Shigeto Shimmura

シンムラシゲト | Shigeto Shimmura

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://lab.ophthal.med.keio.ac.jp/program/ccb

Research field (1)： Ophthalmology

Research theme for competitive and other funds (28)：

2022 - 2025 間葉系幹細胞(MSC)の生体内作用における新たな細胞極性化の証明
2021 - 2024 iPS細胞由来角膜内皮代替細胞移植のFirst-in-human臨床研究
2019 - 2022 Development of a novel drug to treat corneal dystrophy by drug repositioning
2019 - 2022 ドラッグ・リポジショニングによるフックス角膜変性症治療薬の開発
2016 - 2019 Effect of a Sema3A inhibitor treatment in a murine dry eye model

2016 - 2019 Elucidating the pathogenesis of Fuchs corneal dystrophy using disease iPSCs

2016 - 2019 フックス角膜内皮変性症の疾患特異的iPS細胞による病態解明

2016 - 2019 iPS細胞由来治療用角膜内皮代替細胞に関する臨床研究

2015 - 2018 Immunological properties of corneal endothelial cells derived from human induced pluripotent stem cells

2015 - 2017 Label retaining cells in long term cultured confluent epithelial cell sheets

2014 - 2017 A significant role of senescent cells and donor mesenchymal stem cells in ocular chronic graft-versus-host disease and development of new therapy

2013 - 2016 皮膚由来多能性前駆細胞から角膜内皮細胞への分化誘導

2013 - 2015 Melanocyte stem cells as a niche for corneal epithelial stem cells

2012 - 2015 Directed induction of skin derived precursors into corneal endothelium

2011 - 2013 Focus on mechanism of chronic ocular graft-vessus-host disease caused by donor-derived mesenchymal stem cells toward development of new treatment.

2009 - 2012 酸素濃度による角膜幹細胞の分化・増殖制御機構の解明

2010 - 2012 Analyssis of the fate determination mechanism to corneal epithelial cells using fluorescent reporter

2008 - 2011 再生医療実現化を目指したヒトiPS細胞・ES細胞・体性幹細胞研究拠点

2009 - 2011 Regulation mechanism of corneal stem cell differentiation and proliferation by oxygen concentration

2009 - 2010 A semaphorin 3A inhibitor accelerates cornel reinnervation following penetrating keratoplasty on mice

2008 - 2010 Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention

2007 - 2008 The mechanism of peripheral nerve regeneration following corneal transplantation on mice

2005 - 2007 低酸素培養による角膜幹細胞の分離

2005 - 2006 Hypoxic culture in the isolation of corneal stem cells

2001 - 2003 角膜上皮細胞におけるラクトフェリンレセプターと酸化ストレス

2001 - 2002 角膜上皮細胞におけるラクトフェリンレセプターと酸化ストレス

1996 - 1998 角膜上皮細胞におけるヘムオキシゲナーゼを介した酸化ストレス防御機構の解明

1996 - 1996 角膜上皮細胞におけるヘムオキシゲナーゼを介した酸化ストレス防御機構の解明

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Papers (282)：

Robert M Rusch, Emi Inagaki, Hiroko Taniguchi, Saki Sakakura, Rie Tamai, Hidenori Nonaka, Shota Shimizu, Shinri Sato, Yoko Ogawa, Hirayama Masatoshi, et al. Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation. The ocular surface. 2024. 34. 523-534
Shinri Sato, Yoko Ogawa, Eisuke Shimizu, Kazuki Asai, Takahiro Okazaki, Robert Rusch, Masatoshi Hirayama, Shigeto Shimmura, Kazuno Negishi, Kazuo Tsubota. Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model. The ocular surface. 2024. 32. 198-210
Shigeto Shimmura, Emi Inagaki, Masatoshi Hirayama, Shin Hatou. The Cornea: An Ideal Tissue for Regenerative Medicine. The Keio journal of medicine. 2024. 73. 1. 1-7
Anna Altshuler, Aya Amitai-Lange, Waseem Nasser, Shalini Dimri, Swarnabh Bhattacharya, Beatrice Tiosano, Ramez Barbara, Daniel Aberdam, Shigeto Shimmura, Ruby Shalom-Feuerstein. Eyes open on stem cells. Stem cell reports. 2023. 18. 12. 2313-2327
Saki Sakakura, Emi Inagaki, Tomoko Sayano, Risa Yamazaki, Noemi Fusaki, Shin Hatou, Masatoshi Hirayama, Kazuo Tsubota, Kazuno Negishi, Hideyuki Okano, et al. Non-apoptotic regulated cell death in Fuchs endothelial corneal dystrophy. Regenerative therapy. 2023. 24. 592-601

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MISC (133)：

三田村浩人, 榛村重人. 眼科医の手引表層・深層角膜移植. 日本の眼科. 2021. 92. 6. 683-684
西田幸二, 村上晶, 東範行, 島崎潤, 宮田和典, 山田昌和, 外園千恵, 白石敦, 榛村重人, 臼井智彦, et al. 前眼部形成異常の診療ガイドライン. 日本眼科学会雑誌. 2021. 125. 6. 605-629
關口真理奈[色川], 水野未稀, 内野裕一, 榛村重人, 坪田一男. 円錐角膜に対する全層角膜移植と深層層状角膜移植の術後経過の比較. あたらしい眼科. 2021. 38. 5. 584-587
榛村重人. 白内障と角膜移植の同時手術. 日本眼科学会雑誌. 2021. 125. 臨増. 151-151
榛村真智子, 榛村重人. 【眼表面上皮再建術アップデート】他家輪部移植. 眼科手術. 2021. 34. 1. 5-9

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Education (1)：

1989 - Keio University 医学部

Work history (2)：

2023/04 - 現在 Fujita Health University Clinical Regenerative Medicine Professor
2022/04 - 現在 Fujita Medical Innovation Center Tokyo Chairman

Awards (6)：

2022/07 - American Academy of Ophthalmology Senior Achievement Award
2016/01 - Association for Research in Vision and Ophthalmology Gold Fellow
2010/05 - American Academy of Ophthalmology Achievement Award
2004/02 - 日本角膜学会学術奨励賞
2003/07 - 東京歯科大学学長奨励研究賞

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