Rchr
J-GLOBAL ID：200901072164290912
Update date: Sep. 13, 2024
Kobayashi Masanobu
コバヤシ マサノブ | Kobayashi Masanobu
Affiliation and department：
Homepage URL (1)：
http://www.hoku-iryo-u.ac.jp/~mkobaya/Kobayashi/Welcome.html
Research field (3)：
Hematology and oncology
, Gastroenterology
, Experimental pathology
Research keywords (10)：
低酸素適応応答
, 遺伝子治療
, アポトーシス
, 抗癌剤耐性
, 癌化学療法
, Adaptation response to hypoxia
, Gene therapy
, Apoptosis
, Drug resistance
, Chemotherapy
Research theme for competitive and other funds (56)：
- 2012 - 2015 The roles of HDAC and transcription factors in oral cancer development
- 2012 - 2015 Regulation of adaptive responses to hypoxia and glucose deprivation by NAD-dependent deacetylase SIRT7
- 2009 - 2011 Establishment of optimal anti-angiogenic therapy against cancer of oral cavity
- 2008 - 2009 炎症発癌を標的とした阻害性低分子化合物の探索
- 2007 - 2009 Detection of cervical lymphnode micrometastasis in oral cancer
- 2007 - 2008 口腔白板症の悪性化に関わる因子は何か?-HuRと細胞質移行タンパクの解析-
- 2007 - 2008 Roles of p53 family proteins on the risk-factor of recurrence in oral squamous cell carcinomas.
- 2007 - 2008 Elucidation of the roles of an oncogene BCL6 in the adaptation response to hypoxia and its application to the therapy for esophageal cancer
- 2006 - 2007 顎骨骨折・顎骨欠損への再生医療の試み-ポリリン酸による顎骨誘導-
- 2006 - 2007 Analysis of Tumor-associated Endothelial Cell Biology
- 2006 - 2007 Development of gene delivery system using nanocoloid and its application for gene targeting therapy
- 2006 - 2007 Gene Targeting Therapy against tumor endothelial cells
- 2006 - 2007 Export and stabilization of AU-rich element containng mRNA in oral cancer cells
- 2005 - 2006 口腔がんの発症・進展におよぼす糖転移酵素GnT-Vの影響
- 2005 - 2006 転写因子相互作用による口腔がんの悪性形質獲得機構の解析
- 2005 - 2006 Evaluation of pre-operative Chemoradiotherapy in Oral Squamous Cell Carcinoma. -Integration of molecular biology and clinical state-
- 2005 - 2006 An exploitation of gene targeting therapy against hypoxic condition of oral carcinoma.
- 2005 - 2006 Roles of Pim-1 oncogene in oral squamous cell carcinoma.
- 2004 - 2005 Translation research for predicting the prognosis of oral malignant tumors.
- 2004 - 2005 Gene targeting therapy for oral carcinoma using adrenomedullin antagonisit.
- 2004 - 2005 Elucidation of the roles of Pim-1 induced under hypoxia in pancreatic cancer and its application to the cancer therapy
- 2003 - 2005 Molecular Targeted Therapy with Dominant Negative HIF-1 for Pancreatic Cancer
- 2004 - 2004 血管新生阻害因子アドレノメジュリンアンタゴニストによる膵癌の分子標的遺伝子治療
- 2003 - 2004 カーボンナノチューブによる細胞・組織へのデリバリーシステムの構築
- 2003 - 2004 Roles of Free Radicals Produced under Hypoxic Condition on the Tumor Development and Progression
- 2002 - 2003 FDG-PET検査の改良による腫瘍の鑑別診断法の開発:膜輸送遺伝子・酵素学的検討
- 2002 - 2003 Identification of HIF-1a target genes and their biological roles in oral carcinoma.
- 2002 - 2003 Research on factors involved in prognosis of oral carcinoma.
- 2002 - 2003 Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.
- 2002 - 2002 低酸素誘導転写因子(HIF-1)による低酸素適応応答を制御する薬剤の探索
- 2001 - 2002 Identification of mechanism of the metastasis via RhoC signal cascade and development of therapeutic gene for pancreatic cancer
- 2001 - 2002 Relationship of Drug Sensitivity and Expression of hypoxia-inducible factor-1 (HIF-1)
- 2001 - 2002 Induction of apoptosis in oral squamous cell carcinoma by activating caspase
- 2001 - 2002 Development of cancer specific vector for lung carcinoma by inducing RCAS1 ligand and SCCA promoter
- 2001 - 2001 低酸素誘導転写因子HIF-1αを標的分子とする膵癌治療法の開発
- 2001 - 2001 癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究
- 2000 - 2001 CD14とToll-Like Receptorを介したアポトーシス誘導機構の解析
- 2000 - 2001 Gene therapy for oral squamous cell carcinoma targeting tumor specific promoter activation
- 2000 - 2001 Development of gene therapy by using suppressor oncogene vHL for pancreatic cancer
- 2000 - 2001 The role of E1AF, an ets-oncogene family tranascription factor in cell cycle regulation.
