Rchr
J-GLOBAL ID:200901071301101140
Update date: Apr. 23, 2024
Tsumaki Noriyuki
ツマキ ノリユキ | Tsumaki Noriyuki
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.cira.kyoto-u.ac.jp/j/research/tsumaki_summary.html
Research field (1):
Functional biochemistry
Research keywords (3):
軟骨代謝
, Regenerative medicine
, 整形外科
Research theme for competitive and other funds (22):
- 2023 - 2028 シングルセル網羅的発現解析とiPS細胞モデルによるヒト軟骨分化機構の解明
- 2018 - 2023 Analysis of regulatory mechanisms for differentiation of human cartilage tissue
- 2018 - 2021 Analysis of mechanism of bone fragility and effects of drugs in osteogenesis imperfecta using a graft model for enchondral bone formation
- 2016 - 2019 Comparative evaluation of human tissue-derived chondrocyte sheets and allogeneic chondrocyte sheets fabricated from a novel cell source, iPS cell-derived cartilaginous tissue
- 2015 - 2018 Analysis of regulation of chondrocyte differentiation by SIK3 and lipid metabolism
- 2013 - 2017 Analysis of mechanism for chondrocyte differentiation and maintenance that overcome cell aging
- 2014 - 2016 Screening of small compounds and factors to re-differentiate dedifferentiated chondrocytes in 2D culture
- 2013 - 2016 Establishment of the treatment and pathophysiology based on the suppression of the intervertebral disc degeneration .
- 2012 - 2015 Investigation of molecular and mechanosensitive mechanisms on lubricin-targeted gene expression specific to the surface of joint
- 2012 - 2015 Analysis of regulatory mechanisms controlling proliferation and differentiation of chondrocytes
- 2012 - 2014 Modeling type II collagenopathy
- 2009 - 2014 組織幹細胞/前駆細胞を誘導するディレクテッドリプログラミング技術の開発
- 2009 - 2012 Analysis of BMP-mediated cartilage formation anddifferentiation, and cartilage repair
- 2008 - 2010 Development of highly functional bone substitutes for bone regeneration
- 2006 - 2009 Analysis of cartilage formation and differentiation through regulation of chondrocyte signaling and transcription of matrix genes
- 2007 - 2008 脂肪細胞から核の初期化を経て誘導した軟骨細胞による軟骨修復
- 2005 - 2007 Development of new strategy focusing on transcription factor as the therapeutic target for intractable bone and joint disease
- 2005 - 2006 超音波刺激,人工骨,骨形成因子(BMP)シグナル操作を組み合わせた骨欠損の修復
- 2003 - 2006 軟骨分化制御メカニズムの解明
- 2003 - 2006 Development of Novel Hybrid Bone Substitute with Stem cells and Growth Factors
- 2003 - 2005 Analysis transcriptional regulation of cartilage genes
- 1999 - 1999 軟骨コラーゲン遺伝子の転写制御メカニズムの解析
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Papers (105):
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Shinichi Nakagawa, Wataru Ando, Kazunori Shimomura, David A. Hart, Hiroto Hanai, George Jacob, Ryota Chijimatsu, Seido Yarimitu, Hiromichi Fujie, Seiji Okada, et al. Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles. npj Regenerative Medicine. 2023. 8. 1
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Hiroki Hagizawa, Saeko Koyamatsu, Seiji Okada, Takashi Kaito, Noriyuki Tsumaki. Chondrocyte-like cells in nucleus pulposus and articular chondrocytes have similar transcriptomic profiles and are paracrine-regulated by hedgehog from notochordal cells and subchondral bone. Frontiers in Cell and Developmental Biology. 2023. 11
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Kengo Abe, Akihiro Yamashita, Miho Morioka, Nanao Horike, Yoshiaki Takei, Saeko Koyamatsu, Keisuke Okita, Shuichi Matsuda, Noriyuki Tsumaki. Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect. Nature Communications. 2023. 14. 1
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内山 綾香, 佐藤 正人, 高橋 匠, 豊田 恵利子, 前原 美樹, 大村 はるか, 小川 真梨奈, 森岡 美帆, 山下 晃弘, 渡辺 雅彦, et al. 低血清および低酸素条件下におけるiPS細胞由来軟骨細胞シートの硝子軟骨修復能の向上. 日本整形外科学会雑誌. 2022. 96. 8. S1556-S1556
