Rchr

J-GLOBAL ID：200901071005961206 Update date: Dec. 23, 2024

TAGUCHI Toru

田口徹 | TAGUCHI Toru

Affiliation and department：
Homepage URL (1)： http://www.nuhw.ac.jp/

Research field (4)： Rehabilitation science , Neuropathology , Neuroscience - general , Sports science

Research keywords (16)： ion channel , mechanobiology , sensitization , spinal cord , fascia , c-Fos , single-fiber recording , shoulder stiffness , low back pain , tension-type headache , hyperalgesia , delayed onset muscle soreness , fibromyalgia , myofascial pain , nociceptor , pain

Research theme for competitive and other funds (38)：

2024 - 2028 筋/筋膜の温受容をトリガーとする中枢性鎮痛機構の解明
2024 - 2026 筋線維タイプ特異的活動操作を実現する基盤技術の構築と筋機能解明への応用
2022 - 2025 Establishment of morphological and histological basis of fascial structure and development of new exercise therapy
2022 - 2025 Central mechanisms of stress-induced pain and its physical therapy
2019 - 2024 Establishment of educational program and center for chronic musculoskeletal pain in physical therapy

2019 - 2024 知覚学習イノベーション-次世代感覚運動学習法の創出を目指してー

2019 - 2022 新規in vivoパッチクランプ法を用いた慢性筋痛の脊髄機構解明と治療薬の探索

2019 - 2022 遅発性筋痛の神経・分子機構解明とその理学療法効果の実証

2016 - 2022 Elucidation of membrane and sugar chain environment required for mechano-sensing/response and its application to the development of therapeutic strategy for muscle diseases

2017 - 2020 骨格筋損傷に有効な寒冷・温熱療法の刺激条件とは?

2016 - 2019 Mechanism and treatment of hyperalgesia originating in fascia

2017 - 2018 Mechanisms and treatment of chronic pathological pain using an animal model of fibromyalgia

2016 - 2018 Demonstration of effector function in nociceptors and pain regulation by their selective manipulation

2014 - 2017 Identifying new nociceptor in skeletal muscle and its involvement in hyperalgesia

2016 - 2017 Therapy for sarcopenia-related diseases by optogenetic manipulations of skeletal muscle in vivo

2014 - 2017 Analysis of muscular properties as a pain-sensitizing agent-producing tissue

2015 - 2016 Pain therapy by optogenetic manipulation of sensory afferents

2013 - 2016 Neural mechanisms and treatment of stress-induced myofascial pain

2013 - 2015 Novel sensitizing mechanism for nociceptors through extracellular matrix proteoglycans

2012 - 2015 Investigation of a role for multifunctional mechanosensor TRPV2 in adult sensory neuron and pain

2014 - 2015 Determining factors of delayed onset muscle soreness and its neural and molecular mechanisms

2014 - 2015 Lack of exercise-induced chronic pain and the novel therapy using optogenetics

2012 - 2015 Novel roles of fascia as a nociceptive sensor in basic medical sciences

2013 - 2014 Analysis of spontaneous electrical activity in myofascial tissue: Application for diagnosis and treatment in acupuncture medicine

2012 - 2014 Development of a medical device visualizing and hearing the diagnosis and treatment of muscle pain

2011 - 2014 Involvement of neurotrophic factors in muscular pain and their expression and action mechanisms

2012 - 2013 Role and activation mechanisms of silent nociceptors in hyperalgesia

2011 - 2013 Role of myofascial silent nociceptors and their activation mechanisms

2011 - 2012 Pathological mechanisms underlying fibromyalgia

2011 - 2012 Peripheral and central neural mechanisms of fibromyalgia

2010 - 2011 Muscular and fascial nociceptors: Do we know all types

2010 - 2011 Mechanisms involved in excitation and facilitation of peripheral nociceptors by acromelic acid

2010 - 2011 Role of silent nociceptors in the muscle and the fascia

2008 - 2011 Spinal and supraspinal mechanisms of muscular nociception in a rat model of delayed onset muscle soreness

2009 - 2011 Elucidation of the mechanisms of nociceptor excitation by noxious temperature

2008 - 2010 Role of nerve growth factor (NGF) in muscular pain

2008 - 2009 Mechanical sensitization of muscular polymodal receptors in a rat model of muscle pain

2008 - 2009 Action mechanisms of mushroom poison (acromelic acid) on peripheral nociceptors

