Rchr
J-GLOBAL ID:200901071192204626
Update date: Oct. 21, 2024
Suzuki Eriko
Suzuki Eriko
Affiliation and department:
Job title:
Professor
Other affiliations (3):
Research field (1):
Tumor biology
Research keywords (1):
微生物が生み出す、血栓溶解活性を有する化合物、慢性炎症やメタボリックシンドロームなどを改善する化合物などについて研究しています。私達の発見した化合物の中には、既に動物モデルで、脂肪肝や脳梗塞への優れた治療効果が見出されているものもあり、現在医薬開発を進めています。また、最近では、癌と低酸素培養真菌の共培養上清中に、癌幹細胞の形質を有し、より腫瘍形成能の高い癌幹細胞亜集団(holoclone)の増殖抑制活性を見出し、活性物質の同定と、作用機序解析も行っています。
Research theme for competitive and other funds (3):
- 2017 - 2017 新規創薬標的としてのEPHX2 phosphatase:生理的基質と阻害剤の探索
- 2014 - 2017 抗炎症化合物SMTP-7の脂肪肝改善作用におけるsEHとERストレスの寄与の検討
- 2010 - 2013 腎癌細胞における有機アニオントランスポーターOAT1の薬剤感受性への寄与
Papers (39):
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Kosuke Shimizu, Naoko Nishimura, Taolin Wang, Tetsuro Yamamoto, Eriko Suzuki, Keiji Hasumi. Anti-angiogenic activity of a novel angiostatin-like plasminogen fragment produced by a bacterial metalloproteinase. Heliyon. 2024. 10. 15. e35232
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Feng Liu, Xueying Diao, Haolun Cong, Eriko Suzuki, Keiji Hasumi, Hiroshi Takeshima. Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages. iScience. 2023. 26. 8. 107465-107465
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Yasuhiro Kihara, Erina Nishimura, Chisato Kanai, Yoshikazu Kitano, Eriko Suzuki, Keiji Hasumi. Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase. Bioscience, biotechnology, and biochemistry. 2023. 87. 5. 511-515
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Eriko Suzuki, Naoki Masaka, Tatsuhiro Urabe, Madoka Sasaki, Keiji Hasumi. Direct cell-cell interaction regulates division of stem cells from PC-3 human prostate cancer cell line. Biochemical and biophysical research communications. 2022. 631. 25-31
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Ryota Iwama, Yu Sasano, Taichi Hiramatsu, Shinya Otake, Eriko Suzuki, Keiji Hasumi. Amine-Regulated pri-SMTP Oxidation in SMTP Biosynthesis in Stachybotrys: Possible Implication in Nitrogen Acquisition. Journal of fungi (Basel, Switzerland). 2022. 8. 9
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MISC (34):
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高垣総一郎, 高垣総一郎, 鈴木麻衣子, 鈴木絵里子, 蓮見惠司. 脂肪酸によるsubtilisin NAT(ナットウキナーゼ)活性の促進. 日本血栓止血学会誌. 2019. 30. 2. 466
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鈴木絵里子, 田島真梨絵, 中野真衣, 廣嵜響, 木下春奈, 蓮見惠司. 生理活性物質SMTP-7によるβ2アドレナリン受容体-IL-6シグナル増強を介した血管炎症制御機構の解明. 日本血栓止血学会誌. 2019. 30. 2. 430
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鈴木絵里子, 廣崎響, 田島真梨絵, 悴田正浩, 阿部純己, 松本直欣, 蓮見惠司. 血管内皮炎症制御における可溶性エポキシドハイドロラーゼN末端phosphataseの機能の解析. 日本血栓止血学会誌. 2017. 28. 2. 238
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E. Suzuki, K. Umezawa, B. Bonavida. Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis (Retraction of vol 26, pg 6184, 2016). ONCOGENE. 2016. 35. 42. 5576-5576
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蓮見 惠司, 西村 直子, 長谷川 啓子, 鈴木 絵里子, 澤田 裕伸, 本田 一男, 冨永 悌二, 新妻 邦泰, 若林 祐里江, 森豊 隆志, et al. プラスミノゲン活性化を促進する新規脳梗塞治療薬の非臨床および臨床開発. 日本血栓止血学会誌. 2016. 27. 2. 263-263
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Patents (1):
Books (5):
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新規脳梗塞治療薬SMTP-7の抗炎症作用機序の解析
一般社団法人日本血栓止血学会 2015
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臨床遺伝学'09 -がんの遺伝子学-
最新医学社 2009
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がんの分子標的治療
南山堂 2008
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医学のあゆみ
医歯薬出版 2008
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バイオ医薬の開発技術とシーズ
シーエムシー出版 2008 ISBN:9784781300771
Lectures and oral presentations (53):
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The biological role of soluble epoxide hydrolase N-terminal phosphatase and a novel approach for the identification of its physiological substrate
(第90回日本生化学会 2017)
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Investigation of the responsible factors governing the cancer microbiome and crosstalk among cancer cells
(第90回日本生化学会 2017)
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Nterm-phosphatase of soluble epoxide hydrolase (sEH) in the regulation of inflammation
(International exchange meeting at Lingnan Normal University 2017)
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HABP2 (PHBP/FSAP) is the major plasma protease that promote extracellular histone degradation
(60th International Society of Thrombosis and Haemostasis 2017)
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Nterm-phosphatase of soluble epoxide hydrolase (sEH) in the regulation of vascular endothelial inflammation
(60th International Society of Thrombosis and Haemostasis 2017)
more...
Education (4):
- 2008 - 2010 Keio University Graduate School Graduate School of Medicine
- 2005 - 2008 Keio University Graduate School of Science and Technology Faculty of Science and Technology
- 2003 - 2005 Keio University Graduate School of Science and Technology Graduate School of Science and Technology Faculty of Science and Technology
- 1999 - 2003 Keio University Science and Technology Department of Applied Chemistry
Professional career (1):
Work history (6):
Awards (7):
- 2018/07 - International Society on Thrombosis and Hemostasis Early Career Award, 27th International Society on Thrombosis and Hemostasis
- 2016/10/21 - The 1st Joint Meeting of ISFP and PA Workshop Travel Grants for Young Investigators, The 1st Joint Meeting of ISFP and PA Workshop
- 2015/05/21 - 日本血栓止血学会学術奨励賞
- 2013/07 - International Society on Thrombosis and Haemostasis Young Investigator Awards, 24th International Society on Thrombosis and Haemostasis
- 2011/07 - International Society on Thrombosis and Haemostasis Young Investigator Awards, 23th International Society on Thrombosis and Haemostasis
- 2007/11 - 慶應義塾大学 国際学会論文発表奨励賞
- 2006/09 - 慶應義塾大学21世紀COEプログラム 21st COE program Best Poster Presentation Award
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Association Membership(s) (2):
Japan Society for Bioscience, Biotechnology and Agrochemistry
, Japanese society on Thrombosis and Haemostasis
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