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Michihiko Sugimoto, Yuhki Tada, Shigeyuki Shichino, Saeko Koyamatsu, Noriyuki Tsumaki, Kuniya Abe. Universal Surface Biotinylation: a simple, versatile and cost-effective sample multiplexing method for single-cell RNA-seq analysis. DNA Research. 2022. 29. 3
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MISC (126):
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武井義明, 武井義明, 小林与人, 堀家なな緒, 森岡美帆, 高才東, 釜谷崇志, 山下晃弘, 竹森洋, 妻木範行. Salt inducible kinase 3 (SIK3) mediate shear stress-induced up-regulation of lubricin at the articular cartilage surface. 日本軟骨代謝学会プログラム・抄録集. 2020. 33rd
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牧野紘士, 関庄二, 箭原康人, 塩沢俊一, 妻木範行, 木村友厚. 椎間板変性に対する選択的c-Fos/AP-1阻害薬の治療効果. 日本軟骨代謝学会プログラム・抄録集. 2018. 31st
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Tsumaki Noriyuki. Application of iPS cell technologies to regenerate articular cartilage damage and model skeletal dysplasia. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2018. WCP2018. SY42-3
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A Therapeutic Target of Intervertebral Disc Disease and Regeneration Based on Suppressing Intervertebral Disc Degeneration. Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research. 2017. 8. 6. 1127-1131
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妻木 範行. iPS細胞および分子標的によるOA治療戦略 (特集 OAの最新治療 : 関節再生を目指して). 分子リウマチ治療. 2017. 10. 2. 61-64
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Lectures and oral presentations (16):
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“Construction of biodigital twin for osteoarthritis”
(International PRIMe Symposium 2024)
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骨格発生と再生治療の研究開発
(第 27 回リウマチフォーラム 2024)
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再生医療の基礎開発、臨床応用そして企業とのコラボレーション
(第 5 回 再生医療等製品および周辺産業の規制動向討論会 2024)
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軟骨再生医療の最先端 軟骨発生研究とiPS細胞を使った軟骨再生治療法開発
(第1回日本膝関節学会 2023)
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同種iPS細胞由来軟骨移植による関節軟 骨損傷の再生治療法の開発
(第59回日本移植学会総会 2023)
more...
Works (4):
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厚生労働科学研究費補助金 免疫アレルギー疾患予防・治療研究事業
2006 -
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超音波刺激,人工骨,骨形成因子(BMP)シグナル操作を組み合わせた骨欠損の修復
2006 -
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軟骨細胞シグナリングとマトリックス転写制御による軟骨形成・分化の解明
2006 -
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難治性骨折治癒過程におけるBMPシグナル作用機構の解明
2005 -
Education (3):
- 1992 - 1996 大阪大学大学院 医学研究科博士課程
- - 1996 Osaka University Graduate School, Division of Medicine
- 1983 - 1989 Osaka University Faculty of Medicine Medical School
Professional career (1):
Work history (9):
- 2021/07 - 現在 Graduate School of Medicine, Osaka University Department of Biochemistry and Molecular Biology Professor
- 2011/06 - 現在 Kyoto University
- 2007/04 - 2011/05 Osaka University Graduate School of Medicine
- 2002/08 - 2007/03 大阪大学大学院 医学系研究科 整形外科 助手
- 1999/04 - 2002/07 大阪警察病院 整形外科 副医長
- 1998/01 - 1999/03 Osaka University Faculty of Medicine
- 1996/06 - 1998/01 米国国立保健研究所(NIH) Visiting fellow
- 1996/04 - 1996/05 Osaka University Faculty of Medicine
- 1989/05 - 1992/03 Osaka University Hospital
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Awards (6):
- 2008 - 日本骨代謝学会研究奨励賞
- 2000 - 日本骨代謝学会優秀演題賞
- 2000 - 日本整形外科学会奨励賞
- 1998 - 日本骨代謝学会優秀演題賞
- 1997 - 日本結合組織学会賞
- 1996 - 日本軟骨代謝学会賞
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Association Membership(s) (8):
The American Society for Bone and Mineral Research
, 米国骨代謝学会
, 日本結合組織学会
, 日本軟骨代謝学会
, 日本骨代謝学会
, 日本リウマチ学会
, 日本整形外科学会
, The American Society for Bone and Mineral Research
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