- 1991 - 2001 Differentiation therapy
- 2000 - 2000 癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究
- 1999 - 2000 An atempt of gene therapy for oral squamous cell carcinoma
- 1999 - 1999 TGF-β産生抑制と宿主免疫増強を目的とした低用量癌化学療法の開発
- 1998 - 1999 Identification of targetgenes of E1AF using two hybrid system
- 1997 - 癌の低酸素適応応答
- 1997 - Adaptation respouse of cancer cell to hypoxia
- 1994 - 1995 Mechanisms for the formation of granulocytic sarcoma in leukemia
- 1994 - 1994 造血幹細胞の増殖・分化に与える接着因子の役割の検討
- 1993 - 1993 LAK細胞の癌組織集積性を増強するサイトカインの精製とその遺伝子の同定
- 1991 - 造血の制御機構
- 1991 - 癌の遺伝子治療
- 1991 - 癌化学療法と抗癌剤耐性
- 1991 - Regulation of hematopoiesis
- 1991 - Chemotherapy and drug resistance
- Gene therapy
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Papers (125)：
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Shin-Nosuke Yamashita, Yoshiatsu Tanaka, Takao Kitagawa, Byron Baron, Kazuhiro Tokuda, Durga Paudel, Koji Nakagawa, Tohru Ohta, Jun-Ichi Hamada, Masanobu Kobayashi, et al. Down-regulating Effect of a Standardized Extract of Cultured Lentinula edodes mycelia on Cortactin in Prostate Cancer Cells Is Dependent on Malignant Potential. Anticancer research. 2023. 43. 3. 1159-1166
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Takao Kitagawa, Shajedul Islam, Byron Baron, Kazuhiro Tokuda, Durga Paudel, Tohru Ohta, Koji Nakagawa, Masanobu Kobayashi, Futoshi Okada, Yasuhiro Kuramitsu. A Standardized Extract of Cultured Lentinula edodes mycelia Up-regulates COX-2 in Inflammation-related Malignant Progressive Fibrosarcoma Cell Clone QRsP-11. Anticancer research. 2023. 43. 3. 1239-1244
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Takao Kitagawa, Daiki Kobayashi, Byron Baron, Hajime Okita, Tatsuo Miyamoto, Rie Takai, Durga Paudel, Tohru Ohta, Yoichi Asaoka, Masayuki Tokunaga, et al. AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells. PLOS ONE. 2022. 17. 10. e0269077-e0269077
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Takao Kitagawa, Yasuhiro Kuramitsu, Kouji Nakagawa, Tohru Ohta, Kozo Akino, Masahiro Asaka, Masanobu Kobayashi. Antibody response to BNT162b2 mRNA vaccine in healthcare workers and residents in a long-term care facility. Geriatrics & gerontology international. 2022. 22. 2. 179-181
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Takao Kitagawa, Masanobu Kobayashi, Tohru Ohta, Masaru Terasaki, Yoko Tsukamoto, Rie Takai, Reika Ishizumi, Osamu Uehara, Koji Nakagawa, Kozo Akino, et al. Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2. IN VIVO. 2021. 35. 5. 2947-2949
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MISC (91)：
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久原啓資, 久原啓資, 北川孝雄, 小林正伸, 永易裕樹, 藏滿保宏. 被包化肝細胞癌組織のプロテオーム解析から狙う浸潤抑制. 電気泳動(Web). 2021. 65. Suppl
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Yusuke Kanda, Kunishige Onuma, Ayana Sonoda, Junichi Hamada, Masanobu Kobayashi, Mitsuhiko Osaki, Takahiro Ochiya, Futoshi Okada. Amigo2 determines liver metastasis through selective adhesion to liver endothelial cells. CANCER SCIENCE. 2018. 109. 1029-1029
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神田 裕介, 小沼 邦重, 園田 彩奈, 浜田 淳一, 小林 正伸, 尾崎 充彦, 落谷 孝広, 岡田 太. 肝転移を決定するAmigo2. 日本癌学会総会記事. 2017. 76回. P-3123
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神田裕介, 小沼邦重, 園田彩奈, 浜田淳一, 小林正伸, 尾崎充彦, 岡田太. 肝転移のドライバー分子としてのAmigo2の同定. 日本がん転移学会学術集会・総会プログラム抄録集. 2017. 26th. 71
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小沼 邦重, 神田 裕介, 野々村 拓也, 小林 正伸, 尾崎 充彦, 鹿内 正孝, 小林 博, 岡田 太. 発酵玄米による炎症発がんの抑制. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [3P-291]
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Books (3)：
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なるほどなっとく!病理学 : 病態形成の基本的なしくみ
南山堂 2015 ISBN:9784525151614
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やさしい腫瘍学
南江堂 2014
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がんと向き合う-道民のための基礎知識
2012
Education (2)：
- - 1953 Hokkaido University School of Medicine
- - 1953 Hokkaido University Faculty of Medicine Hokkaido University School of Medicine
Professional career (1)：
Association Membership(s) (3)：
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