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Papers (61)：

Daisuke Uta, Katsuyuki Tsuboshima, Kazue Mizumura, Hisao Nishijo, Toru Taguchi. Amitriptyline and duloxetine attenuate activities of superficial dorsal horn neurons in a rat reserpine-induced fibromyalgia model. Journal of Pharmacological Sciences. 2024. 156. 3. 180-187
Yoshikazu Taketa, Keigo Tamakoshi, Kazuki Hotta, Shutaro Maki, Toru Taguchi, Hideaki Takahashi. Lymphatic capillarization in different fiber types of rat skeletal muscles with growth and age. Microcirculation. 2024. e12879
Hiroki Ota, Rihito Oi, Kimiaki Katanosaka, Kazue Mizumura, Toru Taguchi. Expression profiles of Tmem120A/TACAN in rat skeletal muscle subjected to exercise and inflammation. PAIN RESEARCH. 2024. 39. 1. 35-39
Kazue Mizumura, Toru Taguchi. Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness. The Journal of Physiological Sciences. 2024. 74. 1. 4
Teruaki Nasu, Riku Kainuma, Hiroki Ota, Kazue Mizumura, Toru Taguchi. Increased nociceptive behaviors and spinal c-Fos expression in the formalin test in a rat repeated cold stress model. Neuroscience Research. 2024. 198. 30-38

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MISC (4)：

歌大介, 坪島功幸, 坪島功幸, 西条寿夫, 松田康佑, 澤幡雅仁, 久米利明, 水村和枝, 田口徹. Facilitated mechanical sensitivity of superficial spinal dorsal horn neurons in a rat model of fibromyalgia. 日本薬学会年会要旨集(Web). 2023. 143rd
太田大樹, 坪島功幸, 片野坂公明, 金川基, 田口徹. 運動の繰り返し効果における糖鎖ヒアルロン酸の役割. 日本筋学会学術集会プログラム・抄録集. 2022. 8回. 111-111
田口徹, 安井正佐也, 久保亜抄子, 阿部真博, 木山博資, 山中章弘, 水村和枝. 筋膜は侵害受容を担う感覚組織である. Journal of Musculoskeletal Pain Research. 2013. 5. 3. S34-S34
田口徹, 安井正佐也, 久保亜抄子, 阿部真博, 水村和枝, 木山博資, 山中章弘. 侵害受容組織としての筋膜の新しい生理的役割. 日本生理学雑誌. 2013. 75. 4. 197-197

Books (32)：

遅発性筋痛(いわゆる運動後の筋肉痛)はどこまでわかったか
2024
Expression profiles of TACAN in the muscle of a rat model of delayed onset muscle soreness
2022
社会的敗北ストレスモデルラットでは侵害刺激に対する脊髄後角表層ニューロンの興奮性が増大する
2022
遅発性筋痛の機構をめぐる最新知見. 特集:「疼痛基礎科学アップデート」
2022
Histological Changes in Skeletal Muscle of a Rat Reserpine-induced Fibromyalgia Model
Japanese Society of Physical Therapy 2022

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Lectures and oral presentations (274)：

運動の繰り返し効果における糖鎖ヒアルロン酸の役割
(日本筋学会学術集会プログラム・抄録集 2022)
線維筋痛症モデルラットの脊髄後角ニューロンの興奮性増大に対する抗うつ薬アミトリプチリンの抑制効果
(第24回日本基礎理学療法学会 2019)
ラットおよびマウス遅発性筋痛モデルの機械痛覚過敏におけるTRPA1の関与
(第24回日本基礎理学療法学会 2019)
線維筋痛症モデルマウスのうつ症状に対する運動療法の抑制効果
(第24回日本基礎理学療法学会 2019)
c-Fosタンパクの発現を指標にした線維筋痛症の脊髄機構解明
(第24回日本基礎理学療法学会 2019)

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Work history (4)：

2017/06 - 現在 Niigata University of Health and Welfare Department of Physical Therapy Professor
2016/03 - 2017/05 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences Visiting Associate Professor
2015/04 - 2016/02 Nagoya University Research Institute of Environmental Medicine
2007/09 - 2015/03 Nagoya University Research Institute of Environmental Medicine Assistant Professor

Committee career (3)：

2021/09 - 現在日本基礎理学療法学会評議員
2019/07 - 現在日本疼痛学会代議員
2011/03 - 現在日本生理学会評議員

Association Membership(s) (11)：

International Association for the Study of Pain , Japan Neuroscience Society , Japanese Association for the Study of Pain , Physiological Society of Japan , 新潟医療福祉学会 , JAPANESE ASSOCIATION OF PHYSICAL THERAPY FUNDAMENTALS , 骨格筋細胞研究会 , JAPANESE ASSOCIATION FOR THE STUDY OF MUSCULOSKELETAL PAIN , 日本線維筋痛症学会 , 日本筋学会 , JAPANESE PHYSICAL THERAPY ASSOCIATION

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