki Katsuoka, et al. Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study. Clinical and Experimental Nephrology. 2024
  • Yu-Ichi Aoki, Keiko Taguchi, Hayato Anzawa, Junko Kawashima, Noriko Ishida, Akihito Otuki, Atsushi Hasegawa, Liam Baird, Takafumi Suzuki, Ikuko N Motoike, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. Journal of biochemistry. 2024
  • Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eiki Yoshida, Shimon Sakaguchi, Masayuki Yamamoto. Nrf2 activation improves experimental rheumatoid arthritis. Free Radical Biology and Medicine. 2023
  • Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023. 66. 102845-102845
more...
MISC (11):
  • 鈴木隆史. 宇宙環境マウス実験からヒト健康長寿研究へ. 細胞. 2023
  • 佐藤美羽, 矢口菜穂子, 鈴木隆史, 山本雅之. 含セレン抗酸化酵素合成破綻状態の恒常性維持におけるKeap1過酸化水素センサーの重要性の解明. 日本酸化ストレス学会学術集会プログラム・抄録集. 2023. 76th
  • 鈴木隆史. 環境ストレス応答の分子メカニズムと生理的意義の解明. 東北医学雑誌(Web). 2022. 134. 1
  • 鈴木隆史, 山本雅之. 宇宙マウス実験からヒト健康・長寿研究への還元を目指して. 医学のあゆみ. 2021. 279. 6. 632-639
  • T. Hidaka, E. Ogawa, E. Kobayashi, T. Suzuki, T. Fujimura, S. Aiba, R. Okuyama, M. Yamamoto. Aryl hydrocarbon receptor activation at keratinocyte leads to atopic dermatitis-like lesion via artemin induction. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015. 135. S2-S2
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Books (1):
  • 人体の細胞生物学 : カラー図解
    日本医事新報社 2018 ISBN:9784784932320
Lectures and oral presentations  (113):
  • Squamous cell carcinogenesis elicited by NRF2L30F plus Trp53R172H mutations.
    (The Environmental Response VI, Sendai, Japan)
  • Compensatory activation of Nrf2 in Selenoprotein Deficiency Requires Keap1 Cys226/Cys613 Residues.
    (The Environmental Response VI, Sendai, Japan)
  • NRF2 activation improves experimental rheumatoid arthritis.
    (The Environmental Response VI, Sendai, Japan)
  • NRF2 activation improves experimental rheumatoid arthritis.
    (The Environmental Response VI, Sendai, Japan)
  • Molecular basis of stress response by the KEAP-1NRF2 system.
    (The Environmental Response VI, Sendai, Japan)
more...
Education (3):
  • 2003 - 2007 筑波大学大学院博士課程人間総合科学研究科
  • 2001 - 2003 筑波大学大学院修士課程医科学研究科
  • 1997 - 2001 University of Tsukuba
Professional career (1):
  • 博士(医学) (筑波大学)
Work history (7):
  • 2022/04 - 現在 東北大学大学院医学系研究科/東北メディカル・メガバンク機構 分子医化学分野 准教授
  • 2016/04 - 2022/03 Tohoku University Graduate School of Medicine Faculty of Medicine
  • 2019/11 - 2020/02 University of Dundee Visiting Researcher
  • 2019/07 - 2019/07 Fred Hutchinson Cancer Center Visiting Researcher
  • 2008/04 - 2016/03 東北大学大学院医学系研究科 医化学分野 助教
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Awards (17):
  • 2023/11 - The Environmental Response VI Excellent poster award Squamous cell carcinogenesis elicited by NRF2L30F plus Trp53R172H mutations.
  • 2023/10 - 第96回日本生化学会大会 若手優秀賞 含セレン抗酸化酵素欠失状態の恒常性維持におけるKEAP1過酸化水素センサーの重要性
  • 2022/07 - Mishima Kaiun Memorial Foundation Mishima Kaiun Academic Award
  • 2022/01 - 東北大学医学部 奨学賞金賞
  • 2021/11 - 第94回日本生化学会大会 若手優秀賞 含セレン抗酸化酵素合成破綻状態の恒常性維持におけるKeap1過酸化水素センサーの重要性の解明
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Association Membership(s) (5):
日本酸化ストレス学会 ,  Association for Redox Research & Development Initiatives ,  THE JAPANESE CANCER ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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